Matches in SemOpenAlex for { <https://semopenalex.org/work/W2166236611> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2166236611 endingPage "E998" @default.
- W2166236611 startingPage "E993" @default.
- W2166236611 abstract "Hypoalbuminemia is accompanied by hypercholesterolemia in both nephrotic syndrome and hereditary analbuminemia. Hypercholesterolemia is more severe in the female than in the male Nagase analbuminemic rats (NAR). The sex difference in plasma cholesterol diminishes after ovariectomy (OVX) and reappears after estrogen replacement in the NAR. The molecular mechanism responsible for the sex difference in severity of hypercholesterolemia in NAR is not known and was investigated here. To this end, hepatic hydroxylmethylglutaryl (HMG)-CoA reductase, cholesterol 7α-hydroxylase, and LDL receptor were determined in male, female, and OVX female NAR and Sprague-Dawley (SD) rats. Plasma cholesterol, triglycerides, and hepatic HMG-CoA reductase activities were greater in both female and male NAR than in SD rats. This was coupled with upregulation of cholesterol 7α-hydroxylase in both male and female NAR compared with SD controls. LDL receptor in male NAR was similar to that in male SD rats but was significantly reduced in female NAR. OVX partially, but significantly, reduced plasma cholesterol and triglyceride levels in female NAR. This was coupled with a significant rise in hepatic cholesterol 7α-hydroxylase and a modest increase in hepatic LDL receptor. In contrast, OVX resulted in a mild elevation of plasma cholesterol and no significant changes in total hepatic HMG-CoA reductase, cholesterol 7α-hydroxylase, or LDL receptor in female SD rats. Thus the greater severity of hypercholesterolemia in the female NAR appears to be due, in part, to a combination of the constrained compensatory upregulation of cholesterol 7α-hydroxylase and LDL receptor deficiency." @default.
- W2166236611 created "2016-06-24" @default.
- W2166236611 creator A5037214521 @default.
- W2166236611 creator A5056238061 @default.
- W2166236611 creator A5062438369 @default.
- W2166236611 creator A5064364225 @default.
- W2166236611 creator A5074932828 @default.
- W2166236611 date "2005-12-01" @default.
- W2166236611 modified "2023-09-24" @default.
- W2166236611 title "Effects of gender on hepatic HMG-CoA reductase, cholesterol 7α-hydroxylase, and LDL receptor in hereditary analbuminemia" @default.
- W2166236611 cites W1954011026 @default.
- W2166236611 cites W1980878393 @default.
- W2166236611 cites W1999115022 @default.
- W2166236611 cites W2030897902 @default.
- W2166236611 cites W2045743441 @default.
- W2166236611 cites W2048385749 @default.
- W2166236611 cites W2048544365 @default.
- W2166236611 cites W2075226611 @default.
- W2166236611 cites W2075705443 @default.
- W2166236611 cites W2076364750 @default.
- W2166236611 cites W2079797979 @default.
- W2166236611 cites W2085309008 @default.
- W2166236611 cites W2109938153 @default.
- W2166236611 cites W2110966479 @default.
- W2166236611 cites W2128900773 @default.
- W2166236611 cites W2144258483 @default.
- W2166236611 cites W2146544318 @default.
- W2166236611 cites W2147357183 @default.
- W2166236611 cites W2156305802 @default.
- W2166236611 cites W2397646680 @default.
- W2166236611 doi "https://doi.org/10.1152/ajpendo.00037.2005" @default.
- W2166236611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16030068" @default.
- W2166236611 hasPublicationYear "2005" @default.
- W2166236611 type Work @default.
- W2166236611 sameAs 2166236611 @default.
- W2166236611 citedByCount "14" @default.
- W2166236611 countsByYear W21662366112012 @default.
- W2166236611 countsByYear W21662366112015 @default.
- W2166236611 countsByYear W21662366112020 @default.
- W2166236611 crossrefType "journal-article" @default.
- W2166236611 hasAuthorship W2166236611A5037214521 @default.
- W2166236611 hasAuthorship W2166236611A5056238061 @default.
- W2166236611 hasAuthorship W2166236611A5062438369 @default.
- W2166236611 hasAuthorship W2166236611A5064364225 @default.
- W2166236611 hasAuthorship W2166236611A5074932828 @default.
- W2166236611 hasConcept C104950815 @default.
- W2166236611 hasConcept C126322002 @default.
- W2166236611 hasConcept C134018914 @default.
- W2166236611 hasConcept C134651460 @default.
- W2166236611 hasConcept C181199279 @default.
- W2166236611 hasConcept C185592680 @default.
- W2166236611 hasConcept C2778163477 @default.
- W2166236611 hasConcept C2779120738 @default.
- W2166236611 hasConcept C2780072125 @default.
- W2166236611 hasConcept C43554185 @default.
- W2166236611 hasConcept C55493867 @default.
- W2166236611 hasConcept C71924100 @default.
- W2166236611 hasConcept C86803240 @default.
- W2166236611 hasConceptScore W2166236611C104950815 @default.
- W2166236611 hasConceptScore W2166236611C126322002 @default.
- W2166236611 hasConceptScore W2166236611C134018914 @default.
- W2166236611 hasConceptScore W2166236611C134651460 @default.
- W2166236611 hasConceptScore W2166236611C181199279 @default.
- W2166236611 hasConceptScore W2166236611C185592680 @default.
- W2166236611 hasConceptScore W2166236611C2778163477 @default.
- W2166236611 hasConceptScore W2166236611C2779120738 @default.
- W2166236611 hasConceptScore W2166236611C2780072125 @default.
- W2166236611 hasConceptScore W2166236611C43554185 @default.
- W2166236611 hasConceptScore W2166236611C55493867 @default.
- W2166236611 hasConceptScore W2166236611C71924100 @default.
- W2166236611 hasConceptScore W2166236611C86803240 @default.
- W2166236611 hasIssue "6" @default.
- W2166236611 hasLocation W21662366111 @default.
- W2166236611 hasLocation W21662366112 @default.
- W2166236611 hasOpenAccess W2166236611 @default.
- W2166236611 hasPrimaryLocation W21662366111 @default.
- W2166236611 hasRelatedWork W173114256 @default.
- W2166236611 hasRelatedWork W1966834268 @default.
- W2166236611 hasRelatedWork W2026060498 @default.
- W2166236611 hasRelatedWork W2030755023 @default.
- W2166236611 hasRelatedWork W2089889877 @default.
- W2166236611 hasRelatedWork W2165140407 @default.
- W2166236611 hasRelatedWork W2166236611 @default.
- W2166236611 hasRelatedWork W2171600145 @default.
- W2166236611 hasRelatedWork W2748952813 @default.
- W2166236611 hasRelatedWork W3146713193 @default.
- W2166236611 hasVolume "289" @default.
- W2166236611 isParatext "false" @default.
- W2166236611 isRetracted "false" @default.
- W2166236611 magId "2166236611" @default.
- W2166236611 workType "article" @default.