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• W2165980629 endingPage "155" @default.
• W2165980629 startingPage "143" @default.
• W2165980629 abstract "Purpose. To provide a comprehensive literature review of chemotherapy-induced nail toxicity, including clinical presentation, implicated drugs and approaches for prevention and management. Data sources. A search of MEDLINE and EMBASE (1966—2008) databases was conducted using the terms (and variations of the terms) antineoplastic agents, nails, nail toxicity, onycholysis, and paronychia. Bibliographies from selected articles were reviewed for appropriate references. Data extraction. The retrieved literature was reviewed to include all articles relevant to the clinical presentation, diagnosis, incidence, prevention, and treatment of chemotherapy-induced nail toxicity. Data synthesis. Nail toxicity is a relatively uncommon adverse effect linked to a number of chemotherapeutic agents. Clinical presentation varies, depending on which nail structure is affected and the severity of the insult. Nail changes may involve all or some nails. Toxicity may be asymptomatic and limited to cosmetic concerns, however, more severe effects, involving pain and discomfort can occur. Taxanes and anthracyclines are the antineoplastic drug groups most commonly implicated. It is suggested that the administration schedule may influence the incidence of nail abnormalities, for example reported cases linked to the weekly administration of paclitaxel. Before instituting chemotherapy, patients should be educated regarding potential nail toxicities and strategies for prevention implemented. Management includes appropriate nail cutting, avoiding potential irritants, topical, or oral antimicrobials, and possibly cessation or dose reduction of the offending agent. Cryotherapy, through the application of frozen gloves or socks, has been beneficial in reducing docetaxel-induced nail toxicity and may be effective for other drugs. J Oncol Pharm Practice (2009) 15: 143—155." @default.
• W2165980629 created "2016-06-24" @default.
• W2165980629 creator A5002136480 @default.
• W2165980629 creator A5022120416 @default.
• W2165980629 creator A5036157440 @default.
• W2165980629 date "2009-01-26" @default.
• W2165980629 modified "2023-10-03" @default.
• W2165980629 title "Nail Toxicity Induced by Cancer Chemotherapy" @default.
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• W2165980629 doi "https://doi.org/10.1177/1078155208100450" @default.
• W2165980629 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19171552" @default.
• W2165980629 hasPublicationYear "2009" @default.
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• W2165980629 citedByCount "78" @default.

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