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- W2166007002 endingPage "165" @default.
- W2166007002 startingPage "154" @default.
- W2166007002 abstract "Toll-like receptors (TLRs) have been shown to play an important role in the immune system, which warrants study of their remarkable potential as pharmacological targets. Activation of TLRs requires participation from specific pathogen-associated molecular patterns (PAMPs) and accessory proteins such as myeloid differentiation protein 2 (MD2), lipopolysaccharide binding protein (LBP), and cluster differentiation antigen 14 (CD14). Assembly of the TLR4-MD2-LPS complex is essential in TLR4 activation. Recent studies have revealed that TLR4 activation is a significant trigger of signal transmission pathways in the nervous system, which could result in chronic pain as well as opioid tolerance and dependence. Researchers of the molecular structure of TLRs and their accessory proteins have opened a door to syntheses of TLRs agonists and antagonists, such as eritoran. Small-molecule modulators of TLR4, such as MD2-I and tricyclic antidepressants, offer more promising prospects than peptides, given their convenience in oral administration and lower cost. Herein we mainly discuss the mechanisms and clinical prospects of TLR4 agonists and antagonists." @default.
- W2166007002 created "2016-06-24" @default.
- W2166007002 creator A5004224366 @default.
- W2166007002 creator A5016219123 @default.
- W2166007002 creator A5023874102 @default.
- W2166007002 creator A5025581121 @default.
- W2166007002 creator A5090435133 @default.
- W2166007002 date "2015-07-01" @default.
- W2166007002 modified "2023-09-27" @default.
- W2166007002 title "Therapeutic Developments Targeting Toll-like Receptor-4-Mediated Neuroinflammation" @default.
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