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• W2165821856 endingPage "1979" @default.
• W2165821856 startingPage "1973" @default.
• W2165821856 abstract "Colletotrichum dematium is an endophytic fungus recovered from a Pteromischum sp. growing in a tropical forest in Costa Rica. This fungus makes a novel peptide antimycotic, colutellin A, with a MIC of 3.6 μg ml−1 (48 h) against Botrytis cinerea and Sclerotinia sclerotiorum. Collutellin A has a mass of 1127.7 Da and contains residues of Ile, Val, Ser, N-methyl-Val and β-aminoisobutryic acid in nominal molar ratios of 3 : 2 : 1 : 1 : 1, respectively. Independent lines of evidence suggest that the peptide is cyclic and sequences of Val-Ile-Ser-Ile and Ile-Pro-Val have been deduced by MS/MS as well as Edman degradation methods. Colutellin A inhibited CD4+ T-cell activation of interleukin 2 (IL-2) production with an IC50 of 167.3±0.38 nM, whereas cyclosporin A in the same test yielded a value of 61.8 nM. Inhibition of IL-2 production by collutellin A at such a low concentration indicates the potential immunosuppressive activity of this compound. In repeated experiments, cyclosporin A at or above 8 μg ml−1 exhibited high levels of cytotoxicity on human peripheral blood mononuclear cells, whereas collutellin A or DMSO (carrier) alone, after 24 and 48 h of culture, exhibited no toxicity. Because of these properties collutellin A has potential as a novel immunosuppressive drug." @default.
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• W2165821856 date "2008-07-01" @default.
• W2165821856 modified "2023-09-23" @default.
• W2165821856 title "Colutellin A, an immunosuppressive peptide from Colletotrichum dematium" @default.
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• W2165821856 doi "https://doi.org/10.1099/mic.0.2008/017954-0" @default.
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