FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2165986712> ?p ?o ?g. }

• W2165986712 endingPage "636" @default.
• W2165986712 startingPage "625" @default.
• W2165986712 abstract "ABSTRACT “ Mycobacterium avium subsp. hominissuis ” is an opportunistic environmental pathogen that causes respiratory illness in immunocompromised patients, such as those with cystic fibrosis as well as other chronic respiratory diseases. Currently, there is no efficient approach to prevent or treat M. avium subsp. hominissuis infection in the lungs. During initial colonization of the airways, M. avium subsp. hominissuis forms microaggregates composed of 3 to 20 bacteria on human respiratory epithelial cells, which provides an environment for phenotypic changes leading to efficient mucosal invasion in vitro and in vivo . DNA microarray analysis was employed to identify genes associated with the microaggregate phenotype. The gene encoding microaggregate-binding protein 1 (MBP-1) (MAV_3013) is highly expressed during microaggregate formation. When expressed in noninvasive Mycobacterium smegmatis , MBP-1 increased the ability of the bacteria to bind to HEp-2 epithelial cells. Using anti-MBP-1 immune serum, microaggregate binding to HEp-2 cells was significantly reduced. By far-Western blotting, and verified by coimmunoprecipitation, we observed that MBP-1 interacts with the host cytoskeletal protein vimentin. As visualized by confocal microscopy, microaggregates, as well as MBP-1, induced vimentin polymerization at the site of bacterium-host cell contact. Binding of microaggregates to HEp-2 cells was inhibited by treatment with an antivimentin antibody, suggesting that MBP-1 expression is important for M. avium subsp. hominissuis adherence to the host cell. MBP-1 immune serum significantly inhibited M. avium subsp. hominissuis infection throughout the respiratory tracts of mice. This study characterizes a pathogenic mechanism utilized by M. avium subsp. hominissuis to bind and invade the host respiratory epithelium, suggesting new potential targets for the development of antivirulence therapy." @default.
• W2165986712 created "2016-06-24" @default.
• W2165986712 creator A5044536494 @default.
• W2165986712 creator A5067922669 @default.
• W2165986712 creator A5079637172 @default.
• W2165986712 creator A5079951129 @default.
• W2165986712 date "2015-02-01" @default.
• W2165986712 modified "2023-10-01" @default.
• W2165986712 title "The Environment of “Mycobacterium avium subsp. hominissuis” Microaggregates Induces Synthesis of Small Proteins Associated with Efficient Infection of Respiratory Epithelial Cells" @default.
• W2165986712 cites W155617828 @default.
• W2165986712 cites W1771775187 @default.
• W2165986712 cites W1823466978 @default.
• W2165986712 cites W1831769707 @default.
• W2165986712 cites W1845292062 @default.
• W2165986712 cites W1857180626 @default.
• W2165986712 cites W1901642177 @default.
• W2165986712 cites W1945170791 @default.
• W2165986712 cites W1966102221 @default.
• W2165986712 cites W1968489208 @default.
• W2165986712 cites W1979746007 @default.
• W2165986712 cites W1999245676 @default.
• W2165986712 cites W1999503427 @default.
• W2165986712 cites W2003337475 @default.
• W2165986712 cites W2005216817 @default.
• W2165986712 cites W2008301887 @default.
• W2165986712 cites W2008511309 @default.
• W2165986712 cites W2008994306 @default.
• W2165986712 cites W2019594943 @default.
• W2165986712 cites W2022448990 @default.
• W2165986712 cites W2024038175 @default.
• W2165986712 cites W2025204631 @default.
• W2165986712 cites W2029435826 @default.
• W2165986712 cites W2035700498 @default.
• W2165986712 cites W2045213441 @default.
• W2165986712 cites W2047311183 @default.
• W2165986712 cites W2066960349 @default.
• W2165986712 cites W2067605157 @default.
• W2165986712 cites W2073550735 @default.
• W2165986712 cites W2074304171 @default.
• W2165986712 cites W2082493520 @default.
• W2165986712 cites W2097712502 @default.
• W2165986712 cites W2107133310 @default.
• W2165986712 cites W2115477132 @default.
• W2165986712 cites W2118445136 @default.
• W2165986712 cites W2127736630 @default.
• W2165986712 cites W2128051826 @default.
• W2165986712 cites W2128482141 @default.
• W2165986712 cites W2134696618 @default.
• W2165986712 cites W2139547086 @default.
• W2165986712 cites W2140233090 @default.
• W2165986712 cites W2142447693 @default.
• W2165986712 cites W2143325804 @default.
• W2165986712 cites W2143415958 @default.
• W2165986712 cites W2154292013 @default.
• W2165986712 cites W2155186392 @default.
• W2165986712 cites W2158450933 @default.
• W2165986712 cites W2160608142 @default.
• W2165986712 cites W2163990724 @default.
• W2165986712 cites W2166788875 @default.
• W2165986712 cites W2169788254 @default.
• W2165986712 cites W2195257378 @default.
• W2165986712 cites W2318545778 @default.
• W2165986712 doi "https://doi.org/10.1128/iai.02699-14" @default.
• W2165986712 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4294266" @default.
• W2165986712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25422262" @default.
• W2165986712 hasPublicationYear "2015" @default.
• W2165986712 type Work @default.
• W2165986712 sameAs 2165986712 @default.
• W2165986712 citedByCount "28" @default.
• W2165986712 countsByYear W21659867122015 @default.
• W2165986712 countsByYear W21659867122016 @default.
• W2165986712 countsByYear W21659867122017 @default.
• W2165986712 countsByYear W21659867122018 @default.
• W2165986712 countsByYear W21659867122019 @default.
• W2165986712 countsByYear W21659867122020 @default.
• W2165986712 countsByYear W21659867122021 @default.
• W2165986712 countsByYear W21659867122022 @default.
• W2165986712 countsByYear W21659867122023 @default.
• W2165986712 crossrefType "journal-article" @default.
• W2165986712 hasAuthorship W2165986712A5044536494 @default.
• W2165986712 hasAuthorship W2165986712A5067922669 @default.
• W2165986712 hasAuthorship W2165986712A5079637172 @default.
• W2165986712 hasAuthorship W2165986712A5079951129 @default.
• W2165986712 hasBestOaLocation W21659867121 @default.
• W2165986712 hasConcept C147447768 @default.
• W2165986712 hasConcept C203014093 @default.
• W2165986712 hasConcept C204232928 @default.
• W2165986712 hasConcept C2780374374 @default.
• W2165986712 hasConcept C523546767 @default.
• W2165986712 hasConcept C54355233 @default.
• W2165986712 hasConcept C86803240 @default.
• W2165986712 hasConcept C8891405 @default.
• W2165986712 hasConcept C89423630 @default.
• W2165986712 hasConceptScore W2165986712C147447768 @default.
• W2165986712 hasConceptScore W2165986712C203014093 @default.
• W2165986712 hasConceptScore W2165986712C204232928 @default.
• W2165986712 hasConceptScore W2165986712C2780374374 @default.
• W2165986712 hasConceptScore W2165986712C523546767 @default.

• next