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- W2166115760 abstract "The ade6-M26 allele of Schizosaccharomyces pombe creates a well-defined meiotic recombination hot spot that requires a specific sequence, 5′-ATGACGT-3′, and the Atf1•Pcr1 transcription factor for activity. We find that M26 stimulates the formation of meiosis-specific double-strand DNA breaks at multiple sites surrounding M26. Like hot spot activity, breakage requires the M26 heptamer, Pcr1, and the general recombination factor Rec12. When the M26 heptamer is moved to new positions within ade6, new break sites are observed spanning ∼0.5–2 kb around the moved heptamer. Break frequency is strongly correlated with recombination frequency for these alleles. The occurrence of breaks at M26 suggests mechanistic similarities to hot spots in the distantly related yeast Saccharomyces cerevisiae." @default.
- W2166115760 created "2016-06-24" @default.
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- W2166115760 date "2002-04-01" @default.
- W2166115760 modified "2023-10-03" @default.
- W2166115760 title "Meiotic DNA Breaks at the S. pombe Recombination Hot Spot M26" @default.
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- W2166115760 doi "https://doi.org/10.1016/s1097-2765(02)00489-6" @default.
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