Matches in SemOpenAlex for { <https://semopenalex.org/work/W2165859480> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2165859480 endingPage "2374" @default.
- W2165859480 startingPage "2366" @default.
- W2165859480 abstract "For decades coronary macrovascular atherosclerosis has been considered the principal manifestation of coronary heart disease, with most of our effort dedicated to identifying and removal of coronary stenosis. However, growing body of literature indicates that coronary microcirculation also contributes substantially to the pathophysiology of cardiovascular disease. An understanding of mechanisms regulating microvascular function is of critical importance in understanding its role in disease, especially because these regulatory mechanisms vary substantially across species, vascular bed and due to comorbidities. Indeed, the most obvious consequence of coronary stenosis is that it may limit blood supply to the dependent myocardium to the point of causing ischaemia during exercise or even at rest. However, this flow limiting effect is not only due to the passive hydraulic effect of a narrowed conduit, but also to active responses in the coronary microcirculation triggered by the presence of an epicardial stenosis. To understand this problem it is important to review the inter-related mechanisms that regulate flow to the left ventricular wall and modulate transmural distribution of flow. These regulatory mechanisms operate hierarchically and are heterogeneously distributed along the coronary vascular tree. It is also important to discuss the effect of myocardial performance in modulating both blood flow demands and coronary resistance. Some of the interactions between coronary stenosis and microcirculation are transient, like those documented in acute coronary syndromes or during percutaneous interventions. However, microcirculatory remodeling may be triggered by a chronic coronary stenosis, leading to a sustained impairment of blood supply even after successful removal of the epicardial stenosis. A deeper understanding of these phenomena may explain paradoxical findings in patients undergoing coronary revascularization, particularly when functional tests are used in their assessment. These aspects are discussed in detail in this review. Keywords: Coronary microcirculation, coronary stenosis, myocardial ischemia, endothelial dysfunction, atherosclerosis, cardiovascular disease, blood supply, myocardium, transient, coronary revascularization" @default.
- W2165859480 created "2016-06-24" @default.
- W2165859480 creator A5008223259 @default.
- W2165859480 creator A5025715284 @default.
- W2165859480 creator A5031925470 @default.
- W2165859480 creator A5040842093 @default.
- W2165859480 creator A5041699743 @default.
- W2165859480 creator A5052210888 @default.
- W2165859480 date "2013-03-01" @default.
- W2165859480 modified "2023-10-16" @default.
- W2165859480 title "Microvascular Function/Dysfunction Downstream a Coronary Stenosis" @default.
- W2165859480 doi "https://doi.org/10.2174/1381612811319130004" @default.
- W2165859480 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23173585" @default.
- W2165859480 hasPublicationYear "2013" @default.
- W2165859480 type Work @default.
- W2165859480 sameAs 2165859480 @default.
- W2165859480 citedByCount "13" @default.
- W2165859480 countsByYear W21658594802014 @default.
- W2165859480 countsByYear W21658594802015 @default.
- W2165859480 countsByYear W21658594802018 @default.
- W2165859480 countsByYear W21658594802019 @default.
- W2165859480 countsByYear W21658594802020 @default.
- W2165859480 countsByYear W21658594802021 @default.
- W2165859480 countsByYear W21658594802022 @default.
- W2165859480 crossrefType "journal-article" @default.
- W2165859480 hasAuthorship W2165859480A5008223259 @default.
- W2165859480 hasAuthorship W2165859480A5025715284 @default.
- W2165859480 hasAuthorship W2165859480A5031925470 @default.
- W2165859480 hasAuthorship W2165859480A5040842093 @default.
- W2165859480 hasAuthorship W2165859480A5041699743 @default.
- W2165859480 hasAuthorship W2165859480A5052210888 @default.
- W2165859480 hasConcept C126322002 @default.
- W2165859480 hasConcept C12722491 @default.
- W2165859480 hasConcept C158846371 @default.
- W2165859480 hasConcept C164705383 @default.
- W2165859480 hasConcept C2776157398 @default.
- W2165859480 hasConcept C2776820930 @default.
- W2165859480 hasConcept C2778213512 @default.
- W2165859480 hasConcept C2778707443 @default.
- W2165859480 hasConcept C2778742706 @default.
- W2165859480 hasConcept C2780007028 @default.
- W2165859480 hasConcept C2994477613 @default.
- W2165859480 hasConcept C71924100 @default.
- W2165859480 hasConceptScore W2165859480C126322002 @default.
- W2165859480 hasConceptScore W2165859480C12722491 @default.
- W2165859480 hasConceptScore W2165859480C158846371 @default.
- W2165859480 hasConceptScore W2165859480C164705383 @default.
- W2165859480 hasConceptScore W2165859480C2776157398 @default.
- W2165859480 hasConceptScore W2165859480C2776820930 @default.
- W2165859480 hasConceptScore W2165859480C2778213512 @default.
- W2165859480 hasConceptScore W2165859480C2778707443 @default.
- W2165859480 hasConceptScore W2165859480C2778742706 @default.
- W2165859480 hasConceptScore W2165859480C2780007028 @default.
- W2165859480 hasConceptScore W2165859480C2994477613 @default.
- W2165859480 hasConceptScore W2165859480C71924100 @default.
- W2165859480 hasIssue "13" @default.
- W2165859480 hasLocation W21658594801 @default.
- W2165859480 hasLocation W21658594802 @default.
- W2165859480 hasOpenAccess W2165859480 @default.
- W2165859480 hasPrimaryLocation W21658594801 @default.
- W2165859480 hasRelatedWork W1595144155 @default.
- W2165859480 hasRelatedWork W1983113346 @default.
- W2165859480 hasRelatedWork W1986318255 @default.
- W2165859480 hasRelatedWork W2029135373 @default.
- W2165859480 hasRelatedWork W2104079895 @default.
- W2165859480 hasRelatedWork W2397775925 @default.
- W2165859480 hasRelatedWork W2415941590 @default.
- W2165859480 hasRelatedWork W2965806166 @default.
- W2165859480 hasRelatedWork W2999161988 @default.
- W2165859480 hasRelatedWork W3170626207 @default.
- W2165859480 hasVolume "19" @default.
- W2165859480 isParatext "false" @default.
- W2165859480 isRetracted "false" @default.
- W2165859480 magId "2165859480" @default.
- W2165859480 workType "article" @default.