Matches in SemOpenAlex for { <https://semopenalex.org/work/W2166170153> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2166170153 endingPage "790" @default.
- W2166170153 startingPage "783" @default.
- W2166170153 abstract "We have previously demonstrated that human liver Annexin V (hAV), a Ca2+-dependent phospholipid binding protein, binds specifically to small HBsAg (SHBsAg). Because of the propensity of AV to bind phospholipids, we here examine the role of phospholipids, as component of the HBV envelope, in binding to hAV and in HBV infection.The influence of phospholipids (phosphatidylserine and phosphatidylcholine) on the binding of hAV to SHBsAg or to anti-hAV monoclonals was determined by ELISA. Their influence on HBV infection was investigated using an in vitro HBV infection assay.Two monoclonals, specific against hAV, were able to block the binding of hAV to SHBsAg and recognized different epitopes of hAV. The binding of one of these monoclonals to hAV could be inhibited by phosphatidylserine, but not by phosphatidylcholine. Further experiments revealed that phosphatidylserine could also inhibit the binding of hAV to SHBsAg and could even prevent HBV infection in vitro. Phosphatidylcholine had no effect on the binding of hAV to SHBsAg and could not prevent HBV infection in vitro. However, since phosphatidylserine was not able to abolish the binding of the other blocking monoclonal to hAV, a non-phospholipid component of the HBV envelope must also be involved in hAV binding.These results indicate that phosphatidylserine and a non-phospholipid component of the HBV envelope are involved in hAV binding and in HBV infection." @default.
- W2166170153 created "2016-06-24" @default.
- W2166170153 creator A5011594748 @default.
- W2166170153 creator A5026795331 @default.
- W2166170153 creator A5027623247 @default.
- W2166170153 creator A5063366190 @default.
- W2166170153 creator A5080124451 @default.
- W2166170153 date "1999-11-01" @default.
- W2166170153 modified "2023-09-27" @default.
- W2166170153 title "Involvement of phosphatidylserine and non-phospholipid components of the hepatitis B virus envelope in human Annexin V binding and in HBV infection in vitro" @default.
- W2166170153 cites W1532866634 @default.
- W2166170153 cites W1582315378 @default.
- W2166170153 cites W1594392699 @default.
- W2166170153 cites W1616231937 @default.
- W2166170153 cites W1751218746 @default.
- W2166170153 cites W1969371533 @default.
- W2166170153 cites W1979054624 @default.
- W2166170153 cites W2020958117 @default.
- W2166170153 cites W2043781110 @default.
- W2166170153 cites W2063450941 @default.
- W2166170153 cites W2063970976 @default.
- W2166170153 cites W2068670805 @default.
- W2166170153 cites W2075667536 @default.
- W2166170153 cites W2084169036 @default.
- W2166170153 cites W2089296094 @default.
- W2166170153 cites W2168685020 @default.
- W2166170153 cites W4254445883 @default.
- W2166170153 cites W4294216491 @default.
- W2166170153 cites W2038834839 @default.
- W2166170153 doi "https://doi.org/10.1016/s0168-8278(99)80278-5" @default.
- W2166170153 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10580574" @default.
- W2166170153 hasPublicationYear "1999" @default.
- W2166170153 type Work @default.
- W2166170153 sameAs 2166170153 @default.
- W2166170153 citedByCount "12" @default.
- W2166170153 countsByYear W21661701532014 @default.
- W2166170153 countsByYear W21661701532016 @default.
- W2166170153 countsByYear W21661701532018 @default.
- W2166170153 countsByYear W21661701532020 @default.
- W2166170153 crossrefType "journal-article" @default.
- W2166170153 hasAuthorship W2166170153A5011594748 @default.
- W2166170153 hasAuthorship W2166170153A5026795331 @default.
- W2166170153 hasAuthorship W2166170153A5027623247 @default.
- W2166170153 hasAuthorship W2166170153A5063366190 @default.
- W2166170153 hasAuthorship W2166170153A5080124451 @default.
- W2166170153 hasConcept C153911025 @default.
- W2166170153 hasConcept C159047783 @default.
- W2166170153 hasConcept C185592680 @default.
- W2166170153 hasConcept C202751555 @default.
- W2166170153 hasConcept C2522874641 @default.
- W2166170153 hasConcept C2776330855 @default.
- W2166170153 hasConcept C2777410769 @default.
- W2166170153 hasConcept C2778918659 @default.
- W2166170153 hasConcept C2779637612 @default.
- W2166170153 hasConcept C2780593183 @default.
- W2166170153 hasConcept C41625074 @default.
- W2166170153 hasConcept C55493867 @default.
- W2166170153 hasConcept C86803240 @default.
- W2166170153 hasConcept C88634738 @default.
- W2166170153 hasConcept C97380033 @default.
- W2166170153 hasConceptScore W2166170153C153911025 @default.
- W2166170153 hasConceptScore W2166170153C159047783 @default.
- W2166170153 hasConceptScore W2166170153C185592680 @default.
- W2166170153 hasConceptScore W2166170153C202751555 @default.
- W2166170153 hasConceptScore W2166170153C2522874641 @default.
- W2166170153 hasConceptScore W2166170153C2776330855 @default.
- W2166170153 hasConceptScore W2166170153C2777410769 @default.
- W2166170153 hasConceptScore W2166170153C2778918659 @default.
- W2166170153 hasConceptScore W2166170153C2779637612 @default.
- W2166170153 hasConceptScore W2166170153C2780593183 @default.
- W2166170153 hasConceptScore W2166170153C41625074 @default.
- W2166170153 hasConceptScore W2166170153C55493867 @default.
- W2166170153 hasConceptScore W2166170153C86803240 @default.
- W2166170153 hasConceptScore W2166170153C88634738 @default.
- W2166170153 hasConceptScore W2166170153C97380033 @default.
- W2166170153 hasIssue "5" @default.
- W2166170153 hasLocation W21661701531 @default.
- W2166170153 hasLocation W21661701532 @default.
- W2166170153 hasOpenAccess W2166170153 @default.
- W2166170153 hasPrimaryLocation W21661701531 @default.
- W2166170153 hasRelatedWork W1886563198 @default.
- W2166170153 hasRelatedWork W2059651550 @default.
- W2166170153 hasRelatedWork W2062835383 @default.
- W2166170153 hasRelatedWork W2083315302 @default.
- W2166170153 hasRelatedWork W2087379950 @default.
- W2166170153 hasRelatedWork W2133015002 @default.
- W2166170153 hasRelatedWork W2186027547 @default.
- W2166170153 hasRelatedWork W2252971779 @default.
- W2166170153 hasRelatedWork W2333742820 @default.
- W2166170153 hasRelatedWork W2952320777 @default.
- W2166170153 hasVolume "31" @default.
- W2166170153 isParatext "false" @default.
- W2166170153 isRetracted "false" @default.
- W2166170153 magId "2166170153" @default.
- W2166170153 workType "article" @default.