Matches in SemOpenAlex for { <https://semopenalex.org/work/W2165804446> ?p ?o ?g. }
- W2165804446 endingPage "1468" @default.
- W2165804446 startingPage "1453" @default.
- W2165804446 abstract "Aims: The hierarchy of evidence-based medicine determines the inferential powers of different clinical research designs. We want to address the difficult question if observational evidence under some circumstances can validate intervention effects. Methodology: Assessment of previous argumentation aiming at a clear conclusion for future decision-making. Results: We present five arguments demonstrating the fundamental need of randomized clinical trials to sufficiently validate intervention effects. Furthermore, we argue that hindrances to the conduct of randomized clinical trials can be lessened through education, collaboration, infrastructure, and other measures. Our arguments validate why the randomized clinical trial should and must be the study design evaluating interventions. By choosing the randomized clinical trial as the primary study design, effective preventive, prognostic, diagnostic, and therapeutic interventions will reach more patients earlier. Conclusion: Clinical experience or observational studies should never be used as the sole basis for assessment of intervention effects — randomized clinical trials are always needed. Therefore, always randomize the first patient as Thomas C Chalmers suggested in 1977. Observational studies should primarily be used for quality control after treatments are included in clinical practice. Policy Paper" @default.
- W2165804446 created "2016-06-24" @default.
- W2165804446 creator A5024824441 @default.
- W2165804446 creator A5039378997 @default.
- W2165804446 date "2013-01-10" @default.
- W2165804446 modified "2023-10-16" @default.
- W2165804446 title "The Necessity of Randomized Clinical Trials" @default.
- W2165804446 cites W1481853738 @default.
- W2165804446 cites W1491862272 @default.
- W2165804446 cites W1598602811 @default.
- W2165804446 cites W1641007866 @default.
- W2165804446 cites W1714980748 @default.
- W2165804446 cites W1926884931 @default.
- W2165804446 cites W1964502734 @default.
- W2165804446 cites W1969704932 @default.
- W2165804446 cites W1970637339 @default.
- W2165804446 cites W1973779355 @default.
- W2165804446 cites W1976576973 @default.
- W2165804446 cites W1981501248 @default.
- W2165804446 cites W1985075719 @default.
- W2165804446 cites W1988432737 @default.
- W2165804446 cites W1994327094 @default.
- W2165804446 cites W1997601216 @default.
- W2165804446 cites W1999326451 @default.
- W2165804446 cites W2001801035 @default.
- W2165804446 cites W2007116927 @default.
- W2165804446 cites W2013314123 @default.
- W2165804446 cites W2015824469 @default.
- W2165804446 cites W2017195038 @default.
- W2165804446 cites W2017587608 @default.
- W2165804446 cites W2029964950 @default.
- W2165804446 cites W2036458504 @default.
- W2165804446 cites W2043990618 @default.
- W2165804446 cites W2044103485 @default.
- W2165804446 cites W2045836903 @default.
- W2165804446 cites W2047544265 @default.
- W2165804446 cites W2049103906 @default.
- W2165804446 cites W2049432381 @default.
- W2165804446 cites W2051678503 @default.
- W2165804446 cites W2058081235 @default.
- W2165804446 cites W2065177605 @default.
- W2165804446 cites W2071477698 @default.
- W2165804446 cites W2072380646 @default.
- W2165804446 cites W2081814119 @default.
- W2165804446 cites W2082208744 @default.
- W2165804446 cites W2083637172 @default.
- W2165804446 cites W2084917404 @default.
- W2165804446 cites W2087460969 @default.
- W2165804446 cites W2089708520 @default.
- W2165804446 cites W2097964785 @default.
- W2165804446 cites W2102783876 @default.
- W2165804446 cites W2105125840 @default.
- W2165804446 cites W2106952837 @default.
- W2165804446 cites W2107021177 @default.
- W2165804446 cites W2107602010 @default.
- W2165804446 cites W2108628735 @default.
- W2165804446 cites W2109495812 @default.
- W2165804446 cites W2113552278 @default.
- W2165804446 cites W2114278251 @default.
- W2165804446 cites W2118344697 @default.
- W2165804446 cites W2120849219 @default.
- W2165804446 cites W2123253962 @default.
- W2165804446 cites W2123664031 @default.
- W2165804446 cites W2124110055 @default.
- W2165804446 cites W2129829737 @default.
- W2165804446 cites W2130566074 @default.
- W2165804446 cites W2137697845 @default.
- W2165804446 cites W2137813178 @default.
- W2165804446 cites W2139049236 @default.
- W2165804446 cites W2156294597 @default.
- W2165804446 cites W2160795579 @default.
- W2165804446 cites W2161566871 @default.
- W2165804446 cites W2165414412 @default.
- W2165804446 cites W2166165376 @default.
- W2165804446 cites W2167669404 @default.
- W2165804446 cites W2171152710 @default.
- W2165804446 cites W2185040217 @default.
- W2165804446 cites W2273931612 @default.
- W2165804446 cites W2315875464 @default.
- W2165804446 cites W2318633331 @default.
- W2165804446 cites W2408081177 @default.
- W2165804446 cites W2416901675 @default.
- W2165804446 cites W2421135617 @default.
- W2165804446 cites W2479717569 @default.
- W2165804446 cites W2497721881 @default.
- W2165804446 cites W2506210560 @default.
- W2165804446 cites W2598936606 @default.
- W2165804446 cites W2986772077 @default.
- W2165804446 cites W3122240419 @default.
- W2165804446 cites W590372522 @default.
- W2165804446 cites W634558559 @default.
- W2165804446 doi "https://doi.org/10.9734/bjmmr/2013/3208" @default.
- W2165804446 hasPublicationYear "2013" @default.
- W2165804446 type Work @default.
- W2165804446 sameAs 2165804446 @default.
- W2165804446 citedByCount "48" @default.
- W2165804446 countsByYear W21658044462013 @default.
- W2165804446 countsByYear W21658044462014 @default.