Matches in SemOpenAlex for { <https://semopenalex.org/work/W2165924919> ?p ?o ?g. }
- W2165924919 endingPage "14" @default.
- W2165924919 startingPage "2705" @default.
- W2165924919 abstract "More than two-thirds of patients diagnosed with esophageal cancer will have unresectable disease. The objective of this article is to review the clinical trials utilizing cytotoxic chemotherapy in patients with recurrent and metastatic esophageal cancer. A computerized (MEDLINE) search was performed to identify papers published on this topic between 1966 and 2007. A total of 96 trials were subsequently identified. Two randomized trials compared palliative chemotherapy with best supportive care in 180 patients with advanced esophageal cancer. Effectiveness and side-effects were evaluated in 49 phase II studies and 3 randomized phase III trials. Combination chemotherapy as compared to monochemotherapy is associated with significantly higher response rates but nevertheless results in similar survival. CF (cisplatin and 5-fluorouracil) currently represents one of the most effective regimens for advanced esophageal cancer, while among the newer combinations, irinotecan or taxane-based regimens have also given promising results. Prognosis for the majority of patients, however, remains poor as increases in survival were moderate at best." @default.
- W2165924919 created "2016-06-24" @default.
- W2165924919 creator A5047025255 @default.
- W2165924919 creator A5071984747 @default.
- W2165924919 creator A5076684030 @default.
- W2165924919 creator A5091065205 @default.
- W2165924919 date "2007-08-19" @default.
- W2165924919 modified "2023-10-05" @default.
- W2165924919 title "Palliative chemotherapy for recurrent and metastatic esophageal cancer." @default.
- W2165924919 cites W1437566490 @default.
- W2165924919 cites W1565414915 @default.
- W2165924919 cites W1567205022 @default.
- W2165924919 cites W1843791750 @default.
- W2165924919 cites W1845207649 @default.
- W2165924919 cites W1878554291 @default.
- W2165924919 cites W1904805820 @default.
- W2165924919 cites W1920900131 @default.
- W2165924919 cites W193233021 @default.
- W2165924919 cites W1947407197 @default.
- W2165924919 cites W1970194999 @default.
- W2165924919 cites W1972368916 @default.
- W2165924919 cites W1976791784 @default.
- W2165924919 cites W1980891192 @default.
- W2165924919 cites W1987586109 @default.
- W2165924919 cites W1992103975 @default.
- W2165924919 cites W1996197523 @default.
- W2165924919 cites W1996994296 @default.
- W2165924919 cites W2003954506 @default.
- W2165924919 cites W2004348451 @default.
- W2165924919 cites W2007085333 @default.
- W2165924919 cites W2009057064 @default.
- W2165924919 cites W2012740157 @default.
- W2165924919 cites W2013454488 @default.
- W2165924919 cites W2021728910 @default.
- W2165924919 cites W2027298808 @default.
- W2165924919 cites W2031958221 @default.
- W2165924919 cites W2032792368 @default.
- W2165924919 cites W2034947658 @default.
- W2165924919 cites W2037271587 @default.
- W2165924919 cites W2041959320 @default.
- W2165924919 cites W2044035331 @default.
- W2165924919 cites W2045657776 @default.
- W2165924919 cites W2047862714 @default.
- W2165924919 cites W2048667344 @default.
- W2165924919 cites W2051894533 @default.
- W2165924919 cites W2052715399 @default.
- W2165924919 cites W2055299261 @default.
- W2165924919 cites W2058272907 @default.
- W2165924919 cites W2061112867 @default.
- W2165924919 cites W2064316894 @default.
- W2165924919 cites W2065819686 @default.
- W2165924919 cites W2080673255 @default.
- W2165924919 cites W2084929520 @default.
- W2165924919 cites W2085220008 @default.
- W2165924919 cites W2085762166 @default.
- W2165924919 cites W2088505771 @default.
- W2165924919 cites W2088927932 @default.
- W2165924919 cites W2092696651 @default.
- W2165924919 cites W2092878111 @default.
- W2165924919 cites W2093634788 @default.
- W2165924919 cites W2096193119 @default.
- W2165924919 cites W2106787323 @default.
- W2165924919 cites W2107595609 @default.
- W2165924919 cites W2111476309 @default.
- W2165924919 cites W2112637679 @default.
- W2165924919 cites W2114597296 @default.
- W2165924919 cites W2116435502 @default.
- W2165924919 cites W2116869832 @default.
- W2165924919 cites W2125406417 @default.
- W2165924919 cites W2138098788 @default.
- W2165924919 cites W2143863553 @default.
- W2165924919 cites W2145555831 @default.
- W2165924919 cites W2145615263 @default.
- W2165924919 cites W2148615569 @default.
- W2165924919 cites W2157215374 @default.
- W2165924919 cites W2169690094 @default.
- W2165924919 cites W2223406810 @default.
- W2165924919 cites W2276503181 @default.
- W2165924919 cites W2339476630 @default.
- W2165924919 cites W2347045438 @default.
- W2165924919 cites W2397957042 @default.
- W2165924919 cites W2400141859 @default.
- W2165924919 cites W2401044998 @default.
- W2165924919 cites W2401338037 @default.
- W2165924919 cites W2404398264 @default.
- W2165924919 cites W2409352273 @default.
- W2165924919 cites W2409393169 @default.
- W2165924919 cites W2412769577 @default.
- W2165924919 cites W2412971678 @default.
- W2165924919 cites W2414310891 @default.
- W2165924919 cites W2414711194 @default.
- W2165924919 cites W2416878633 @default.
- W2165924919 cites W2416892607 @default.
- W2165924919 cites W2417774287 @default.
- W2165924919 cites W2418857877 @default.
- W2165924919 cites W2436972651 @default.
- W2165924919 cites W2439940521 @default.
- W2165924919 cites W2442482721 @default.