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- W2166237978 abstract "To analyze the mechanism by which interferon (IFN)–α is effective against human T cell lymphotropic virus type I (HTLV-I)–associated myelopathy/tropical spastic paraparesis (HAM/TSP), we investigated the T cell phenotype and HTLV-I provirus load in peripheral blood mononuclear cells from 25 patients with HAM/TSP that were obtained before and after administration of IFN-α. The frequency of memory (CD45RA−CD27+) T cells that were CD8high+, CXCR3+ cell populations, and HTLV-I provirus loads were significantly decreased after treatment. The proportion of memory T cells in the CD8high+ cell population correlated well with HTLV-I provirus load, whereas the proportion of effector (CD45RA+CD27−) cells in the CD8high+ cell population was inversely correlated with provirus load. Interestingly, the frequency of perforin expression in CD8high+ cells was significantly decreased after treatment in patients who experienced clinical improvement, whereas patients who did not experience clinical improvement showed an increased frequency of perforin expression. Our data suggest that fluctuations in these cell subsets are associated with both the immunomodulatory effect of IFN-α and the observed clinical benefit of IFN-α treatment in patients with HAM/TSP" @default.
- W2166237978 created "2016-06-24" @default.
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- W2166237978 date "2004-01-01" @default.
- W2166237978 modified "2023-10-10" @default.
- W2166237978 title "Decreased Human T Lymphotropic Virus Type I (HTLV‐I) Provirus Load and Alteration in T Cell Phenotype after Interferon‐α Therapy for HTLV‐I–Associated Myelopathy/Tropical Spastic Paraparesis" @default.
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- W2166237978 doi "https://doi.org/10.1086/380101" @default.
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