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- W2166281502 startingPage "4" @default.
- W2166281502 abstract "Thrombosis is a deadly malfunctioning of the hemostatic system occurring in numerous conditions and states, from surgery and pregnancy to cancer, sepsis and infarction. Despite availability of antithrombotic agents and vast clinical experience justifying their use, thrombosis is still responsible for a lion’s share of mortality and morbidity in the modern world. One of the key reasons behind this is notorious insensitivity of traditional coagulation assays to hypercoagulation and their inability to evaluate thrombotic risks; specific molecular markers are more successful but suffer from numerous disadvantages. A possible solution is proposed by use of global, or integral, assays that aim to mimic and reflect the major physiological aspects of hemostasis process in vitro. Here we review the existing evidence regarding the ability of both established and novel global assays (thrombin generation, thrombelastography, thrombodynamics, flow perfusion chambers) to evaluate thrombotic risk in specific disorders. The biochemical nature of this risk and its detectability by analysis of blood state in principle are also discussed. We conclude that existing global assays have a potential to be an important tool of hypercoagulation diagnostics. However, their lack of standardization currently impedes their application: different assays and different modifications of each assay vary in their sensitivity and specificity for each specific pathology. In addition, it remains to be seen how their sensitivity to hypercoagulation (even when they can reliably detect groups with different risk of thrombosis) can be used for clinical decisions: the risk difference between such groups is statistically significant, but not large." @default.
- W2166281502 created "2016-06-24" @default.
- W2166281502 creator A5052198022 @default.
- W2166281502 creator A5057748570 @default.
- W2166281502 date "2015-01-01" @default.
- W2166281502 modified "2023-09-26" @default.
- W2166281502 title "Global assays of hemostasis in the diagnostics of hypercoagulation and evaluation of thrombosis risk" @default.
- W2166281502 cites W122408613 @default.
- W2166281502 cites W1481834866 @default.
- W2166281502 cites W1531281563 @default.
- W2166281502 cites W1537546222 @default.
- W2166281502 cites W1571397203 @default.
- W2166281502 cites W1584325646 @default.
- W2166281502 cites W1621550101 @default.
- W2166281502 cites W1906965387 @default.
- W2166281502 cites W1964632235 @default.
- W2166281502 cites W1967085308 @default.
- W2166281502 cites W1969736058 @default.
- W2166281502 cites W1970393874 @default.
- W2166281502 cites W1971014130 @default.
- W2166281502 cites W1971877681 @default.
- W2166281502 cites W1972649534 @default.
- W2166281502 cites W1973687787 @default.
- W2166281502 cites W1975554781 @default.
- W2166281502 cites W1976519721 @default.
- W2166281502 cites W1976624290 @default.
- W2166281502 cites W1976835885 @default.
- W2166281502 cites W1978890822 @default.
- W2166281502 cites W1980474192 @default.
- W2166281502 cites W1980948936 @default.
- W2166281502 cites W1982221334 @default.
- W2166281502 cites W1984681193 @default.
- W2166281502 cites W1984930166 @default.
- W2166281502 cites W1985187618 @default.
- W2166281502 cites W1987931239 @default.
- W2166281502 cites W1989515923 @default.
- W2166281502 cites W1992319328 @default.
- W2166281502 cites W1993627870 @default.
- W2166281502 cites W1994689749 @default.
- W2166281502 cites W2001692920 @default.
- W2166281502 cites W200264917 @default.
- W2166281502 cites W2003714769 @default.
- W2166281502 cites W2003976858 @default.
- W2166281502 cites W2005897453 @default.
- W2166281502 cites W2006884867 @default.
- W2166281502 cites W2009416484 @default.
- W2166281502 cites W2010735426 @default.
- W2166281502 cites W2011784685 @default.
- W2166281502 cites W2012535096 @default.
- W2166281502 cites W2013658408 @default.
- W2166281502 cites W2022265090 @default.
- W2166281502 cites W2026648151 @default.
- W2166281502 cites W2031458609 @default.
- W2166281502 cites W2032524450 @default.
- W2166281502 cites W2037931805 @default.
- W2166281502 cites W2040254529 @default.
- W2166281502 cites W2040865519 @default.
- W2166281502 cites W2041726150 @default.
- W2166281502 cites W2043434342 @default.
- W2166281502 cites W2044224479 @default.
- W2166281502 cites W2044496603 @default.
- W2166281502 cites W2048027358 @default.
- W2166281502 cites W2048329222 @default.
- W2166281502 cites W2050063493 @default.
- W2166281502 cites W2055063721 @default.
- W2166281502 cites W2055170504 @default.
- W2166281502 cites W2056425903 @default.
- W2166281502 cites W2057262694 @default.
- W2166281502 cites W2058217708 @default.
- W2166281502 cites W2058297756 @default.
- W2166281502 cites W2059747315 @default.
- W2166281502 cites W2060508448 @default.
- W2166281502 cites W2063215578 @default.
- W2166281502 cites W2066746471 @default.
- W2166281502 cites W2067161993 @default.
- W2166281502 cites W2070891258 @default.
- W2166281502 cites W2071039800 @default.
- W2166281502 cites W2071305684 @default.
- W2166281502 cites W2074410191 @default.
- W2166281502 cites W2074475417 @default.
- W2166281502 cites W2078774601 @default.
- W2166281502 cites W2080423166 @default.
- W2166281502 cites W2084827367 @default.
- W2166281502 cites W2086387232 @default.
- W2166281502 cites W2086544626 @default.
- W2166281502 cites W2090371144 @default.
- W2166281502 cites W2090488720 @default.
- W2166281502 cites W2092530980 @default.
- W2166281502 cites W2095601555 @default.
- W2166281502 cites W2101085536 @default.
- W2166281502 cites W2101250198 @default.
- W2166281502 cites W2101371933 @default.
- W2166281502 cites W2102243498 @default.
- W2166281502 cites W2105676528 @default.
- W2166281502 cites W2106351507 @default.
- W2166281502 cites W2110172512 @default.
- W2166281502 cites W2111966177 @default.
- W2166281502 cites W2114152867 @default.