FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2165988082> ?p ?o ?g. }

• W2165988082 endingPage "1561" @default.
• W2165988082 startingPage "1551" @default.
• W2165988082 abstract "Susceptibility genes for complex diseases are characterized by reduced penetrance, caused by the influence of other genes, the environment or stochastic events. Recently, positional cloning efforts have yielded several candidate susceptibility genes in different complex disorders such as Crohn's disease and asthma. Within a genetic locus, however, the identification of the effector gene may pose further challenges and require functional studies. I review two examples of such challenges: the cloning of GPR154 (GPRA) and AAA1 on chromosome 7p14 at a susceptibility locus for atopy and asthma, and the study of HLA-Cw6, CCHCR1 (HCR) and CDSN on chromosome 6p21 at PSORS1, the major susceptibility locus for psoriasis. The susceptibility locus for atopy and asthma contains two genes and only one of them is protein coding. We studied its isoform-specific expression in bronchial biopsies and in a mouse model of ovalbumin-induced inflammation of bronchial epithelia. In the PSORS1 locus, strong linkage disequilibrium between genes has made it difficult to distinguish the effects of the three nearby genes. We engineered transgenic mice with either a HCR non-risk allele or the HCR*WWCC risk allele controlled by the cytokeratin-14 promoter. The results suggested that the overexpression of HCR in mouse skin was insufficient to induce a psoriasiform phenotype, but it appeared to induce allele-specific gene expression changes that were similar to those observed in psoriatic skin." @default.
• W2165988082 created "2016-06-24" @default.
• W2165988082 creator A5055564008 @default.
• W2165988082 date "2005-07-25" @default.
• W2165988082 modified "2023-10-18" @default.
• W2165988082 title "Mapping and identifying genes for asthma and psoriasis" @default.
• W2165988082 cites W1485161311 @default.
• W2165988082 cites W1566673175 @default.
• W2165988082 cites W1575215887 @default.
• W2165988082 cites W1598899303 @default.
• W2165988082 cites W1642457845 @default.
• W2165988082 cites W1670573097 @default.
• W2165988082 cites W1786092055 @default.
• W2165988082 cites W1942628795 @default.
• W2165988082 cites W1963693636 @default.
• W2165988082 cites W1964778655 @default.
• W2165988082 cites W1966007013 @default.
• W2165988082 cites W1971951574 @default.
• W2165988082 cites W1979791806 @default.
• W2165988082 cites W1983226456 @default.
• W2165988082 cites W1989814102 @default.
• W2165988082 cites W1993978590 @default.
• W2165988082 cites W2002837591 @default.
• W2165988082 cites W2004725730 @default.
• W2165988082 cites W2015249201 @default.
• W2165988082 cites W2016258379 @default.
• W2165988082 cites W2020446335 @default.
• W2165988082 cites W2022667850 @default.
• W2165988082 cites W2038820441 @default.
• W2165988082 cites W2039114570 @default.
• W2165988082 cites W2040375620 @default.
• W2165988082 cites W2041373197 @default.
• W2165988082 cites W2044105663 @default.
• W2165988082 cites W2046674864 @default.
• W2165988082 cites W2049352641 @default.
• W2165988082 cites W2053559093 @default.
• W2165988082 cites W2054943928 @default.
• W2165988082 cites W2057240156 @default.
• W2165988082 cites W2063014521 @default.
• W2165988082 cites W2070015764 @default.
• W2165988082 cites W2075139637 @default.
• W2165988082 cites W2082744139 @default.
• W2165988082 cites W2092631315 @default.
• W2165988082 cites W2092836731 @default.
• W2165988082 cites W2096063169 @default.
• W2165988082 cites W2097926753 @default.
• W2165988082 cites W2104152486 @default.
• W2165988082 cites W2106846372 @default.
• W2165988082 cites W2113612251 @default.
• W2165988082 cites W2117263999 @default.
• W2165988082 cites W2118479904 @default.
• W2165988082 cites W2123131362 @default.
• W2165988082 cites W2123466824 @default.
• W2165988082 cites W2126142158 @default.
• W2165988082 cites W2126965694 @default.
• W2165988082 cites W2127028166 @default.
• W2165988082 cites W2127265198 @default.
• W2165988082 cites W2131239942 @default.
• W2165988082 cites W2138048215 @default.
• W2165988082 cites W2139762530 @default.
• W2165988082 cites W2140672696 @default.
• W2165988082 cites W2140923468 @default.
• W2165988082 cites W2146374576 @default.
• W2165988082 cites W2147808314 @default.
• W2165988082 cites W2148056869 @default.
• W2165988082 cites W2149870504 @default.
• W2165988082 cites W2159409150 @default.
• W2165988082 cites W2159472846 @default.
• W2165988082 cites W2159567282 @default.
• W2165988082 cites W2162647412 @default.
• W2165988082 cites W2162887826 @default.
• W2165988082 cites W2408484017 @default.
• W2165988082 cites W4285719527 @default.
• W2165988082 cites W46014023 @default.
• W2165988082 cites W596664428 @default.
• W2165988082 doi "https://doi.org/10.1098/rstb.2005.1684" @default.
• W2165988082 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1569524" @default.
• W2165988082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16096103" @default.
• W2165988082 hasPublicationYear "2005" @default.
• W2165988082 type Work @default.
• W2165988082 sameAs 2165988082 @default.
• W2165988082 citedByCount "17" @default.
• W2165988082 countsByYear W21659880822013 @default.
• W2165988082 countsByYear W21659880822014 @default.
• W2165988082 countsByYear W21659880822015 @default.
• W2165988082 countsByYear W21659880822018 @default.
• W2165988082 countsByYear W21659880822022 @default.
• W2165988082 countsByYear W21659880822023 @default.
• W2165988082 crossrefType "journal-article" @default.
• W2165988082 hasAuthorship W2165988082A5055564008 @default.
• W2165988082 hasBestOaLocation W21659880822 @default.
• W2165988082 hasConcept C104317684 @default.
• W2165988082 hasConcept C127716648 @default.
• W2165988082 hasConcept C180754005 @default.
• W2165988082 hasConcept C200544954 @default.
• W2165988082 hasConcept C203014093 @default.
• W2165988082 hasConcept C2776042228 @default.
• W2165988082 hasConcept C2777697326 @default.

• next