Matches in SemOpenAlex for { <https://semopenalex.org/work/W2166110085> ?p ?o ?g. }
- W2166110085 endingPage "362" @default.
- W2166110085 startingPage "355" @default.
- W2166110085 abstract "The Nuclear Factor of Activated T cells (NFAT) plays an important role in innate and adaptive immunity, but no NFAT genes have yet been identified in amphioxus species. Here we identified and characterized an NFAT-like gene from Branchiostoma belcheri, and also studied extensively the evolutionary history of NFAT family genes. We found that the amphioxus genome contains an AmphiNFAT gene encoding an NFAT homolog. The AmphiNFAT gene was found to be involved in the innate immune response to LPS stimulation in B. belcheri and was ubiquitously and differentially expressed in all investigated tissues. The NFAT family genes were present in a common ancestor with cnidaria, and NFAT1-4 paralogs were lost early in Branchiostoma and Strongylocentrotus genomes. We discovered that NFAT family genes underwent strong purifying selection. Taken together, our findings provide an insight into the innate immune response of amphioxus and the evolution of the NFAT gene family." @default.
- W2166110085 created "2016-06-24" @default.
- W2166110085 creator A5034184452 @default.
- W2166110085 creator A5043306934 @default.
- W2166110085 creator A5074859921 @default.
- W2166110085 creator A5078026673 @default.
- W2166110085 creator A5090891386 @default.
- W2166110085 date "2013-10-01" @default.
- W2166110085 modified "2023-10-16" @default.
- W2166110085 title "Identification and evolution of an NFAT gene involving Branchiostoma belcheri innate immunity" @default.
- W2166110085 cites W1492593302 @default.
- W2166110085 cites W1563034495 @default.
- W2166110085 cites W1913751214 @default.
- W2166110085 cites W1919068678 @default.
- W2166110085 cites W1973081749 @default.
- W2166110085 cites W1985442277 @default.
- W2166110085 cites W1988625445 @default.
- W2166110085 cites W1991332015 @default.
- W2166110085 cites W1995193029 @default.
- W2166110085 cites W1997562981 @default.
- W2166110085 cites W2005440337 @default.
- W2166110085 cites W2008208329 @default.
- W2166110085 cites W2012493029 @default.
- W2166110085 cites W2027420168 @default.
- W2166110085 cites W2028211858 @default.
- W2166110085 cites W2039842713 @default.
- W2166110085 cites W2041748354 @default.
- W2166110085 cites W2043114597 @default.
- W2166110085 cites W2045661020 @default.
- W2166110085 cites W2048085771 @default.
- W2166110085 cites W2049656130 @default.
- W2166110085 cites W2059912147 @default.
- W2166110085 cites W2061725286 @default.
- W2166110085 cites W2066222426 @default.
- W2166110085 cites W2073580835 @default.
- W2166110085 cites W2078536849 @default.
- W2166110085 cites W2079491737 @default.
- W2166110085 cites W2080249432 @default.
- W2166110085 cites W2088009450 @default.
- W2166110085 cites W2103546861 @default.
- W2166110085 cites W2110335151 @default.
- W2166110085 cites W2116015828 @default.
- W2166110085 cites W2117110389 @default.
- W2166110085 cites W2132781656 @default.
- W2166110085 cites W2132926880 @default.
- W2166110085 cites W2139857802 @default.
- W2166110085 cites W2146058063 @default.
- W2166110085 cites W2152899800 @default.
- W2166110085 cites W2156482394 @default.
- W2166110085 cites W2157973267 @default.
- W2166110085 cites W2159738116 @default.
- W2166110085 cites W2161054210 @default.
- W2166110085 cites W2167028704 @default.
- W2166110085 cites W2170565120 @default.
- W2166110085 cites W2327006078 @default.
- W2166110085 cites W2417521326 @default.
- W2166110085 doi "https://doi.org/10.1016/j.ygeno.2013.04.019" @default.
- W2166110085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23657135" @default.
- W2166110085 hasPublicationYear "2013" @default.
- W2166110085 type Work @default.
- W2166110085 sameAs 2166110085 @default.
- W2166110085 citedByCount "12" @default.
- W2166110085 countsByYear W21661100852014 @default.
- W2166110085 countsByYear W21661100852015 @default.
- W2166110085 countsByYear W21661100852018 @default.
- W2166110085 countsByYear W21661100852019 @default.
- W2166110085 countsByYear W21661100852020 @default.
- W2166110085 countsByYear W21661100852021 @default.
- W2166110085 countsByYear W21661100852023 @default.
- W2166110085 crossrefType "journal-article" @default.
- W2166110085 hasAuthorship W2166110085A5034184452 @default.
- W2166110085 hasAuthorship W2166110085A5043306934 @default.
- W2166110085 hasAuthorship W2166110085A5074859921 @default.
- W2166110085 hasAuthorship W2166110085A5078026673 @default.
- W2166110085 hasAuthorship W2166110085A5090891386 @default.
- W2166110085 hasBestOaLocation W21661100851 @default.
- W2166110085 hasConcept C104317684 @default.
- W2166110085 hasConcept C136449434 @default.
- W2166110085 hasConcept C141231307 @default.
- W2166110085 hasConcept C189938988 @default.
- W2166110085 hasConcept C54355233 @default.
- W2166110085 hasConcept C5911399 @default.
- W2166110085 hasConcept C86339819 @default.
- W2166110085 hasConcept C86803240 @default.
- W2166110085 hasConcept C8891405 @default.
- W2166110085 hasConceptScore W2166110085C104317684 @default.
- W2166110085 hasConceptScore W2166110085C136449434 @default.
- W2166110085 hasConceptScore W2166110085C141231307 @default.
- W2166110085 hasConceptScore W2166110085C189938988 @default.
- W2166110085 hasConceptScore W2166110085C54355233 @default.
- W2166110085 hasConceptScore W2166110085C5911399 @default.
- W2166110085 hasConceptScore W2166110085C86339819 @default.
- W2166110085 hasConceptScore W2166110085C86803240 @default.
- W2166110085 hasConceptScore W2166110085C8891405 @default.
- W2166110085 hasFunder F4320321001 @default.
- W2166110085 hasFunder F4320327518 @default.
- W2166110085 hasIssue "4" @default.
- W2166110085 hasLocation W21661100851 @default.