Matches in SemOpenAlex for { <https://semopenalex.org/work/W2166161018> ?p ?o ?g. }
- W2166161018 endingPage "2279" @default.
- W2166161018 startingPage "2255" @default.
- W2166161018 abstract "Macrophages are important target cells for HIV-1 infection that play significant roles in the maintenance of viral reservoirs and other aspects of pathogenesis. Understanding the determinants of HIV-1 tropism for macrophages will inform HIV-1 control and eradication strategies. Tropism for macrophages is both qualitative (infection or not) and quantitative (replication capacity). For example many R5 HIV-1 isolates cannot infect macrophages, but for those that can the macrophage replication capacity can vary by up to 1000-fold. Some X4 viruses are also capable of replication in macrophages, indicating that cellular tropism is partially independent of co-receptor preference. Preliminary data obtained with a small number of transmitted/founder viruses indicate inefficient macrophage infection, whereas isolates from later in disease are more frequently tropic for macrophages. Thus tropism may evolve over time, and more macrophage tropic viruses may be implicated in the pathogenesis of advanced HIV-1 infection. Compartmentalization of macrophage-tropic brain-derived envelope glycoproteins (Envs), and non-macrophage tropic non-neural tissue-derived Envs points to adaptation of HIV-1 quasi-species in distinct tissue microenvironments. Mutations within and adjacent to the Env-CD4 binding site have been identified that determine macrophage tropism at the entry level, but post-entry molecular determinants of macrophage replication capacity involving HIV-1 accessory proteins need further definition." @default.
- W2166161018 created "2016-06-24" @default.
- W2166161018 creator A5071199689 @default.
- W2166161018 creator A5077123406 @default.
- W2166161018 date "2011-11-15" @default.
- W2166161018 modified "2023-10-01" @default.
- W2166161018 title "Viral Determinants of HIV-1 Macrophage Tropism" @default.
- W2166161018 cites W1514433785 @default.
- W2166161018 cites W1545701301 @default.
- W2166161018 cites W1775967318 @default.
- W2166161018 cites W1963704583 @default.
- W2166161018 cites W1963855922 @default.
- W2166161018 cites W1964017631 @default.
- W2166161018 cites W1964567249 @default.
- W2166161018 cites W1966064265 @default.
- W2166161018 cites W1966382788 @default.
- W2166161018 cites W1969385194 @default.
- W2166161018 cites W1970586339 @default.
- W2166161018 cites W1971278668 @default.
- W2166161018 cites W1971553870 @default.
- W2166161018 cites W1979596307 @default.
- W2166161018 cites W1982410222 @default.
- W2166161018 cites W1982796711 @default.
- W2166161018 cites W1984034687 @default.
- W2166161018 cites W1985859986 @default.
- W2166161018 cites W1987554589 @default.
- W2166161018 cites W1991502041 @default.
- W2166161018 cites W1991586131 @default.
- W2166161018 cites W1992194744 @default.
- W2166161018 cites W1994006101 @default.
- W2166161018 cites W1994473067 @default.
- W2166161018 cites W1998954238 @default.
- W2166161018 cites W2001375348 @default.
- W2166161018 cites W2002574877 @default.
- W2166161018 cites W2002702640 @default.
- W2166161018 cites W2003130463 @default.
- W2166161018 cites W2004335990 @default.
- W2166161018 cites W2009950794 @default.
- W2166161018 cites W2010310827 @default.
- W2166161018 cites W2010458160 @default.
- W2166161018 cites W2010908199 @default.
- W2166161018 cites W2014990531 @default.
- W2166161018 cites W2016625586 @default.
- W2166161018 cites W2016967864 @default.
- W2166161018 cites W2021154383 @default.
- W2166161018 cites W2021195622 @default.
- W2166161018 cites W2026258372 @default.
- W2166161018 cites W2027844128 @default.
- W2166161018 cites W2028968370 @default.
- W2166161018 cites W2029853992 @default.
- W2166161018 cites W2029930485 @default.
- W2166161018 cites W2030692398 @default.
- W2166161018 cites W2033217413 @default.
- W2166161018 cites W2034449118 @default.
- W2166161018 cites W2034996626 @default.
- W2166161018 cites W2037793240 @default.
- W2166161018 cites W2039341131 @default.
- W2166161018 cites W2040139732 @default.
- W2166161018 cites W2042436381 @default.
- W2166161018 cites W2042482120 @default.
- W2166161018 cites W2044393507 @default.
- W2166161018 cites W2046303218 @default.
- W2166161018 cites W2046716698 @default.
- W2166161018 cites W2047452261 @default.
- W2166161018 cites W2049461480 @default.
- W2166161018 cites W2050070282 @default.
- W2166161018 cites W2050860510 @default.
- W2166161018 cites W2051073016 @default.
- W2166161018 cites W2051122335 @default.
- W2166161018 cites W2051200921 @default.
- W2166161018 cites W2051245442 @default.
- W2166161018 cites W2054395379 @default.
- W2166161018 cites W2054839188 @default.
- W2166161018 cites W2055295979 @default.
- W2166161018 cites W2057551492 @default.
- W2166161018 cites W2058618886 @default.
- W2166161018 cites W2060534902 @default.
- W2166161018 cites W2061533648 @default.
- W2166161018 cites W2061769031 @default.
- W2166161018 cites W2064557078 @default.
- W2166161018 cites W2065133594 @default.
- W2166161018 cites W2065210647 @default.
- W2166161018 cites W2065672519 @default.
- W2166161018 cites W2066232369 @default.
- W2166161018 cites W2066504770 @default.
- W2166161018 cites W2067695164 @default.
- W2166161018 cites W2069370553 @default.
- W2166161018 cites W2069554621 @default.
- W2166161018 cites W2069973240 @default.
- W2166161018 cites W2070397094 @default.
- W2166161018 cites W2077057101 @default.
- W2166161018 cites W2078206374 @default.
- W2166161018 cites W2078489697 @default.
- W2166161018 cites W2078701896 @default.
- W2166161018 cites W2086044183 @default.
- W2166161018 cites W2086120330 @default.
- W2166161018 cites W2089692155 @default.
- W2166161018 cites W2095164254 @default.