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• W2166066596 abstract "Previous studies have shown that the proanthocyanidin-mediated induction of apoptosis and arrest of the cell cycle in cancer cells was associated with up-regulation of p21Cip1/WAF1 (p21), suggesting that p21 may be the molecular mediator of the observed effects. Here we show that procyanidins induce a rapid and sustained arrest of the cell cycle, and increase apoptosis, concomitant with an increase in p21 expression. However, blocking the PA-induced up-regulation of p21 expression with siRNA did not alter PA-mediated changes in apoptosis and cell cycle, demonstrating that p21 is not responsible for the PA-induced effects." @default.
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• W2166066596 date "2008-11-01" @default.
• W2166066596 modified "2023-09-26" @default.
• W2166066596 title "The procyanidin-mediated induction of apoptosis and cell-cycle arrest in esophageal adenocarcinoma cells is not dependent on p21Cip1/WAF1" @default.
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• W2166066596 doi "https://doi.org/10.1016/j.canlet.2008.05.004" @default.
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