FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2165894130> ?p ?o ?g. }

• W2165894130 endingPage "H689" @default.
• W2165894130 startingPage "H680" @default.
• W2165894130 abstract "Insulin resistance (IR) is a condition where different organs are refractory to insulin stimulation of glucose uptake. ANG II has been suggested to be involved in the development of IR in the heart. The precise mechanism by which this occurs is still unknown. Here we have used dynamic fluorescent imaging techniques to show that ANG II inhibits insulin production of phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P(3)] in cardiac myocytes. Fluorophore (Venus)-conjugated cAMP-dependent protein kinase-pleckstrin homology domain, which specifically binds to PI(3,4,5)P(3), was transfected in neonatal rat cardiac myocytes. Insulin induced a robust increase in the fluorescence intensity at the cell surface, which was diminished by application of ANG II. The inhibitory action of ANG II was antagonized by RNH-6270 (an angiotensin type 1 receptor antagonist) but not by PD-122370 (an angiotensin type 2 receptor antagonist). BAPTA-AM (Ca(2+) chelator) largely attenuated the ANG II effect, whereas K-252b (PKC inhibitor) did not. Furthermore, an elevation of intracellular Ca(2+) induced by ionomycin mimicked the ANG II effect. Therefore, it is suggested that ANG II antagonizes insulin-mediated production of PI(3,4,5)P(3) via a Ca(2+)-dependent but PKC-independent pathway in cardiac myocytes." @default.
• W2165894130 created "2016-06-24" @default.
• W2165894130 creator A5021267745 @default.
• W2165894130 creator A5030582304 @default.
• W2165894130 creator A5058118162 @default.
• W2165894130 creator A5078822609 @default.
• W2165894130 creator A5080124007 @default.
• W2165894130 creator A5082949432 @default.
• W2165894130 creator A5084693611 @default.
• W2165894130 date "2010-09-01" @default.
• W2165894130 modified "2023-10-17" @default.
• W2165894130 title "ANG II inhibits insulin-mediated production of PI 3,4,5-trisphosphates via a Ca2+-dependent but PKC-independent pathway in the cardiomyocytes" @default.
• W2165894130 cites W1831397134 @default.
• W2165894130 cites W1965711636 @default.
• W2165894130 cites W1972190403 @default.
• W2165894130 cites W1972866300 @default.
• W2165894130 cites W1973837499 @default.
• W2165894130 cites W1974530349 @default.
• W2165894130 cites W1975864662 @default.
• W2165894130 cites W1984476260 @default.
• W2165894130 cites W1987613834 @default.
• W2165894130 cites W1991296399 @default.
• W2165894130 cites W1995357234 @default.
• W2165894130 cites W2002142406 @default.
• W2165894130 cites W2004740433 @default.
• W2165894130 cites W2024214080 @default.
• W2165894130 cites W2026973601 @default.
• W2165894130 cites W2030338284 @default.
• W2165894130 cites W2039210066 @default.
• W2165894130 cites W2044868069 @default.
• W2165894130 cites W2055109959 @default.
• W2165894130 cites W2058755393 @default.
• W2165894130 cites W2063975035 @default.
• W2165894130 cites W2069929383 @default.
• W2165894130 cites W2078748771 @default.
• W2165894130 cites W2081351747 @default.
• W2165894130 cites W2085812290 @default.
• W2165894130 cites W2086475005 @default.
• W2165894130 cites W2090644026 @default.
• W2165894130 cites W2107446346 @default.
• W2165894130 cites W2118048953 @default.
• W2165894130 cites W2123640306 @default.
• W2165894130 cites W2128842224 @default.
• W2165894130 cites W2143677012 @default.
• W2165894130 cites W2151477904 @default.
• W2165894130 cites W2152334831 @default.
• W2165894130 cites W2152931086 @default.
• W2165894130 cites W2165604272 @default.
• W2165894130 cites W2166763377 @default.
• W2165894130 cites W4254464763 @default.
• W2165894130 doi "https://doi.org/10.1152/ajpheart.00220.2009" @default.
• W2165894130 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20601457" @default.
• W2165894130 hasPublicationYear "2010" @default.
• W2165894130 type Work @default.
• W2165894130 sameAs 2165894130 @default.
• W2165894130 citedByCount "4" @default.
• W2165894130 countsByYear W21658941302012 @default.
• W2165894130 countsByYear W21658941302013 @default.
• W2165894130 crossrefType "journal-article" @default.
• W2165894130 hasAuthorship W2165894130A5021267745 @default.
• W2165894130 hasAuthorship W2165894130A5030582304 @default.
• W2165894130 hasAuthorship W2165894130A5058118162 @default.
• W2165894130 hasAuthorship W2165894130A5078822609 @default.
• W2165894130 hasAuthorship W2165894130A5080124007 @default.
• W2165894130 hasAuthorship W2165894130A5082949432 @default.
• W2165894130 hasAuthorship W2165894130A5084693611 @default.
• W2165894130 hasConcept C126322002 @default.
• W2165894130 hasConcept C134018914 @default.
• W2165894130 hasConcept C170493617 @default.
• W2165894130 hasConcept C185592680 @default.
• W2165894130 hasConcept C195794163 @default.
• W2165894130 hasConcept C207200792 @default.
• W2165894130 hasConcept C24998067 @default.
• W2165894130 hasConcept C2776989580 @default.
• W2165894130 hasConcept C2779306644 @default.
• W2165894130 hasConcept C2780019300 @default.
• W2165894130 hasConcept C2908929049 @default.
• W2165894130 hasConcept C62478195 @default.
• W2165894130 hasConcept C71924100 @default.
• W2165894130 hasConcept C86803240 @default.
• W2165894130 hasConcept C95444343 @default.
• W2165894130 hasConceptScore W2165894130C126322002 @default.
• W2165894130 hasConceptScore W2165894130C134018914 @default.
• W2165894130 hasConceptScore W2165894130C170493617 @default.
• W2165894130 hasConceptScore W2165894130C185592680 @default.
• W2165894130 hasConceptScore W2165894130C195794163 @default.
• W2165894130 hasConceptScore W2165894130C207200792 @default.
• W2165894130 hasConceptScore W2165894130C24998067 @default.
• W2165894130 hasConceptScore W2165894130C2776989580 @default.
• W2165894130 hasConceptScore W2165894130C2779306644 @default.
• W2165894130 hasConceptScore W2165894130C2780019300 @default.
• W2165894130 hasConceptScore W2165894130C2908929049 @default.
• W2165894130 hasConceptScore W2165894130C62478195 @default.
• W2165894130 hasConceptScore W2165894130C71924100 @default.
• W2165894130 hasConceptScore W2165894130C86803240 @default.
• W2165894130 hasConceptScore W2165894130C95444343 @default.
• W2165894130 hasIssue "3" @default.
• W2165894130 hasLocation W21658941301 @default.

• next