FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2166075017> ?p ?o ?g. }

• W2166075017 endingPage "517" @default.
• W2166075017 startingPage "511" @default.
• W2166075017 abstract "The intraerythrocytic stage of the human malaria parasite <i>Plasmodium falciparum</i> relies on glycolysis for ATP generation, and because it has no energy stores, a constant supply of glucose is necessary for the parasite to grow and multiply. The 2-substituted glucose analogs 2-deoxy-d-glucose (2-DG) and 2-fluoro-2-deoxy-d-glucose (2-FG) have been previously shown to inhibit the in vitro growth of <i>P. falciparum</i> and have been suggested to do so by inhibiting glycosylation in the parasite. In this study, we have investigated the antiplasmodial mechanism of action of 2-DG and 2-FG and compared it with that of other 2-substituted-glucose analogs. The compounds tested inhibited parasite growth to varying degrees, with 2-FG being the most effective. The antiplasmodial activity of some, but not all, of the analogs could be altered by varying the glucose concentration in the culture medium, increasing the antiplasmodial activity of the analogs as the glucose concentration is reduced. A trend was observed between the antiplasmodial activity of these analogs and their ability to inhibit glucose accumulation, glucose phosphorylation by hexokinase, and cytosolic pH regulation within the intraerythrocytic stage of the parasite. Our data are consistent with inhibition of glycolysis being a primary mechanism by which 2-DG and 2-FG inhibit parasite growth, and they validate the early steps in glycolysis as viable drug targets." @default.
• W2166075017 created "2016-06-24" @default.
• W2166075017 creator A5045532469 @default.
• W2166075017 creator A5062959791 @default.
• W2166075017 creator A5075467942 @default.
• W2166075017 date "2008-08-19" @default.
• W2166075017 modified "2023-09-25" @default.
• W2166075017 title "The Inhibitory Effect of 2-Halo Derivatives of d-Glucose on Glycolysis and on the Proliferation of the Human Malaria Parasite<i>Plasmodium falciparum</i>" @default.
• W2166075017 cites W1605920346 @default.
• W2166075017 cites W1970800347 @default.
• W2166075017 cites W1972319281 @default.
• W2166075017 cites W1982694231 @default.
• W2166075017 cites W1983602710 @default.
• W2166075017 cites W1985860330 @default.
• W2166075017 cites W1990951293 @default.
• W2166075017 cites W1991442399 @default.
• W2166075017 cites W1992547036 @default.
• W2166075017 cites W2004830871 @default.
• W2166075017 cites W2005062766 @default.
• W2166075017 cites W2008642071 @default.
• W2166075017 cites W2014878360 @default.
• W2166075017 cites W2016562927 @default.
• W2166075017 cites W2020251171 @default.
• W2166075017 cites W2022738557 @default.
• W2166075017 cites W2034572121 @default.
• W2166075017 cites W2034634278 @default.
• W2166075017 cites W2037024376 @default.
• W2166075017 cites W2037122275 @default.
• W2166075017 cites W2038028457 @default.
• W2166075017 cites W2057922164 @default.
• W2166075017 cites W2060407236 @default.
• W2166075017 cites W2062502531 @default.
• W2166075017 cites W2103072058 @default.
• W2166075017 cites W2105668259 @default.
• W2166075017 cites W2114818342 @default.
• W2166075017 cites W2114971505 @default.
• W2166075017 cites W2115984022 @default.
• W2166075017 cites W2118672167 @default.
• W2166075017 cites W2138645583 @default.
• W2166075017 cites W2159428735 @default.
• W2166075017 cites W2326613008 @default.
• W2166075017 cites W4211035227 @default.
• W2166075017 doi "https://doi.org/10.1124/jpet.108.141929" @default.
• W2166075017 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18713952" @default.
• W2166075017 hasPublicationYear "2008" @default.
• W2166075017 type Work @default.
• W2166075017 sameAs 2166075017 @default.
• W2166075017 citedByCount "48" @default.
• W2166075017 countsByYear W21660750172012 @default.
• W2166075017 countsByYear W21660750172013 @default.
• W2166075017 countsByYear W21660750172014 @default.
• W2166075017 countsByYear W21660750172015 @default.
• W2166075017 countsByYear W21660750172016 @default.
• W2166075017 countsByYear W21660750172017 @default.
• W2166075017 countsByYear W21660750172018 @default.
• W2166075017 countsByYear W21660750172019 @default.
• W2166075017 countsByYear W21660750172020 @default.
• W2166075017 countsByYear W21660750172021 @default.
• W2166075017 countsByYear W21660750172022 @default.
• W2166075017 crossrefType "journal-article" @default.
• W2166075017 hasAuthorship W2166075017A5045532469 @default.
• W2166075017 hasAuthorship W2166075017A5062959791 @default.
• W2166075017 hasAuthorship W2166075017A5075467942 @default.
• W2166075017 hasConcept C136764020 @default.
• W2166075017 hasConcept C181199279 @default.
• W2166075017 hasConcept C185592680 @default.
• W2166075017 hasConcept C20251656 @default.
• W2166075017 hasConcept C202751555 @default.
• W2166075017 hasConcept C203014093 @default.
• W2166075017 hasConcept C2776120743 @default.
• W2166075017 hasConcept C2778048844 @default.
• W2166075017 hasConcept C2778371730 @default.
• W2166075017 hasConcept C2778675580 @default.
• W2166075017 hasConcept C2779826832 @default.
• W2166075017 hasConcept C41008148 @default.
• W2166075017 hasConcept C55493867 @default.
• W2166075017 hasConcept C62231903 @default.
• W2166075017 hasConcept C71928629 @default.
• W2166075017 hasConcept C86803240 @default.
• W2166075017 hasConcept C98539663 @default.
• W2166075017 hasConceptScore W2166075017C136764020 @default.
• W2166075017 hasConceptScore W2166075017C181199279 @default.
• W2166075017 hasConceptScore W2166075017C185592680 @default.
• W2166075017 hasConceptScore W2166075017C20251656 @default.
• W2166075017 hasConceptScore W2166075017C202751555 @default.
• W2166075017 hasConceptScore W2166075017C203014093 @default.
• W2166075017 hasConceptScore W2166075017C2776120743 @default.
• W2166075017 hasConceptScore W2166075017C2778048844 @default.
• W2166075017 hasConceptScore W2166075017C2778371730 @default.
• W2166075017 hasConceptScore W2166075017C2778675580 @default.
• W2166075017 hasConceptScore W2166075017C2779826832 @default.
• W2166075017 hasConceptScore W2166075017C41008148 @default.
• W2166075017 hasConceptScore W2166075017C55493867 @default.
• W2166075017 hasConceptScore W2166075017C62231903 @default.
• W2166075017 hasConceptScore W2166075017C71928629 @default.
• W2166075017 hasConceptScore W2166075017C86803240 @default.
• W2166075017 hasConceptScore W2166075017C98539663 @default.
• W2166075017 hasIssue "2" @default.

• next