FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2165984704> ?p ?o ?g. }

• W2165984704 endingPage "3844" @default.
• W2165984704 startingPage "3834" @default.
• W2165984704 abstract "The periodontal pathogen Porphyromonas gingivalis employs a variety of mechanisms for the uptake of hemin and inorganic iron. Previous work demonstrated that hemin uptake in P. gingivalis may be controlled by LuxS-mediated signaling. In the present study, the expression of genes involved in hemin and iron uptake was determined in parent and luxS mutant strains by quantitative real-time reverse transcription-PCR. Compared to the parental strain, the luxS mutant showed reduced levels of transcription of genes coding for the TonB-linked hemin binding protein Tlr and the lysine-specific protease Kgp, which can degrade host heme-containing proteins. In contrast, there was up-regulation of the genes for another TonB-linked hemin binding protein, HmuR; a hemin binding lipoprotein, FetB; a Fe(2+) ion transport protein, FeoB1; and the iron storage protein ferritin. Differential expression of these genes in the luxS mutant was maximal in early-exponential phase, which corresponded with peak expression of luxS and AI-2 signal activity. Complementation of the luxS mutation with wild-type luxS in trans rescued expression of hmuR. Mutation of the GppX two-component signal transduction pathway caused an increase in expression of luxS along with tlr and lower levels of message for hmuR. Moreover, expression of hmuR was repressed, and expression of tlr stimulated, when the luxS mutant was incubated with AI-2 partially purified from the culture supernatant of wild-type cells. A phenotypic outcome of the altered expression of genes involved in hemin uptake was impairment of growth of the luxS mutant in hemin-depleted medium. The results demonstrate a role of LuxS/AI-2 in the regulation of hemin and iron acquisition pathways in P. gingivalis and reveal a novel control pathway for luxS expression." @default.
• W2165984704 created "2016-06-24" @default.
• W2165984704 creator A5000400855 @default.
• W2165984704 creator A5004137542 @default.
• W2165984704 creator A5008946134 @default.
• W2165984704 creator A5016818092 @default.
• W2165984704 creator A5040300978 @default.
• W2165984704 creator A5040308100 @default.
• W2165984704 creator A5056376391 @default.
• W2165984704 creator A5085761568 @default.
• W2165984704 date "2006-07-01" @default.
• W2165984704 modified "2023-10-16" @default.
• W2165984704 title "LuxS Involvement in the Regulation of Genes Coding for Hemin and Iron Acquisition Systems in <i>Porphyromonas gingivalis</i>" @default.
• W2165984704 cites W1495496122 @default.
• W2165984704 cites W1505015935 @default.
• W2165984704 cites W1578940970 @default.
• W2165984704 cites W1606248785 @default.
• W2165984704 cites W1820124571 @default.
• W2165984704 cites W1927570869 @default.
• W2165984704 cites W1934248043 @default.
• W2165984704 cites W1943112463 @default.
• W2165984704 cites W1959548112 @default.
• W2165984704 cites W1965865579 @default.
• W2165984704 cites W1970499058 @default.
• W2165984704 cites W1972435034 @default.
• W2165984704 cites W1974427319 @default.
• W2165984704 cites W1976737261 @default.
• W2165984704 cites W1981925648 @default.
• W2165984704 cites W1993616876 @default.
• W2165984704 cites W1996872292 @default.
• W2165984704 cites W2004056501 @default.
• W2165984704 cites W2006606882 @default.
• W2165984704 cites W2009245874 @default.
• W2165984704 cites W2010866564 @default.
• W2165984704 cites W2013719025 @default.
• W2165984704 cites W2027484984 @default.
• W2165984704 cites W2028578959 @default.
• W2165984704 cites W2039582130 @default.
• W2165984704 cites W2040641257 @default.
• W2165984704 cites W2047457818 @default.
• W2165984704 cites W2049851061 @default.
• W2165984704 cites W2051841735 @default.
• W2165984704 cites W2052255348 @default.
• W2165984704 cites W2052851334 @default.
• W2165984704 cites W2056932987 @default.
• W2165984704 cites W2071784720 @default.
• W2165984704 cites W2079698171 @default.
• W2165984704 cites W2082410833 @default.
• W2165984704 cites W2085702368 @default.
• W2165984704 cites W2091337262 @default.
• W2165984704 cites W2094000042 @default.
• W2165984704 cites W2098064749 @default.
• W2165984704 cites W2098626852 @default.
• W2165984704 cites W2101222303 @default.
• W2165984704 cites W2101673942 @default.
• W2165984704 cites W2103359264 @default.
• W2165984704 cites W2108808336 @default.
• W2165984704 cites W2109277022 @default.
• W2165984704 cites W2112063053 @default.
• W2165984704 cites W2114554221 @default.
• W2165984704 cites W2115130110 @default.
• W2165984704 cites W2115808190 @default.
• W2165984704 cites W2116024991 @default.
• W2165984704 cites W2119158447 @default.
• W2165984704 cites W2120960183 @default.
• W2165984704 cites W2121992777 @default.
• W2165984704 cites W2123937142 @default.
• W2165984704 cites W2126470914 @default.
• W2165984704 cites W2132417094 @default.
• W2165984704 cites W2133664523 @default.
• W2165984704 cites W2134555745 @default.
• W2165984704 cites W2135965452 @default.
• W2165984704 cites W2138452485 @default.
• W2165984704 cites W2138776000 @default.
• W2165984704 cites W2142722173 @default.
• W2165984704 cites W2143609157 @default.
• W2165984704 cites W2144640625 @default.
• W2165984704 cites W2145166342 @default.
• W2165984704 cites W2147126668 @default.
• W2165984704 cites W2150890529 @default.
• W2165984704 cites W2151001863 @default.
• W2165984704 cites W2151026811 @default.
• W2165984704 cites W2151687098 @default.
• W2165984704 cites W2153592812 @default.
• W2165984704 cites W2154819662 @default.
• W2165984704 cites W2157092031 @default.
• W2165984704 cites W2158326203 @default.
• W2165984704 cites W2158792388 @default.
• W2165984704 cites W2162311254 @default.
• W2165984704 cites W2162654722 @default.
• W2165984704 cites W2162863229 @default.
• W2165984704 cites W2164230754 @default.
• W2165984704 cites W2167637231 @default.
• W2165984704 cites W2169785398 @default.
• W2165984704 cites W2171939089 @default.
• W2165984704 cites W2172170936 @default.
• W2165984704 cites W4229579701 @default.
• W2165984704 doi "https://doi.org/10.1128/iai.01768-05" @default.

• next