Matches in SemOpenAlex for { <https://semopenalex.org/work/W2166098160> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2166098160 abstract "Resident T lymphocytes have been found to exert helper and suppressor regulatory influences with regard to polyclonal activation of murine splenic B lymphocytes elicited by lipopolysaccharide. In the normal adult spleen, only T cell helper influences are exercised over polyclonal B cell activation. This activity is a property of Lyt 1+2- T cells and does not appear to be subject to MHC restriction. Suppressive influence evidently is either latent or it exists at such a low level that its effects are difficult to detect. No regulatory activity can be recovered from the supernatants of T cells, cultured either with or without LPS. However, suppressor T cell function may be evoked by activating splenic T cells with Concanavalin A or by sonicating unstimulated splenic T cells in order to liberate a suppressive potential which is not expressed by these unstimulated cells when intact. The soluble fraction of resident splenic T cell sonicates exerts both helper and suppressor regulatory influences. The soluble helper activity is derived from Lyt l+2- T cells, whereas suppressor activity is generated from Lyt 1-2+ T cells. The suppressive activity of T cell sonicates is not restricted by the MHC gene complex. Helper and suppressor activities contained in splenic T cell sonicates were separated by gel chromatography; the suppressive activity was found to elute with a molecular weight between 68,000 and 84,000 daltons, and the helper activity eluted with a molecular weight between 15,000 and 23,000 daltons. The data indicate that helper and suppressor activities are distinct molecular entities derived from distinct splenic T lymphocyte subpopulations. The possibility that these molecules are precursors to or components of antigen-specific or nonspecific helper and suppressor factors described in the literature is discussed." @default.
- W2166098160 created "2016-06-24" @default.
- W2166098160 creator A5011837566 @default.
- W2166098160 creator A5075544993 @default.
- W2166098160 date "1982-01-01" @default.
- W2166098160 modified "2023-10-17" @default.
- W2166098160 title "The Role of Regulatory Components From Resident T Lymphocytes in Polyclonal B Cell Activation" @default.
- W2166098160 cites W159354068 @default.
- W2166098160 cites W1649854468 @default.
- W2166098160 cites W1964829621 @default.
- W2166098160 cites W1975649472 @default.
- W2166098160 cites W1998062490 @default.
- W2166098160 cites W2001834208 @default.
- W2166098160 cites W2002257677 @default.
- W2166098160 cites W2013117557 @default.
- W2166098160 cites W2017375719 @default.
- W2166098160 cites W2030436366 @default.
- W2166098160 cites W2030698538 @default.
- W2166098160 cites W2043781301 @default.
- W2166098160 cites W2055664612 @default.
- W2166098160 cites W2056280614 @default.
- W2166098160 cites W2084093106 @default.
- W2166098160 cites W2088731565 @default.
- W2166098160 cites W2089522777 @default.
- W2166098160 cites W2104379615 @default.
- W2166098160 cites W2105180943 @default.
- W2166098160 cites W2133923731 @default.
- W2166098160 cites W2134192381 @default.
- W2166098160 cites W2140250150 @default.
- W2166098160 cites W2141155302 @default.
- W2166098160 cites W2141994789 @default.
- W2166098160 doi "https://doi.org/10.1002/jcb.1982.240180402" @default.
- W2166098160 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6211460" @default.
- W2166098160 hasPublicationYear "1982" @default.
- W2166098160 type Work @default.
- W2166098160 sameAs 2166098160 @default.
- W2166098160 citedByCount "3" @default.
- W2166098160 crossrefType "journal-article" @default.
- W2166098160 hasAuthorship W2166098160A5011837566 @default.
- W2166098160 hasAuthorship W2166098160A5075544993 @default.
- W2166098160 hasConcept C104317684 @default.
- W2166098160 hasConcept C147483822 @default.
- W2166098160 hasConcept C153911025 @default.
- W2166098160 hasConcept C179185449 @default.
- W2166098160 hasConcept C185592680 @default.
- W2166098160 hasConcept C19869320 @default.
- W2166098160 hasConcept C202751555 @default.
- W2166098160 hasConcept C203014093 @default.
- W2166098160 hasConcept C207936829 @default.
- W2166098160 hasConcept C2776090121 @default.
- W2166098160 hasConcept C2778754761 @default.
- W2166098160 hasConcept C2780931953 @default.
- W2166098160 hasConcept C2992881475 @default.
- W2166098160 hasConcept C55493867 @default.
- W2166098160 hasConcept C86803240 @default.
- W2166098160 hasConcept C8891405 @default.
- W2166098160 hasConcept C95444343 @default.
- W2166098160 hasConcept C956191 @default.
- W2166098160 hasConceptScore W2166098160C104317684 @default.
- W2166098160 hasConceptScore W2166098160C147483822 @default.
- W2166098160 hasConceptScore W2166098160C153911025 @default.
- W2166098160 hasConceptScore W2166098160C179185449 @default.
- W2166098160 hasConceptScore W2166098160C185592680 @default.
- W2166098160 hasConceptScore W2166098160C19869320 @default.
- W2166098160 hasConceptScore W2166098160C202751555 @default.
- W2166098160 hasConceptScore W2166098160C203014093 @default.
- W2166098160 hasConceptScore W2166098160C207936829 @default.
- W2166098160 hasConceptScore W2166098160C2776090121 @default.
- W2166098160 hasConceptScore W2166098160C2778754761 @default.
- W2166098160 hasConceptScore W2166098160C2780931953 @default.
- W2166098160 hasConceptScore W2166098160C2992881475 @default.
- W2166098160 hasConceptScore W2166098160C55493867 @default.
- W2166098160 hasConceptScore W2166098160C86803240 @default.
- W2166098160 hasConceptScore W2166098160C8891405 @default.
- W2166098160 hasConceptScore W2166098160C95444343 @default.
- W2166098160 hasConceptScore W2166098160C956191 @default.
- W2166098160 hasLocation W21660981601 @default.
- W2166098160 hasLocation W21660981602 @default.
- W2166098160 hasOpenAccess W2166098160 @default.
- W2166098160 hasPrimaryLocation W21660981601 @default.
- W2166098160 hasRelatedWork W1564867503 @default.
- W2166098160 hasRelatedWork W1981011272 @default.
- W2166098160 hasRelatedWork W1986051408 @default.
- W2166098160 hasRelatedWork W2001016015 @default.
- W2166098160 hasRelatedWork W2013719830 @default.
- W2166098160 hasRelatedWork W2039040160 @default.
- W2166098160 hasRelatedWork W2089755029 @default.
- W2166098160 hasRelatedWork W2103009061 @default.
- W2166098160 hasRelatedWork W2166098160 @default.
- W2166098160 hasRelatedWork W2429518082 @default.
- W2166098160 isParatext "false" @default.
- W2166098160 isRetracted "false" @default.
- W2166098160 magId "2166098160" @default.
- W2166098160 workType "article" @default.