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- W2166075354 abstract "The new paradigm of elimination and eradication and constrained economic environment – combined with a first decade of experience – have lead the PATH Malaria Vaccine Initiative (MVI) to redefine its vaccine development strategy. This strategy has two targets: the pre-erythrocytic and sexual stages of the parasite, the latter including the parasite’s evolution inside the mosquito. It encompasses four components: the selection of new antigens, identification of presenting platforms, adjuvant development and vaccine formulation and evaluation technologies. However, the development of a malaria vaccine cannot occur in isolation from other interventions; rather, it should be carried out in coordination with them. RTS,S is now in a Phase III trial, after demonstrating levels of efficacy from 30 to 50% against clinical malaria. Bringing a partially effective vaccine to licensure and use is a long and complex process that will require efficacy as well as public health impact data. Prime-boost and attenuated spor..." @default.
- W2166075354 created "2016-06-24" @default.
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- W2166075354 date "2010-01-01" @default.
- W2166075354 modified "2023-09-26" @default.
- W2166075354 title "Malaria vaccines: current situation, challenges and strategy for the future; a developer’s perspective from the PATH Malaria Vaccine Initiative" @default.
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- W2166075354 doi "https://doi.org/10.2217/thy.09.89" @default.
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