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- W2166121787 abstract "Alpha-synuclein (α-syn) is a presynaptic protein that is richly expressed in the central and peripheral nervous systems of mammals, and it is related to the pathogenesis of Parkinson's disease and other neurodegenerative disorders. In the present study, we compared the distribution of the immunoreactivity of α-syn and its related gliosis in the spinal cord of young adult (2-3 years) and aged (10-12 years) beagle dogs. We discovered that α-syn immunoreactivity was present in many neurons in the thoracic level of the aged spinal cord, however, its protein level was not distinct inform that of the adult spinal cord. In addition, ionized calcium-binding adapter molecule-1 (a marker for microglia) immunoreactivity, and not glial fibrillary acidic protein (a marker for astrocytes) immunoreactivity, was somewhat increased in the aged group compared to the adult group. These results indicate that α-syn immunoreactivity was not dramatically changed in the dog spinal cord during aging." @default.
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- W2166121787 date "2012-01-01" @default.
- W2166121787 modified "2023-10-15" @default.
- W2166121787 title "Comparison of alpha-synuclein immunoreactivity in the spinal cord between the adult and aged beagle dog" @default.
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- W2166121787 doi "https://doi.org/10.5625/lar.2012.28.3.165" @default.
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