FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2166164512> ?p ?o ?g. }

• W2166164512 endingPage "4055" @default.
• W2166164512 startingPage "4046" @default.
• W2166164512 abstract "Abstract Th9 cells are a novel Th cell subset that produces IL-9 and is involved in type I hypersensitivity such as airway inflammation. Although its critical roles in asthma have attracted interest, the physiological regulatory mechanisms of Th9 cell differentiation and function are largely unknown. Asthma is easily affected by psychological factors. Therefore, we investigated one of the physiological mediators derived from the nervous system, calcitonin gene-related peptide (CGRP), in asthma and Th9 cells because CGRP and activation of the cAMP/protein kinase A (PKA) pathway by CGRP are known to be important regulators in several immune responses and allergic diseases. In this study, we demonstrated that the CGRP/cAMP/PKA pathway promotes IL-9 production via NFATc2 activation by PKA-dependent glycogen synthase kinase-3β inactivation. Moreover, CGRP also induces the expression of PU.1, a critical transcriptional factor in Th9 cells, which depends on PKA, but not NFATc2. Additionally, we demonstrated the physiological importance of CGRP in IL-9 production and Th9 differentiation using an OVA-induced airway inflammation model and T cell–specific CGRP receptor-deficient mice. The present study revealed a novel regulatory mechanism comprising G protein–coupled receptor ligands and nervous system-derived substances in Th9 cell differentiation and type I hypersensitivity." @default.
• W2166164512 created "2016-06-24" @default.
• W2166164512 creator A5001824238 @default.
• W2166164512 creator A5009725414 @default.
• W2166164512 creator A5027582885 @default.
• W2166164512 creator A5053448001 @default.
• W2166164512 creator A5055812062 @default.
• W2166164512 creator A5065168799 @default.
• W2166164512 creator A5081222997 @default.
• W2166164512 date "2013-04-15" @default.
• W2166164512 modified "2023-10-02" @default.
• W2166164512 title "Calcitonin Gene-Related Peptide and Cyclic Adenosine 5′-Monophosphate/Protein Kinase A Pathway Promote IL-9 Production in Th9 Differentiation Process" @default.
• W2166164512 cites W1525044292 @default.
• W2166164512 cites W1536913980 @default.
• W2166164512 cites W1885709862 @default.
• W2166164512 cites W1967261754 @default.
• W2166164512 cites W1967943295 @default.
• W2166164512 cites W1979542628 @default.
• W2166164512 cites W1981688981 @default.
• W2166164512 cites W1985194414 @default.
• W2166164512 cites W1987528629 @default.
• W2166164512 cites W1991018824 @default.
• W2166164512 cites W1992737431 @default.
• W2166164512 cites W1994428998 @default.
• W2166164512 cites W1999097938 @default.
• W2166164512 cites W2005775152 @default.
• W2166164512 cites W2009022394 @default.
• W2166164512 cites W2012115663 @default.
• W2166164512 cites W2013352622 @default.
• W2166164512 cites W2027699993 @default.
• W2166164512 cites W2028618405 @default.
• W2166164512 cites W2031467805 @default.
• W2166164512 cites W2034196032 @default.
• W2166164512 cites W2039842713 @default.
• W2166164512 cites W2052873213 @default.
• W2166164512 cites W2064718135 @default.
• W2166164512 cites W2070101283 @default.
• W2166164512 cites W2074883812 @default.
• W2166164512 cites W2088275003 @default.
• W2166164512 cites W2090067693 @default.
• W2166164512 cites W2093340080 @default.
• W2166164512 cites W2098509280 @default.
• W2166164512 cites W2103386654 @default.
• W2166164512 cites W2117946656 @default.
• W2166164512 cites W2124566107 @default.
• W2166164512 cites W2125805192 @default.
• W2166164512 cites W2126911875 @default.
• W2166164512 cites W2127009121 @default.
• W2166164512 cites W2129249696 @default.
• W2166164512 cites W2130593605 @default.
• W2166164512 cites W2131012769 @default.
• W2166164512 cites W2131658165 @default.
• W2166164512 cites W2142017607 @default.
• W2166164512 cites W2144823035 @default.
• W2166164512 cites W2147702939 @default.
• W2166164512 cites W2148908122 @default.
• W2166164512 cites W2151185914 @default.
• W2166164512 cites W2151330711 @default.
• W2166164512 cites W2153627394 @default.
• W2166164512 cites W2160128160 @default.
• W2166164512 cites W2163905724 @default.
• W2166164512 cites W2165826409 @default.
• W2166164512 cites W2774336139 @default.
• W2166164512 cites W2784110492 @default.
• W2166164512 cites W4230086548 @default.
• W2166164512 cites W4251919819 @default.
• W2166164512 cites W65155625 @default.
• W2166164512 doi "https://doi.org/10.4049/jimmunol.1203102" @default.
• W2166164512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23509367" @default.
• W2166164512 hasPublicationYear "2013" @default.
• W2166164512 type Work @default.
• W2166164512 sameAs 2166164512 @default.
• W2166164512 citedByCount "31" @default.
• W2166164512 countsByYear W21661645122013 @default.
• W2166164512 countsByYear W21661645122014 @default.
• W2166164512 countsByYear W21661645122015 @default.
• W2166164512 countsByYear W21661645122016 @default.
• W2166164512 countsByYear W21661645122017 @default.
• W2166164512 countsByYear W21661645122019 @default.
• W2166164512 countsByYear W21661645122021 @default.
• W2166164512 countsByYear W21661645122022 @default.
• W2166164512 countsByYear W21661645122023 @default.
• W2166164512 crossrefType "journal-article" @default.
• W2166164512 hasAuthorship W2166164512A5001824238 @default.
• W2166164512 hasAuthorship W2166164512A5009725414 @default.
• W2166164512 hasAuthorship W2166164512A5027582885 @default.
• W2166164512 hasAuthorship W2166164512A5053448001 @default.
• W2166164512 hasAuthorship W2166164512A5055812062 @default.
• W2166164512 hasAuthorship W2166164512A5065168799 @default.
• W2166164512 hasAuthorship W2166164512A5081222997 @default.
• W2166164512 hasBestOaLocation W21661645121 @default.
• W2166164512 hasConcept C104317684 @default.
• W2166164512 hasConcept C118303440 @default.
• W2166164512 hasConcept C148738053 @default.
• W2166164512 hasConcept C163170386 @default.
• W2166164512 hasConcept C170493617 @default.
• W2166164512 hasConcept C184235292 @default.
• W2166164512 hasConcept C185592680 @default.

• next