FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2166115209> ?p ?o ?g. }

• W2166115209 abstract "Preservation of ovarian function following chemotherapy for nonovarian cancers is a formidable challenge. For prepubescent girls, the only option to prevent chemotherapy damage to the ovary is ovarian tissue cryopreservation, an experimental procedure requiring invasive surgeries to harvest and reimplant tissue, which carries the risk of cancer reintroduction. Drugs that block the primary mechanism of chemotherapy insult, such as dexrazoxane (Dexra) in the context of anthracycline chemotherapy, provide a novel approach for ovarian protection and have the potential to overcome current limitations to oncofertility treatment. Dexra is a catalytic topoisomerase 2 inhibitor that protects the mouse ovary from acute doxorubicin (DXR) chemotherapy toxicity in vitro by preventing DXR-induced DNA damage and subsequent gammaH2AX activation. To translate acute DXR ovarian insult and Dexra protection from mouse to nonhuman primate, freshly obtained marmoset ovarian tissue was cultured in vitro and treated with vehicle or 20 μM Dexra 1 h prior to 50 nM DXR. Cultured ovarian tissue was harvested at 2, 4, or 24 h post-DXR treatment. Dexra prevented DXR-induced DNA double-strand breaks as quantified by the neutral comet assay. DXR treatment for 24 h increased gammaH2AX phosphorylation, specifically increasing the number of foci-positive granulosa cells in antral follicles, while Dexra pretreatment inhibited DXR-induced gammaH2AX phosphorylation foci formation. Additionally, Dexra pretreatment trended toward attenuating DXR-induced AKT1 phosphorylation and caspase-9 activation as assayed by Western blots of ovarian tissue lysates. The combined findings suggest Dexra prevents primary DXR-induced DNA damage, the subsequent cellular response to DNA damage, and may diminish early apoptotic signaling in marmoset ovarian tissue. This study provides initial translation of Dexra protection against acute ovarian DXR toxicity from mice to marmoset monkey tissue." @default.
• W2166115209 created "2016-06-24" @default.
• W2166115209 creator A5011737196 @default.
• W2166115209 creator A5038078105 @default.
• W2166115209 creator A5044156215 @default.
• W2166115209 creator A5062429536 @default.
• W2166115209 creator A5083253733 @default.
• W2166115209 date "2015-03-01" @default.
• W2166115209 modified "2023-10-16" @default.
• W2166115209 title "Dexrazoxane Abrogates Acute Doxorubicin Toxicity in Marmoset Ovary1" @default.
• W2166115209 cites W127650315 @default.
• W2166115209 cites W1570743730 @default.
• W2166115209 cites W1967051016 @default.
• W2166115209 cites W1973575405 @default.
• W2166115209 cites W1974232140 @default.
• W2166115209 cites W1979534167 @default.
• W2166115209 cites W1981932258 @default.
• W2166115209 cites W1982545469 @default.
• W2166115209 cites W1990918362 @default.
• W2166115209 cites W1991540594 @default.
• W2166115209 cites W1992121166 @default.
• W2166115209 cites W1993387279 @default.
• W2166115209 cites W1995099027 @default.
• W2166115209 cites W1995316224 @default.
• W2166115209 cites W1995380492 @default.
• W2166115209 cites W2007253523 @default.
• W2166115209 cites W2008757142 @default.
• W2166115209 cites W2026467822 @default.
• W2166115209 cites W2026885876 @default.
• W2166115209 cites W2031421067 @default.
• W2166115209 cites W2032109569 @default.
• W2166115209 cites W2037977021 @default.
• W2166115209 cites W2046984143 @default.
• W2166115209 cites W2051193631 @default.
• W2166115209 cites W2056363035 @default.
• W2166115209 cites W2059565914 @default.
• W2166115209 cites W2062961154 @default.
• W2166115209 cites W2063169831 @default.
• W2166115209 cites W2064530674 @default.
• W2166115209 cites W2070005495 @default.
• W2166115209 cites W2074257515 @default.
• W2166115209 cites W2092986961 @default.
• W2166115209 cites W2096565553 @default.
• W2166115209 cites W2097331847 @default.
• W2166115209 cites W2099615704 @default.
• W2166115209 cites W2100459759 @default.
• W2166115209 cites W2100912472 @default.
• W2166115209 cites W2102304076 @default.
• W2166115209 cites W2107305583 @default.
• W2166115209 cites W2109166024 @default.
• W2166115209 cites W2112357840 @default.
• W2166115209 cites W2117303793 @default.
• W2166115209 cites W2128587010 @default.
• W2166115209 cites W2128776304 @default.
• W2166115209 cites W2129411543 @default.
• W2166115209 cites W2130787407 @default.
• W2166115209 cites W2134748828 @default.
• W2166115209 cites W2135215861 @default.
• W2166115209 cites W2136159364 @default.
• W2166115209 cites W2143426790 @default.
• W2166115209 cites W2146035745 @default.
• W2166115209 cites W2150475243 @default.
• W2166115209 cites W2151686920 @default.
• W2166115209 cites W2152558985 @default.
• W2166115209 cites W2156257249 @default.
• W2166115209 cites W2157932111 @default.
• W2166115209 cites W2160245544 @default.
• W2166115209 cites W2166071570 @default.
• W2166115209 cites W2167824292 @default.
• W2166115209 cites W2172063734 @default.
• W2166115209 cites W2181071030 @default.
• W2166115209 cites W2316402011 @default.
• W2166115209 cites W2325404803 @default.
• W2166115209 cites W4241655843 @default.
• W2166115209 cites W95894433 @default.
• W2166115209 cites W99705021 @default.
• W2166115209 doi "https://doi.org/10.1095/biolreprod.114.119495" @default.
• W2166115209 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4367967" @default.
• W2166115209 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25609833" @default.
• W2166115209 hasPublicationYear "2015" @default.
• W2166115209 type Work @default.
• W2166115209 sameAs 2166115209 @default.
• W2166115209 citedByCount "22" @default.
• W2166115209 countsByYear W21661152092015 @default.
• W2166115209 countsByYear W21661152092016 @default.
• W2166115209 countsByYear W21661152092017 @default.
• W2166115209 countsByYear W21661152092018 @default.
• W2166115209 countsByYear W21661152092019 @default.
• W2166115209 countsByYear W21661152092020 @default.
• W2166115209 countsByYear W21661152092021 @default.
• W2166115209 countsByYear W21661152092022 @default.
• W2166115209 countsByYear W21661152092023 @default.
• W2166115209 crossrefType "journal-article" @default.
• W2166115209 hasAuthorship W2166115209A5011737196 @default.
• W2166115209 hasAuthorship W2166115209A5038078105 @default.
• W2166115209 hasAuthorship W2166115209A5044156215 @default.
• W2166115209 hasAuthorship W2166115209A5062429536 @default.
• W2166115209 hasAuthorship W2166115209A5083253733 @default.
• W2166115209 hasBestOaLocation W21661152092 @default.
• W2166115209 hasConcept C121608353 @default.

• next