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• W2165837112 startingPage "e5494" @default.
• W2165837112 abstract "The hippocampus is essential for the formation of memories for events, but the specific features of hippocampal neural activity that support memory formation are not yet understood. The ideal experiment to explore this issue would be to monitor changes in hippocampal neural coding throughout the entire learning process, as subjects acquire and use new episodic memories to guide behavior. Unfortunately, it is not clear whether established hippocampally-dependent learning paradigms are suitable for this kind of experiment. The goal of this study was to determine whether learning of the W-track continuous alternation task depends on the hippocampal formation. We tested six rats with NMDA lesions of the hippocampal formation and four sham-operated controls. Compared to controls, rats with hippocampal lesions made a significantly higher proportion of errors and took significantly longer to reach learning criterion. The effect of hippocampal lesion was not due to a deficit in locomotion or motivation, because rats with hippocampal lesions ran well on a linear track for food reward. Rats with hippocampal lesions also exhibited a pattern of perseverative errors during early task experience suggestive of an inability to suppress behaviors learned during pretraining on a linear track. Our findings establish the W-track continuous alternation task as a hippocampally-dependent learning paradigm which may be useful for identifying changes in the neural representation of spatial sequences and reward contingencies as rats learn and apply new task rules." @default.
• W2165837112 created "2016-06-24" @default.
• W2165837112 creator A5017706351 @default.
• W2165837112 creator A5060193294 @default.
• W2165837112 date "2009-05-08" @default.
• W2165837112 modified "2023-10-13" @default.
• W2165837112 title "Hippocampal Lesions Impair Rapid Learning of a Continuous Spatial Alternation Task" @default.
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• W2165837112 doi "https://doi.org/10.1371/journal.pone.0005494" @default.
• W2165837112 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2674562" @default.
• W2165837112 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19424438" @default.
• W2165837112 hasPublicationYear "2009" @default.
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