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• W2166050886 abstract "Oral bacteria, including S treptococcus mutans and Streptococcus salivarius, contribute to tooth decay and plaque formation; therefore, it is essential to develop strategies to prevent dental caries and plaque formation. We recently showed that organo-selenium compounds covalently attached to different biomaterials inhibited bacterial biofilms. Our current study investigates the efficacy of an organo-selenium dental sealant (SeLECT-Defense TM sealant) in inhibiting S. mutans and S. salivarius biofilm formation in vitro. The organo-selenium was synthesized and covalently attached to dental sealant material via standard polymer chemistry. By colony-forming unit (CFU) assay and confocal microscopy, SeLECT-Defense TM sealant was found to completely inhibit the development of S. mutans and S. salivarius biofilms. To assess the durability of the anti-biofilm effect, we soaked the SeLECT-Defense TM sealant in PBS for 2 mos at 37°C and found that the biofilm-inhibitory effect was not diminished after soaking. To determine if organo-selenium inhibits bacterial growth under the sealant, we placed SeLECT-Defense sealant over a lawn of S. mutans. In contrast to a control sealant, SeLECT-Defense TM sealant completely inhibited the growth of S. mutans. These results suggest that the inhibitory effect of SeLECT-Defense TM sealant against S. mutans and S. salivarius biofilms is very effective and durable." @default.
• W2166050886 created "2016-06-24" @default.
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• W2166050886 date "2013-03-08" @default.
• W2166050886 modified "2023-09-26" @default.
• W2166050886 title "Organo-Selenium-containing Dental Sealant Inhibits Bacterial Biofilm" @default.
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• W2166050886 doi "https://doi.org/10.1177/0022034513482141" @default.
• W2166050886 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3627506" @default.
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