Matches in SemOpenAlex for { <https://semopenalex.org/work/W2166004790> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2166004790 endingPage "262" @default.
- W2166004790 startingPage "260" @default.
- W2166004790 abstract "Replication of GWAS association findings remains the gold standard for results validation. Our aim was to test the association of four polymorphisms (rs1671021 in LLGL2, rs753307 in RUVBL2, rs6007897 and rs4044210 in CELSR1) previously identified as ischemic stroke (IS) risk factors in a phased GWAS performed on 6341 Japanese individuals [1].These polymorphisms were genotyped in a Portuguese sample of 566 IS cases and 525 controls, and their allele, genotype and haplotype associations were assessed.rs6007897 and rs4044210 in CELSR1 were associated with stroke risk individually (OR[95%CI]=1.43[1.13-1.81], p=0.003 and 1.38[1.09-1.74], p=0.007, respectively), and in combination as a haplotype. These associations remain after correction for multiple testing and in a meta-analysis with the original findings. The other polymorphisms were not associated.Our study independently confirmed for the first time the association between IS and CELSR1. This finding and the mechanisms by which these genetic variants exert their effects on stroke pathogenesis warrant further replication and investigation." @default.
- W2166004790 created "2016-06-24" @default.
- W2166004790 creator A5015394160 @default.
- W2166004790 creator A5038001100 @default.
- W2166004790 creator A5045860018 @default.
- W2166004790 creator A5053625807 @default.
- W2166004790 creator A5060562722 @default.
- W2166004790 date "2011-07-01" @default.
- W2166004790 modified "2023-09-24" @default.
- W2166004790 title "Replication of the CELSR1 association with ischemic stroke in a Portuguese case-control cohort" @default.
- W2166004790 cites W1993719373 @default.
- W2166004790 cites W2011877873 @default.
- W2166004790 cites W2022394323 @default.
- W2166004790 cites W2055552531 @default.
- W2166004790 cites W2119040073 @default.
- W2166004790 cites W2125886893 @default.
- W2166004790 cites W2140126911 @default.
- W2166004790 cites W2162530578 @default.
- W2166004790 cites W2164954658 @default.
- W2166004790 doi "https://doi.org/10.1016/j.atherosclerosis.2011.03.022" @default.
- W2166004790 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21511255" @default.
- W2166004790 hasPublicationYear "2011" @default.
- W2166004790 type Work @default.
- W2166004790 sameAs 2166004790 @default.
- W2166004790 citedByCount "8" @default.
- W2166004790 countsByYear W21660047902013 @default.
- W2166004790 countsByYear W21660047902014 @default.
- W2166004790 countsByYear W21660047902015 @default.
- W2166004790 countsByYear W21660047902016 @default.
- W2166004790 countsByYear W21660047902017 @default.
- W2166004790 countsByYear W21660047902018 @default.
- W2166004790 countsByYear W21660047902023 @default.
- W2166004790 crossrefType "journal-article" @default.
- W2166004790 hasAuthorship W2166004790A5015394160 @default.
- W2166004790 hasAuthorship W2166004790A5038001100 @default.
- W2166004790 hasAuthorship W2166004790A5045860018 @default.
- W2166004790 hasAuthorship W2166004790A5053625807 @default.
- W2166004790 hasAuthorship W2166004790A5060562722 @default.
- W2166004790 hasBestOaLocation W21660047902 @default.
- W2166004790 hasConcept C104317684 @default.
- W2166004790 hasConcept C106208931 @default.
- W2166004790 hasConcept C127413603 @default.
- W2166004790 hasConcept C135763542 @default.
- W2166004790 hasConcept C153209595 @default.
- W2166004790 hasConcept C180754005 @default.
- W2166004790 hasConcept C186413461 @default.
- W2166004790 hasConcept C197754878 @default.
- W2166004790 hasConcept C2780645631 @default.
- W2166004790 hasConcept C54355233 @default.
- W2166004790 hasConcept C60644358 @default.
- W2166004790 hasConcept C78519656 @default.
- W2166004790 hasConcept C86803240 @default.
- W2166004790 hasConceptScore W2166004790C104317684 @default.
- W2166004790 hasConceptScore W2166004790C106208931 @default.
- W2166004790 hasConceptScore W2166004790C127413603 @default.
- W2166004790 hasConceptScore W2166004790C135763542 @default.
- W2166004790 hasConceptScore W2166004790C153209595 @default.
- W2166004790 hasConceptScore W2166004790C180754005 @default.
- W2166004790 hasConceptScore W2166004790C186413461 @default.
- W2166004790 hasConceptScore W2166004790C197754878 @default.
- W2166004790 hasConceptScore W2166004790C2780645631 @default.
- W2166004790 hasConceptScore W2166004790C54355233 @default.
- W2166004790 hasConceptScore W2166004790C60644358 @default.
- W2166004790 hasConceptScore W2166004790C78519656 @default.
- W2166004790 hasConceptScore W2166004790C86803240 @default.
- W2166004790 hasIssue "1" @default.
- W2166004790 hasLocation W21660047901 @default.
- W2166004790 hasLocation W21660047902 @default.
- W2166004790 hasLocation W21660047903 @default.
- W2166004790 hasOpenAccess W2166004790 @default.
- W2166004790 hasPrimaryLocation W21660047901 @default.
- W2166004790 hasRelatedWork W1982749768 @default.
- W2166004790 hasRelatedWork W2001998019 @default.
- W2166004790 hasRelatedWork W2029361834 @default.
- W2166004790 hasRelatedWork W2038017527 @default.
- W2166004790 hasRelatedWork W2094737836 @default.
- W2166004790 hasRelatedWork W2119763855 @default.
- W2166004790 hasRelatedWork W2744991314 @default.
- W2166004790 hasRelatedWork W4200120858 @default.
- W2166004790 hasRelatedWork W4200206080 @default.
- W2166004790 hasRelatedWork W4242979853 @default.
- W2166004790 hasVolume "217" @default.
- W2166004790 isParatext "false" @default.
- W2166004790 isRetracted "false" @default.
- W2166004790 magId "2166004790" @default.
- W2166004790 workType "article" @default.