Matches in SemOpenAlex for { <https://semopenalex.org/work/W2166064702> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2166064702 endingPage "3179" @default.
- W2166064702 startingPage "3177" @default.
- W2166064702 abstract "Hepatic insulin resistance manifested as impaired suppression of glucose production is a key metabolic derangement that contributes to fasting hyperglycemia and increased HbA1c levels in type 2 diabetes (1). Genetic manipulation to overexpress the key enzymes in gluconeogenesis (particularly PEPCK) in preclinical models has shown that a primary defect in this system can result in increased hepatic glucose production (2,3) but, importantly, can lead to defects in insulin resistance in other tissues (muscle/fat) and impairments in insulin secretion (4,5). Despite this, medications that specifically target hepatic glucose overproduction in diabetes are lacking. Currently, the only medication (other than insulin) that targets the liver is the biguanide metformin, and despite being used for more than half a century, the mechanism by which it does this is still not completely understood (6–9). Thus, understanding the mechanism causing hepatic insulin resistance will lead to more effective and targeted therapeutic options.Cyclin D1 is involved in cell cycle regulation and DNA synthesis and has been shown to be upregulated in a variety of tumors (including breast cancer). In addition, a number of articles has shown that cyclin D1 can affect metabolic processes, particularly glycolysis, lipogenesis, and mitochondrial function (10–12). Specifically, the loss of cyclin D1 caused an upregulation of hexokinase II, pyruvate kinase, fatty acid synthase, and acetyl-CoA carboxylase, leading to increased lipogenesis. …" @default.
- W2166064702 created "2016-06-24" @default.
- W2166064702 creator A5053988365 @default.
- W2166064702 date "2014-09-15" @default.
- W2166064702 modified "2023-09-26" @default.
- W2166064702 title "The Proliferative Gene Cyclin D1 and Gluconeogenesis—Could Suppressing Glucose Production Also Promote Cancer?" @default.
- W2166064702 cites W1855569674 @default.
- W2166064702 cites W1909063372 @default.
- W2166064702 cites W2010827268 @default.
- W2166064702 cites W2026413615 @default.
- W2166064702 cites W2037918682 @default.
- W2166064702 cites W2047516613 @default.
- W2166064702 cites W2055568030 @default.
- W2166064702 cites W2066819549 @default.
- W2166064702 cites W2079195930 @default.
- W2166064702 cites W2095720556 @default.
- W2166064702 cites W2096730622 @default.
- W2166064702 cites W2119150441 @default.
- W2166064702 cites W2126925408 @default.
- W2166064702 cites W2139860222 @default.
- W2166064702 cites W2144496944 @default.
- W2166064702 doi "https://doi.org/10.2337/db14-0857" @default.
- W2166064702 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25249644" @default.
- W2166064702 hasPublicationYear "2014" @default.
- W2166064702 type Work @default.
- W2166064702 sameAs 2166064702 @default.
- W2166064702 citedByCount "0" @default.
- W2166064702 crossrefType "journal-article" @default.
- W2166064702 hasAuthorship W2166064702A5053988365 @default.
- W2166064702 hasBestOaLocation W21660647021 @default.
- W2166064702 hasConcept C104317684 @default.
- W2166064702 hasConcept C121608353 @default.
- W2166064702 hasConcept C126322002 @default.
- W2166064702 hasConcept C134018914 @default.
- W2166064702 hasConcept C185592680 @default.
- W2166064702 hasConcept C199835354 @default.
- W2166064702 hasConcept C20904676 @default.
- W2166064702 hasConcept C29537977 @default.
- W2166064702 hasConcept C502942594 @default.
- W2166064702 hasConcept C54355233 @default.
- W2166064702 hasConcept C62231903 @default.
- W2166064702 hasConcept C71924100 @default.
- W2166064702 hasConcept C86803240 @default.
- W2166064702 hasConceptScore W2166064702C104317684 @default.
- W2166064702 hasConceptScore W2166064702C121608353 @default.
- W2166064702 hasConceptScore W2166064702C126322002 @default.
- W2166064702 hasConceptScore W2166064702C134018914 @default.
- W2166064702 hasConceptScore W2166064702C185592680 @default.
- W2166064702 hasConceptScore W2166064702C199835354 @default.
- W2166064702 hasConceptScore W2166064702C20904676 @default.
- W2166064702 hasConceptScore W2166064702C29537977 @default.
- W2166064702 hasConceptScore W2166064702C502942594 @default.
- W2166064702 hasConceptScore W2166064702C54355233 @default.
- W2166064702 hasConceptScore W2166064702C62231903 @default.
- W2166064702 hasConceptScore W2166064702C71924100 @default.
- W2166064702 hasConceptScore W2166064702C86803240 @default.
- W2166064702 hasIssue "10" @default.
- W2166064702 hasLocation W21660647021 @default.
- W2166064702 hasLocation W21660647022 @default.
- W2166064702 hasOpenAccess W2166064702 @default.
- W2166064702 hasPrimaryLocation W21660647021 @default.
- W2166064702 hasRelatedWork W1969673257 @default.
- W2166064702 hasRelatedWork W2000010456 @default.
- W2166064702 hasRelatedWork W2064940611 @default.
- W2166064702 hasRelatedWork W2091844621 @default.
- W2166064702 hasRelatedWork W2093559498 @default.
- W2166064702 hasRelatedWork W2110582111 @default.
- W2166064702 hasRelatedWork W2166602509 @default.
- W2166064702 hasRelatedWork W2963017100 @default.
- W2166064702 hasRelatedWork W4246710695 @default.
- W2166064702 hasRelatedWork W2183866174 @default.
- W2166064702 hasVolume "63" @default.
- W2166064702 isParatext "false" @default.
- W2166064702 isRetracted "false" @default.
- W2166064702 magId "2166064702" @default.
- W2166064702 workType "article" @default.