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- W2166197577 abstract "The effects of pretreatment with the κ-agonists U-50,488H (U-50) and E-2078 on the morphine (MRP)-induced conditioned place preference (CPP) were examined in mice. Both U-50 (1 mg/kg, s.c.) and E-2078 (0.1 mg/kg, s.c.) induced a slight, non-significant place aversion. Pretreatment with U-50 (1 mg/kg) or E-2078 (0.1 mg/kg) abolished the MRP (3 mg/kg, s.c.)-induced CPP. In addition, MRP (3 mg/kg, s.c.) significantly increased the levels of the DA metabolites, DOPAC and HVA in the limbic forebrain (nucleus accumbens and olfactory tubercle). These effects were reduced by pretreatment with U-50. These results suggest that κ-agonists suppress the MRP-induced CPP, and that activation of κ-receptors could suppress the reinforcing effects of MRP which may be induced by enhanced DA transmission in the mesolimbic DA system." @default.
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- W2166197577 date "1994-02-01" @default.
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- W2166197577 title "Blockade of morphine-induced place preference through the activation of κ-opioid receptors in mice" @default.
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- W2166197577 doi "https://doi.org/10.1016/0167-0115(94)90310-7" @default.
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