FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2166114045> ?p ?o ?g. }

• W2166114045 endingPage "366" @default.
• W2166114045 startingPage "360" @default.
• W2166114045 abstract "Highly purified transverse tubule membranes isolated from frog skeletal muscle phosphorylate phosphatidylinositol to phosphatidylinositol 4-phosphate and phosphatidylinositol (4,5)-bisphosphate. The two phosphorylation reactions have different calcium requirements. Phosphorylation of phosphatidylinositol to phosphatidylinositol 4-phosphate, which takes place in both isolated transverse tubules and sarcoplasmic reticulum membranes, is independent of calcium in a range of concentrations from 10−9 to 10−6m, and is progressively inhibited to 10% of the maximal values by increasing calcium to 10−4m or higher (K0.5 = 5 × 10−6M). In contrast, phosphorylation of phosphatidylinositol 4-phosphate to phosphatidylinositol (4,5)-bisphosphate, a reaction exclusively present in transverse tubule membranes, is maximal at calcium concentrations higher than 2 × 10−6m and decreases to 30% of maximal values at calcium concentrations of 2 × 10−7m or lower (K0.5 = 10−6M). Unlike frog membranes, transverse tubules from rabbit muscle need exogenous phosphatidylinositol 4-phosphate in order to produce the bisphosphate derivative in the same range of calcium concentrations. Inositol (1,4,5)-trisphosphate has been proposed recently as a chemical messenger in excitation-contraction coupling in skeletal muscle. Calcium regulation of the synthesis of phosphatidylinositol (4,5)-bisphosphate, the membrane-bound precursor of inositol (1,4,5)-trisphosphate, might have physiological implications regarding modulation of excitation-contraction coupling by intracellular calcium levels." @default.
• W2166114045 created "2016-06-24" @default.
• W2166114045 creator A5001238861 @default.
• W2166114045 creator A5010563191 @default.
• W2166114045 creator A5045326114 @default.
• W2166114045 creator A5049196516 @default.
• W2166114045 date "1988-04-01" @default.
• W2166114045 modified "2023-10-17" @default.
• W2166114045 title "Calcium modulation of phosphoinositide kinases in transverse tubule vesicles from frog skeletal muscle" @default.
• W2166114045 cites W127059387 @default.
• W2166114045 cites W1506008139 @default.
• W2166114045 cites W1506714695 @default.
• W2166114045 cites W1566113502 @default.
• W2166114045 cites W1965861043 @default.
• W2166114045 cites W1971423696 @default.
• W2166114045 cites W1988363574 @default.
• W2166114045 cites W1989530497 @default.
• W2166114045 cites W1993452826 @default.
• W2166114045 cites W2003671724 @default.
• W2166114045 cites W2003709444 @default.
• W2166114045 cites W2004494622 @default.
• W2166114045 cites W2007655540 @default.
• W2166114045 cites W2008662523 @default.
• W2166114045 cites W2014281089 @default.
• W2166114045 cites W2024929666 @default.
• W2166114045 cites W2029169667 @default.
• W2166114045 cites W2030835955 @default.
• W2166114045 cites W2044287401 @default.
• W2166114045 cites W2055301212 @default.
• W2166114045 cites W2059599236 @default.
• W2166114045 cites W2065128398 @default.
• W2166114045 cites W2067968106 @default.
• W2166114045 cites W2074177402 @default.
• W2166114045 cites W2078070508 @default.
• W2166114045 cites W2080027694 @default.
• W2166114045 cites W2082553691 @default.
• W2166114045 cites W2150530454 @default.
• W2166114045 cites W2325828667 @default.
• W2166114045 cites W4250426224 @default.
• W2166114045 doi "https://doi.org/10.1016/0003-9861(88)90199-3" @default.
• W2166114045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2833175" @default.
• W2166114045 hasPublicationYear "1988" @default.
• W2166114045 type Work @default.
• W2166114045 sameAs 2166114045 @default.
• W2166114045 citedByCount "32" @default.
• W2166114045 crossrefType "journal-article" @default.
• W2166114045 hasAuthorship W2166114045A5001238861 @default.
• W2166114045 hasAuthorship W2166114045A5010563191 @default.
• W2166114045 hasAuthorship W2166114045A5045326114 @default.
• W2166114045 hasAuthorship W2166114045A5049196516 @default.
• W2166114045 hasConcept C11960822 @default.
• W2166114045 hasConcept C12554922 @default.
• W2166114045 hasConcept C134018914 @default.
• W2166114045 hasConcept C163235415 @default.
• W2166114045 hasConcept C170493617 @default.
• W2166114045 hasConcept C178790620 @default.
• W2166114045 hasConcept C185592680 @default.
• W2166114045 hasConcept C2777427919 @default.
• W2166114045 hasConcept C2777853560 @default.
• W2166114045 hasConcept C2779959927 @default.
• W2166114045 hasConcept C2780610907 @default.
• W2166114045 hasConcept C2781387506 @default.
• W2166114045 hasConcept C519063684 @default.
• W2166114045 hasConcept C55493867 @default.
• W2166114045 hasConcept C79879829 @default.
• W2166114045 hasConcept C86803240 @default.
• W2166114045 hasConceptScore W2166114045C11960822 @default.
• W2166114045 hasConceptScore W2166114045C12554922 @default.
• W2166114045 hasConceptScore W2166114045C134018914 @default.
• W2166114045 hasConceptScore W2166114045C163235415 @default.
• W2166114045 hasConceptScore W2166114045C170493617 @default.
• W2166114045 hasConceptScore W2166114045C178790620 @default.
• W2166114045 hasConceptScore W2166114045C185592680 @default.
• W2166114045 hasConceptScore W2166114045C2777427919 @default.
• W2166114045 hasConceptScore W2166114045C2777853560 @default.
• W2166114045 hasConceptScore W2166114045C2779959927 @default.
• W2166114045 hasConceptScore W2166114045C2780610907 @default.
• W2166114045 hasConceptScore W2166114045C2781387506 @default.
• W2166114045 hasConceptScore W2166114045C519063684 @default.
• W2166114045 hasConceptScore W2166114045C55493867 @default.
• W2166114045 hasConceptScore W2166114045C79879829 @default.
• W2166114045 hasConceptScore W2166114045C86803240 @default.
• W2166114045 hasIssue "1" @default.
• W2166114045 hasLocation W21661140451 @default.
• W2166114045 hasLocation W21661140452 @default.
• W2166114045 hasOpenAccess W2166114045 @default.
• W2166114045 hasPrimaryLocation W21661140451 @default.
• W2166114045 hasRelatedWork W1904321711 @default.
• W2166114045 hasRelatedWork W1973540164 @default.
• W2166114045 hasRelatedWork W2018784710 @default.
• W2166114045 hasRelatedWork W2112638018 @default.
• W2166114045 hasRelatedWork W2238525991 @default.
• W2166114045 hasRelatedWork W2333960107 @default.
• W2166114045 hasRelatedWork W2414799073 @default.
• W2166114045 hasRelatedWork W273099659 @default.
• W2166114045 hasRelatedWork W967991370 @default.
• W2166114045 hasRelatedWork W2185380343 @default.
• W2166114045 hasVolume "262" @default.

• next