FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2165789214> ?p ?o ?g. }

• W2165789214 endingPage "38" @default.
• W2165789214 startingPage "1327" @default.
• W2165789214 abstract "Articular cartilage is an avascular connective tissue in which the availability of oxygen and glucose is significantly lower than synovial fluid and plasma. Glucose is an important metabolic fuel and structural precursor that plays a key role in the synthesis of extracellular matrix macromolecules in articular cartilage. However, glucose concentrations in cartilage can fluctuate depending on age, physical activity and endocrine status. Chondrocytes are glycolytic cells and must be able to sense the quantities of oxygen and glucose available to them in the extracellular matrix and respond appropriately by adjusting cellular metabolism. Consequently chondrocytes must have the capacity to survive in an extracellular matrix with limited nutrients and low oxygen tensions. The molecular mechanisms responsible for allowing chondrocytes to adapt to these harsh environmental conditions are poorly understood. In this article we present a novel dual model of oxygen and glucose sensing in chondrocytes based on recent experimental data. This model incorporates the hypoxia-inducible factor alpha (HIF-1alpha) as an oxygen sensor and the hypoxia responsive facilitative glucose transporters, GLUT1 and GLUT3 as putative components of the glucose sensing apparatus in chondrocytes. Recent studies have shown that GLUT1 and GLUT3 are both expressed in chondrocytes and their HIF-1alpha-mediated transcription may be dually stimulated in response to hypoxia and low glucose conditions which in turn promote anaerobic glycolysis in favor of oxidative phosphorylation. This working model provides, for the first time, a unifying hypothesis to explain how chondrocytes might sense and respond to low oxygen tensions and alterations in extracellular glucose." @default.
• W2165789214 created "2016-06-24" @default.
• W2165789214 creator A5013076020 @default.
• W2165789214 creator A5032252228 @default.
• W2165789214 creator A5038295064 @default.
• W2165789214 creator A5055606141 @default.
• W2165789214 creator A5074888361 @default.
• W2165789214 date "2005-10-01" @default.
• W2165789214 modified "2023-09-29" @default.
• W2165789214 title "Hypoxia inducible factor-1 and facilitative glucose transporters GLUT1 and GLUT3: putative molecular components of the oxygen and glucose sensing apparatus in articular chondrocytes." @default.
• W2165789214 cites W1495172026 @default.
• W2165789214 cites W1503667331 @default.
• W2165789214 cites W1885436530 @default.
• W2165789214 cites W1894212043 @default.
• W2165789214 cites W1911305856 @default.
• W2165789214 cites W1931051077 @default.
• W2165789214 cites W1961133493 @default.
• W2165789214 cites W1965608248 @default.
• W2165789214 cites W1965853505 @default.
• W2165789214 cites W1966676895 @default.
• W2165789214 cites W1976177239 @default.
• W2165789214 cites W1977389886 @default.
• W2165789214 cites W1983260994 @default.
• W2165789214 cites W1983838735 @default.
• W2165789214 cites W1985233399 @default.
• W2165789214 cites W1985657228 @default.
• W2165789214 cites W1993775249 @default.
• W2165789214 cites W1999601388 @default.
• W2165789214 cites W2004008188 @default.
• W2165789214 cites W2006525554 @default.
• W2165789214 cites W2007283880 @default.
• W2165789214 cites W2008246498 @default.
• W2165789214 cites W2010394923 @default.
• W2165789214 cites W2011587969 @default.
• W2165789214 cites W2014920745 @default.
• W2165789214 cites W2016220986 @default.
• W2165789214 cites W2017994898 @default.
• W2165789214 cites W2020594884 @default.
• W2165789214 cites W2022721465 @default.
• W2165789214 cites W2030319693 @default.
• W2165789214 cites W2030345672 @default.
• W2165789214 cites W2033847281 @default.
• W2165789214 cites W2035818549 @default.
• W2165789214 cites W2042469104 @default.
• W2165789214 cites W2042517754 @default.
• W2165789214 cites W2044929873 @default.
• W2165789214 cites W2047528517 @default.
• W2165789214 cites W2050442786 @default.
• W2165789214 cites W2050869563 @default.
• W2165789214 cites W2051802738 @default.
• W2165789214 cites W2054842789 @default.
• W2165789214 cites W2055852713 @default.
• W2165789214 cites W2061867428 @default.
• W2165789214 cites W2061994476 @default.
• W2165789214 cites W2066981289 @default.
• W2165789214 cites W2067389552 @default.
• W2165789214 cites W2071069499 @default.
• W2165789214 cites W2071318550 @default.
• W2165789214 cites W2071335476 @default.
• W2165789214 cites W2073292880 @default.
• W2165789214 cites W2074783201 @default.
• W2165789214 cites W2082646256 @default.
• W2165789214 cites W2090596605 @default.
• W2165789214 cites W2091137324 @default.
• W2165789214 cites W2093783940 @default.
• W2165789214 cites W2095262349 @default.
• W2165789214 cites W2098972920 @default.
• W2165789214 cites W2099397203 @default.
• W2165789214 cites W2100438537 @default.
• W2165789214 cites W2102526923 @default.
• W2165789214 cites W2105389636 @default.
• W2165789214 cites W2106091997 @default.
• W2165789214 cites W2107135340 @default.
• W2165789214 cites W2111158723 @default.
• W2165789214 cites W2118956583 @default.
• W2165789214 cites W2134012733 @default.
• W2165789214 cites W2135514341 @default.
• W2165789214 cites W2145938725 @default.
• W2165789214 cites W2170012278 @default.
• W2165789214 cites W2197722206 @default.
• W2165789214 cites W2278180536 @default.
• W2165789214 cites W2409302956 @default.
• W2165789214 cites W2436364901 @default.
• W2165789214 cites W2614284122 @default.
• W2165789214 doi "https://doi.org/10.14670/hh-20.1327" @default.
• W2165789214 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16136514" @default.
• W2165789214 hasPublicationYear "2005" @default.
• W2165789214 type Work @default.
• W2165789214 sameAs 2165789214 @default.
• W2165789214 citedByCount "54" @default.
• W2165789214 countsByYear W21657892142012 @default.
• W2165789214 countsByYear W21657892142013 @default.
• W2165789214 countsByYear W21657892142014 @default.
• W2165789214 countsByYear W21657892142015 @default.
• W2165789214 countsByYear W21657892142016 @default.
• W2165789214 countsByYear W21657892142017 @default.
• W2165789214 countsByYear W21657892142018 @default.
• W2165789214 countsByYear W21657892142019 @default.

• next