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- W2166254228 abstract "Role of TGF-β on cardiac structural and electrical remodeling Roberto Ramos-Mondragón, Carlos A Galindo, Guillermo AvilaDepartamento de Bioquímica, Cinvestav-IPN, MéxicoAbstract: The type β transforming growth factors (TGF-βs) are involved in a number of human diseases, including heart failure and myocardial arrhythmias. In fact, during the last 20 years numerous studies have demonstrated that TGF-β affects the architecture of the heart under both normal and pathological conditions. Moreover, TGF-β signaling is currently under investigation, with the aim of discovering potential therapeutic roles in human disease. In contrast, only few studies have investigated whether TGF-β affects electrophysiological properties of the heart. This fact is surprising since electrical remodeling represents an important substrate for cardiac disease. This review discusses the potential role of TGF-β on cardiac excitation-contraction (EC) coupling, action potentials, and ion channels. We also discuss the effects of TGF-β on cardiac development and disease from structural and electrophysiological points of view.Keywords: transforming growth factor, ion channel, cardiac electrophysiology" @default.
- W2166254228 created "2016-06-24" @default.
- W2166254228 creator A5034149986 @default.
- W2166254228 creator A5058861501 @default.
- W2166254228 creator A5085119624 @default.
- W2166254228 date "2008-12-01" @default.
- W2166254228 modified "2023-10-17" @default.
- W2166254228 title "Role of TGF-β on cardiac structural and electrical remodeling" @default.
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