Matches in SemOpenAlex for { <https://semopenalex.org/work/W2165775319> ?p ?o ?g. }
- W2165775319 endingPage "5414" @default.
- W2165775319 startingPage "5410" @default.
- W2165775319 abstract "The binding of chemokines to their receptors guides lymphocyte migration. However, the precise mechanism that links the chemotactic signals with the energy and traction force generated by the actomyosin complex of the cell has not been elucidated. Using biochemical approaches and mass spectrometry analysis, we found an association between the C-termini of CXCR4 and CCR5 and the motor protein nonmuscle myosin H chain-IIA. Immunoprecipitation experiments revealed that this association also occurs between the endogenous molecules in T lymphocytes. As expected, myosin L chain was also associated with CXCR4. Confocal microscopy analysis showed that CXCR4 and motor protein nonmuscle myosin H chain-IIA colocalize at the leading edge of migrating T lymphocytes, together with filamentous actin and myosin L chain. These results provide the first evidence of a biochemical association between chemokine receptors and motor proteins, a mechanosignaling mechanism that may have a key role in lymphocyte migration." @default.
- W2165775319 created "2016-06-24" @default.
- W2165775319 creator A5006841984 @default.
- W2165775319 creator A5035093031 @default.
- W2165775319 creator A5040725452 @default.
- W2165775319 creator A5059637698 @default.
- W2165775319 creator A5065643850 @default.
- W2165775319 creator A5074603864 @default.
- W2165775319 creator A5076241341 @default.
- W2165775319 creator A5081217694 @default.
- W2165775319 date "2002-11-15" @default.
- W2165775319 modified "2023-10-18" @default.
- W2165775319 title "Cutting Edge: Association of the Motor Protein Nonmuscle Myosin Heavy Chain-IIA with the C Terminus of the Chemokine Receptor CXCR4 in T Lymphocytes" @default.
- W2165775319 cites W1495926848 @default.
- W2165775319 cites W1507084693 @default.
- W2165775319 cites W1554826971 @default.
- W2165775319 cites W1588249072 @default.
- W2165775319 cites W1902051780 @default.
- W2165775319 cites W1964383505 @default.
- W2165775319 cites W1967720431 @default.
- W2165775319 cites W1981429363 @default.
- W2165775319 cites W1989076612 @default.
- W2165775319 cites W2001044562 @default.
- W2165775319 cites W2001434884 @default.
- W2165775319 cites W2005400238 @default.
- W2165775319 cites W2007210699 @default.
- W2165775319 cites W2008791808 @default.
- W2165775319 cites W2041247573 @default.
- W2165775319 cites W2042704418 @default.
- W2165775319 cites W2043488713 @default.
- W2165775319 cites W2047886675 @default.
- W2165775319 cites W2078337251 @default.
- W2165775319 cites W2078594804 @default.
- W2165775319 cites W2084576775 @default.
- W2165775319 cites W2102416981 @default.
- W2165775319 cites W2104721725 @default.
- W2165775319 cites W2108989813 @default.
- W2165775319 cites W2110808326 @default.
- W2165775319 cites W2119214706 @default.
- W2165775319 cites W2120087236 @default.
- W2165775319 cites W2124242970 @default.
- W2165775319 cites W2145393717 @default.
- W2165775319 cites W2160262946 @default.
- W2165775319 cites W2167885584 @default.
- W2165775319 cites W2172832962 @default.
- W2165775319 cites W2334904515 @default.
- W2165775319 cites W4313422313 @default.
- W2165775319 doi "https://doi.org/10.4049/jimmunol.169.10.5410" @default.
- W2165775319 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12421915" @default.
- W2165775319 hasPublicationYear "2002" @default.
- W2165775319 type Work @default.
- W2165775319 sameAs 2165775319 @default.
- W2165775319 citedByCount "56" @default.
- W2165775319 countsByYear W21657753192012 @default.
- W2165775319 countsByYear W21657753192013 @default.
- W2165775319 countsByYear W21657753192014 @default.
- W2165775319 countsByYear W21657753192015 @default.
- W2165775319 countsByYear W21657753192016 @default.
- W2165775319 countsByYear W21657753192017 @default.
- W2165775319 countsByYear W21657753192018 @default.
- W2165775319 countsByYear W21657753192019 @default.
- W2165775319 countsByYear W21657753192020 @default.
- W2165775319 countsByYear W21657753192022 @default.
- W2165775319 crossrefType "journal-article" @default.
- W2165775319 hasAuthorship W2165775319A5006841984 @default.
- W2165775319 hasAuthorship W2165775319A5035093031 @default.
- W2165775319 hasAuthorship W2165775319A5040725452 @default.
- W2165775319 hasAuthorship W2165775319A5059637698 @default.
- W2165775319 hasAuthorship W2165775319A5065643850 @default.
- W2165775319 hasAuthorship W2165775319A5074603864 @default.
- W2165775319 hasAuthorship W2165775319A5076241341 @default.
- W2165775319 hasAuthorship W2165775319A5081217694 @default.
- W2165775319 hasBestOaLocation W21657753191 @default.
- W2165775319 hasConcept C104317684 @default.
- W2165775319 hasConcept C125705527 @default.
- W2165775319 hasConcept C12823836 @default.
- W2165775319 hasConcept C13373296 @default.
- W2165775319 hasConcept C170493617 @default.
- W2165775319 hasConcept C185592680 @default.
- W2165775319 hasConcept C54166955 @default.
- W2165775319 hasConcept C55493867 @default.
- W2165775319 hasConcept C6997183 @default.
- W2165775319 hasConcept C71829478 @default.
- W2165775319 hasConcept C8035138 @default.
- W2165775319 hasConcept C86803240 @default.
- W2165775319 hasConcept C95444343 @default.
- W2165775319 hasConceptScore W2165775319C104317684 @default.
- W2165775319 hasConceptScore W2165775319C125705527 @default.
- W2165775319 hasConceptScore W2165775319C12823836 @default.
- W2165775319 hasConceptScore W2165775319C13373296 @default.
- W2165775319 hasConceptScore W2165775319C170493617 @default.
- W2165775319 hasConceptScore W2165775319C185592680 @default.
- W2165775319 hasConceptScore W2165775319C54166955 @default.
- W2165775319 hasConceptScore W2165775319C55493867 @default.
- W2165775319 hasConceptScore W2165775319C6997183 @default.
- W2165775319 hasConceptScore W2165775319C71829478 @default.
- W2165775319 hasConceptScore W2165775319C8035138 @default.
- W2165775319 hasConceptScore W2165775319C86803240 @default.