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• W2166256145 abstract "CD4+CD25low/-GITR+ T lymphocytes expressing forkhead box protein P3 (FoxP3) and showing regulatory activity have been recently described in healthy donors. The objective of the study was to evaluate the proportion of CD4+CD25low/-GITR+ T lymphocytes within CD4+ T cells and compare their phenotypic and functional profile with that of CD4+CD25highGITR- T lymphocytes in systemic lupus erythematosus (SLE) patients. The percentage of CD4+CD25low/-GITR+ cells circulating in the peripheral blood (PB) of 32 patients with SLE and 25 healthy controls was evaluated with flow cytometry. CD4+CD25low/-GITR+ cells were isolated with magnetic separation, and their phenotype was compared with that of CD4+CD25highGITR- cells. Regulatory activity of both cell subsets was tested in autologous and heterologous co-cultures after purification through a negative sorting strategy. Results indicated that CD4+CD25low/-GITR+ cells are expanded in the PB of 50% of SLE patients. Expansion was observed only in patients with inactive disease. Phenotypic analysis demonstrated that CD4+CD25low/-GITR+ cells display regulatory T-cell (Treg) markers, including FoxP3, cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), transforming growth factor-beta (TGF-β), and interleukin (IL)-10. In contrast, CD4+CD25highGITR- cells appear to be activated and express low levels of Treg markers. Functional experiments demonstrated that CD4+CD25low/-GITR+ cells exert a higher inhibitory activity against both autologous and heterologous cells as compared with CD4+CD25highGITR- cells. Suppression is independent of cell contact and is mediated by IL-10 and TGF-β. Phenotypic and functional data demonstrate that in SLE patients, CD4+CD25low/-GITR+ cells are fully active Treg cells, possibly representing peripheral Treg (pTreg) that are expanded in patients with inactive disease. These data may suggest a key role of this T-cell subset in the modulation of the abnormal immune response in SLE. Strategies aimed at expanding this Treg subset for therapeutic purpose deserve to be investigated." @default.
• W2166256145 created "2016-06-24" @default.
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• W2166256145 date "2014-09-26" @default.
• W2166256145 modified "2023-10-14" @default.
• W2166256145 title "Expansion of regulatory GITR+CD25low/-CD4+ T cells in systemic lupus erythematosus patients" @default.
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• W2166256145 doi "https://doi.org/10.1186/s13075-014-0444-x" @default.
• W2166256145 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4209023" @default.
• W2166256145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25256257" @default.
• W2166256145 hasPublicationYear "2014" @default.
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