FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2166091933> ?p ?o ?g. }

• W2166091933 endingPage "484" @default.
• W2166091933 startingPage "477" @default.
• W2166091933 abstract "Activation of peroxisome proliferator-activated receptor (PPAR)-γ, a nuclear transcription factor, has been shown to inhibit the production of proinflammatory cytokines and, in peripheral tissues, to downregulate the renin-angiotensin system. PPAR-γ is expressed in key brain areas involved in cardiovascular and autonomic regulation. We hypothesized that activation of central PPAR-γ would reduce sympathetic excitation and ameliorate peripheral manifestations of heart failure (HF) by inhibiting central inflammation and brain renin-angiotensin system activity. Two weeks after coronary artery ligation, HF rats received an intracerebroventricular infusion of the PPAR-γ agonist pioglitazone or vehicle for another 2 weeks. PPAR-γ expression in the paraventricular nucleus of hypothalamus, an important cardiovascular region, was unchanged in HF compared with sham-operated rats. However, PPAR-γ DNA binding activity was reduced, nuclear factor-κB activity was increased, and expression of proinflammatory cytokines and angiotensin II type-1 receptor was augmented in the HF rats. Mean blood pressure response to ganglionic blockade was greater; plasma norepinephrine levels, lung/body weight, right ventricle/body weight, and left ventricular end-diastolic pressure were increased; and maximal left ventricular dP/dt was decreased. All of these findings were ameliorated in HF rats treated with intracerebroventricular pioglitazone, which increased PPAR-γ expression and DNA binding activity in the paraventricular nucleus of hypothalamus. The results demonstrate that cardiovascular and autonomic mechanisms leading to heart failure after myocardial infarction can be modulated by activation of PPAR-γ in the brain. Central PPAR-γ may be a novel target for treatment of sympathetic excitation in myocardial infarction-induced HF." @default.
• W2166091933 created "2016-06-24" @default.
• W2166091933 creator A5013894251 @default.
• W2166091933 creator A5031164641 @default.
• W2166091933 creator A5047580482 @default.
• W2166091933 creator A5060464452 @default.
• W2166091933 creator A5091368710 @default.
• W2166091933 date "2012-02-01" @default.
• W2166091933 modified "2023-10-17" @default.
• W2166091933 title "Peroxisome Proliferator-Activated Receptor-γ Regulates Inflammation and Renin-Angiotensin System Activity in the Hypothalamic Paraventricular Nucleus and Ameliorates Peripheral Manifestations of Heart Failure" @default.
• W2166091933 cites W1570418047 @default.
• W2166091933 cites W1639924204 @default.
• W2166091933 cites W1968900393 @default.
• W2166091933 cites W1970837451 @default.
• W2166091933 cites W1983864692 @default.
• W2166091933 cites W1987840903 @default.
• W2166091933 cites W1988805890 @default.
• W2166091933 cites W1989360250 @default.
• W2166091933 cites W1992123460 @default.
• W2166091933 cites W1993375259 @default.
• W2166091933 cites W1994172493 @default.
• W2166091933 cites W1995606131 @default.
• W2166091933 cites W1997490166 @default.
• W2166091933 cites W1999115295 @default.
• W2166091933 cites W2012378866 @default.
• W2166091933 cites W2014443512 @default.
• W2166091933 cites W2026818910 @default.
• W2166091933 cites W2027307405 @default.
• W2166091933 cites W2027363457 @default.
• W2166091933 cites W2029012272 @default.
• W2166091933 cites W2033367659 @default.
• W2166091933 cites W2034321283 @default.
• W2166091933 cites W2036260872 @default.
• W2166091933 cites W2041144167 @default.
• W2166091933 cites W2042618169 @default.
• W2166091933 cites W2047591801 @default.
• W2166091933 cites W2073874214 @default.
• W2166091933 cites W2077012773 @default.
• W2166091933 cites W2086723085 @default.
• W2166091933 cites W2090936211 @default.
• W2166091933 cites W2091094453 @default.
• W2166091933 cites W2091402272 @default.
• W2166091933 cites W2092454407 @default.
• W2166091933 cites W2092502771 @default.
• W2166091933 cites W2099523487 @default.
• W2166091933 cites W2100677911 @default.
• W2166091933 cites W2101103122 @default.
• W2166091933 cites W2101328058 @default.
• W2166091933 cites W2109011905 @default.
• W2166091933 cites W2109750560 @default.
• W2166091933 cites W2115490015 @default.
• W2166091933 cites W2120533816 @default.
• W2166091933 cites W2121510203 @default.
• W2166091933 cites W2135009079 @default.
• W2166091933 cites W2136644969 @default.
• W2166091933 cites W2141247017 @default.
• W2166091933 cites W2142541950 @default.
• W2166091933 cites W2143961764 @default.
• W2166091933 cites W2146130500 @default.
• W2166091933 cites W2149646115 @default.
• W2166091933 cites W2152170926 @default.
• W2166091933 cites W2154942675 @default.
• W2166091933 cites W2155853691 @default.
• W2166091933 cites W2161910453 @default.
• W2166091933 cites W2162881296 @default.
• W2166091933 cites W2172180641 @default.
• W2166091933 cites W4241468533 @default.
• W2166091933 cites W69623506 @default.
• W2166091933 doi "https://doi.org/10.1161/hypertensionaha.111.182345" @default.
• W2166091933 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3266457" @default.
• W2166091933 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22083161" @default.
• W2166091933 hasPublicationYear "2012" @default.
• W2166091933 type Work @default.
• W2166091933 sameAs 2166091933 @default.
• W2166091933 citedByCount "36" @default.
• W2166091933 countsByYear W21660919332012 @default.
• W2166091933 countsByYear W21660919332013 @default.
• W2166091933 countsByYear W21660919332014 @default.
• W2166091933 countsByYear W21660919332015 @default.
• W2166091933 countsByYear W21660919332016 @default.
• W2166091933 countsByYear W21660919332017 @default.
• W2166091933 countsByYear W21660919332018 @default.
• W2166091933 countsByYear W21660919332019 @default.
• W2166091933 countsByYear W21660919332020 @default.
• W2166091933 countsByYear W21660919332021 @default.
• W2166091933 countsByYear W21660919332022 @default.
• W2166091933 countsByYear W21660919332023 @default.
• W2166091933 crossrefType "journal-article" @default.
• W2166091933 hasAuthorship W2166091933A5013894251 @default.
• W2166091933 hasAuthorship W2166091933A5031164641 @default.
• W2166091933 hasAuthorship W2166091933A5047580482 @default.
• W2166091933 hasAuthorship W2166091933A5060464452 @default.
• W2166091933 hasAuthorship W2166091933A5091368710 @default.
• W2166091933 hasBestOaLocation W21660919331 @default.
• W2166091933 hasConcept C126322002 @default.
• W2166091933 hasConcept C134018914 @default.
• W2166091933 hasConcept C164027704 @default.
• W2166091933 hasConcept C170493617 @default.

• next