FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2166113451> ?p ?o ?g. }

• W2166113451 endingPage "292" @default.
• W2166113451 startingPage "284" @default.
• W2166113451 abstract "The role of different cytochrome P450 enzymes on the metabolism of 3-methylindole (3MI) was investigated using selective chemical inhibitors. Eight chemical inhibitors of P450 enzymes were screened for their inhibitory specificity towards 3MI metabolism in porcine microsomes: alpha-naphthoflavone (CYP1A1/2), 8-methoxypsoralen (CYP2A6), menthofuran (CYP2A6), diethyldithiocarbamate (CYP2A6), 4-methylpyrazole (CYP2E1), sulphaphenazole (CYP2C9), quinidine (CYP2D6), and troleandomycin (CYP3A4). The production of 3MI metabolites was only affected by the presence of inhibitors of CYP2A6 and CYP2E1 in the microsomal incubations. In a second experiment, a set of porcine microsomes (n = 30) was analyzed for CYP2A6 content by protein immunoblot analysis and for their coumarin 7-hydroxylation activity (CYP2A6 activity). Both CYP2A6 content and enzymatic activity were found to be highly and negatively correlated with 3MI fat content. The results of the present study indicate that the CYP2A6 porcine ortholog plays an important role in the metabolism of 3MI and that measurement of CYP2A6 levels and/or activity could be a useful marker for 3MI-induced boar taint." @default.
• W2166113451 created "2016-06-24" @default.
• W2166113451 creator A5037390697 @default.
• W2166113451 creator A5075392235 @default.
• W2166113451 date "2000-06-01" @default.
• W2166113451 modified "2023-10-06" @default.
• W2166113451 title "Metabolism of 3-Methylindole by Porcine Liver Microsomes: Responsible Cytochrome P450 Enzymes" @default.
• W2166113451 cites W1621821829 @default.
• W2166113451 cites W1746765074 @default.
• W2166113451 cites W1823077314 @default.
• W2166113451 cites W1824420684 @default.
• W2166113451 cites W1963675326 @default.
• W2166113451 cites W1963882044 @default.
• W2166113451 cites W1967591957 @default.
• W2166113451 cites W1974733729 @default.
• W2166113451 cites W1978724417 @default.
• W2166113451 cites W1984526747 @default.
• W2166113451 cites W2007972960 @default.
• W2166113451 cites W2009787497 @default.
• W2166113451 cites W2028603080 @default.
• W2166113451 cites W2037812043 @default.
• W2166113451 cites W2051062958 @default.
• W2166113451 cites W2051649196 @default.
• W2166113451 cites W2051725346 @default.
• W2166113451 cites W2094932400 @default.
• W2166113451 cites W2106933588 @default.
• W2166113451 cites W2131614625 @default.
• W2166113451 cites W2136613655 @default.
• W2166113451 cites W2155268095 @default.
• W2166113451 cites W2156851375 @default.
• W2166113451 cites W2202779056 @default.
• W2166113451 cites W2293555888 @default.
• W2166113451 cites W2311788540 @default.
• W2166113451 cites W2399518853 @default.
• W2166113451 cites W2410323725 @default.
• W2166113451 cites W3091984633 @default.
• W2166113451 cites W340453802 @default.
• W2166113451 cites W73439089 @default.
• W2166113451 doi "https://doi.org/10.1093/toxsci/55.2.284" @default.
• W2166113451 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10828259" @default.
• W2166113451 hasPublicationYear "2000" @default.
• W2166113451 type Work @default.
• W2166113451 sameAs 2166113451 @default.
• W2166113451 citedByCount "87" @default.
• W2166113451 countsByYear W21661134512012 @default.
• W2166113451 countsByYear W21661134512013 @default.
• W2166113451 countsByYear W21661134512014 @default.
• W2166113451 countsByYear W21661134512015 @default.
• W2166113451 countsByYear W21661134512016 @default.
• W2166113451 countsByYear W21661134512017 @default.
• W2166113451 countsByYear W21661134512018 @default.
• W2166113451 countsByYear W21661134512020 @default.
• W2166113451 countsByYear W21661134512021 @default.
• W2166113451 countsByYear W21661134512022 @default.
• W2166113451 countsByYear W21661134512023 @default.
• W2166113451 crossrefType "journal-article" @default.
• W2166113451 hasAuthorship W2166113451A5037390697 @default.
• W2166113451 hasAuthorship W2166113451A5075392235 @default.
• W2166113451 hasBestOaLocation W21661134511 @default.
• W2166113451 hasConcept C109650736 @default.
• W2166113451 hasConcept C140027455 @default.
• W2166113451 hasConcept C181199279 @default.
• W2166113451 hasConcept C185592680 @default.
• W2166113451 hasConcept C196013638 @default.
• W2166113451 hasConcept C2780339425 @default.
• W2166113451 hasConcept C2780768313 @default.
• W2166113451 hasConcept C2781109383 @default.
• W2166113451 hasConcept C50605568 @default.
• W2166113451 hasConcept C526171541 @default.
• W2166113451 hasConcept C55493867 @default.
• W2166113451 hasConcept C62231903 @default.
• W2166113451 hasConcept C86803240 @default.
• W2166113451 hasConcept C87644729 @default.
• W2166113451 hasConcept C98274493 @default.
• W2166113451 hasConceptScore W2166113451C109650736 @default.
• W2166113451 hasConceptScore W2166113451C140027455 @default.
• W2166113451 hasConceptScore W2166113451C181199279 @default.
• W2166113451 hasConceptScore W2166113451C185592680 @default.
• W2166113451 hasConceptScore W2166113451C196013638 @default.
• W2166113451 hasConceptScore W2166113451C2780339425 @default.
• W2166113451 hasConceptScore W2166113451C2780768313 @default.
• W2166113451 hasConceptScore W2166113451C2781109383 @default.
• W2166113451 hasConceptScore W2166113451C50605568 @default.
• W2166113451 hasConceptScore W2166113451C526171541 @default.
• W2166113451 hasConceptScore W2166113451C55493867 @default.
• W2166113451 hasConceptScore W2166113451C62231903 @default.
• W2166113451 hasConceptScore W2166113451C86803240 @default.
• W2166113451 hasConceptScore W2166113451C87644729 @default.
• W2166113451 hasConceptScore W2166113451C98274493 @default.
• W2166113451 hasIssue "2" @default.
• W2166113451 hasLocation W21661134511 @default.
• W2166113451 hasLocation W21661134512 @default.
• W2166113451 hasOpenAccess W2166113451 @default.
• W2166113451 hasPrimaryLocation W21661134511 @default.
• W2166113451 hasRelatedWork W1968063155 @default.
• W2166113451 hasRelatedWork W2006346202 @default.
• W2166113451 hasRelatedWork W2022839498 @default.
• W2166113451 hasRelatedWork W2030975106 @default.

• next