Matches in SemOpenAlex for { <https://semopenalex.org/work/W2166312842> ?p ?o ?g. }
- W2166312842 endingPage "3200" @default.
- W2166312842 startingPage "3192" @default.
- W2166312842 abstract "Abstract The ETV6-NTRK3 (EN) chimeric tyrosine kinase, a potent oncoprotein expressed in tumors derived from multiple cell lineages, functions as a constitutively active protein-tyrosine kinase. ETV6-NTRK expression leads to the constitutive activation of two major effector pathways of wild-type NTRK3, namely, the Ras–mitogen-activated protein kinase (MAPK) mitogenic pathway and the phosphoinositide-3-kinase (PI3K)-Akt pathway mediating cell survival, and both are required for EN transformation. However, it remains unclear how ETV6-NTRK3 activates Ras-Erk1/2 and/or PI3K-Akt cascades. Here, we define some aspects of the molecular mechanisms regulating ETV6-NTRK–dependent Ras-Erk1/2 and PI3K-Akt activation. We show that ETV6-NTRK3 associates with c-Src, and that treatment with SU6656, a c-Src inhibitor, completely blocks ETV6-NTRK-transforming activity. Treatment of NIH3T3 cells expressing ETV6-NTRK3 with SU6656 attenuated the activation of Ras-Erk1/2 and PI3K-Akt. Suppression of c-Src by RNA interference in NIH3T3-ETV6-NTRK3 cells resulted in markedly decreased expression of cyclin D1 and suppression of activation of Ras-Erk1/2 and PI3K-Akt. However, in Src-deficient cells, the ETV6-NTRK3 failed to activate the PI3K-Atk pathway, but not the Ras-Erk1/2 pathway. Therefore, these data indicate that ETV6-NTRK3 induces the PI3K-Akt cascade through the activation of c-Src. [Cancer Res 2007;67(7):3192–200]" @default.
- W2166312842 created "2016-06-24" @default.
- W2166312842 creator A5002922209 @default.
- W2166312842 creator A5007471022 @default.
- W2166312842 creator A5015141034 @default.
- W2166312842 creator A5022279675 @default.
- W2166312842 creator A5074879945 @default.
- W2166312842 creator A5083608565 @default.
- W2166312842 date "2007-04-01" @default.
- W2166312842 modified "2023-10-02" @default.
- W2166312842 title "Cellular Transformation and Activation of the Phosphoinositide-3-Kinase–Akt Cascade by the ETV6-NTRK3 Chimeric Tyrosine Kinase Requires c-Src" @default.
- W2166312842 cites W1488039334 @default.
- W2166312842 cites W1559197668 @default.
- W2166312842 cites W1594020010 @default.
- W2166312842 cites W1606885912 @default.
- W2166312842 cites W1789215739 @default.
- W2166312842 cites W1854123316 @default.
- W2166312842 cites W1973577899 @default.
- W2166312842 cites W1976059757 @default.
- W2166312842 cites W1989480480 @default.
- W2166312842 cites W1991371485 @default.
- W2166312842 cites W1996776596 @default.
- W2166312842 cites W1996987411 @default.
- W2166312842 cites W2001521752 @default.
- W2166312842 cites W2008018118 @default.
- W2166312842 cites W2025248134 @default.
- W2166312842 cites W2026279585 @default.
- W2166312842 cites W2035555871 @default.
- W2166312842 cites W2052371969 @default.
- W2166312842 cites W2053449922 @default.
- W2166312842 cites W2054582733 @default.
- W2166312842 cites W2059221693 @default.
- W2166312842 cites W2061252595 @default.
- W2166312842 cites W2071230526 @default.
- W2166312842 cites W2074674534 @default.
- W2166312842 cites W2074830772 @default.
- W2166312842 cites W2084082316 @default.
- W2166312842 cites W2090347711 @default.
- W2166312842 cites W2094173028 @default.
- W2166312842 cites W2104485296 @default.
- W2166312842 cites W2108502873 @default.
- W2166312842 cites W2117563665 @default.
- W2166312842 cites W2128960139 @default.
- W2166312842 cites W2132755748 @default.
- W2166312842 cites W2137921390 @default.
- W2166312842 cites W2140272347 @default.
- W2166312842 cites W2142728728 @default.
- W2166312842 cites W2142962849 @default.
- W2166312842 cites W2154025598 @default.
- W2166312842 cites W2170054765 @default.
- W2166312842 cites W2294291334 @default.
- W2166312842 cites W2322632282 @default.
- W2166312842 doi "https://doi.org/10.1158/0008-5472.can-06-3526" @default.
- W2166312842 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17409427" @default.
- W2166312842 hasPublicationYear "2007" @default.
- W2166312842 type Work @default.
- W2166312842 sameAs 2166312842 @default.
- W2166312842 citedByCount "34" @default.
- W2166312842 countsByYear W21663128422012 @default.
- W2166312842 countsByYear W21663128422013 @default.
- W2166312842 countsByYear W21663128422014 @default.
- W2166312842 countsByYear W21663128422015 @default.
- W2166312842 countsByYear W21663128422017 @default.
- W2166312842 countsByYear W21663128422018 @default.
- W2166312842 countsByYear W21663128422020 @default.
- W2166312842 countsByYear W21663128422021 @default.
- W2166312842 countsByYear W21663128422022 @default.
- W2166312842 countsByYear W21663128422023 @default.
- W2166312842 crossrefType "journal-article" @default.
- W2166312842 hasAuthorship W2166312842A5002922209 @default.
- W2166312842 hasAuthorship W2166312842A5007471022 @default.
- W2166312842 hasAuthorship W2166312842A5015141034 @default.
- W2166312842 hasAuthorship W2166312842A5022279675 @default.
- W2166312842 hasAuthorship W2166312842A5074879945 @default.
- W2166312842 hasAuthorship W2166312842A5083608565 @default.
- W2166312842 hasBestOaLocation W21663128422 @default.
- W2166312842 hasConcept C101544691 @default.
- W2166312842 hasConcept C108636557 @default.
- W2166312842 hasConcept C153911025 @default.
- W2166312842 hasConcept C185592680 @default.
- W2166312842 hasConcept C42362537 @default.
- W2166312842 hasConcept C502942594 @default.
- W2166312842 hasConcept C62478195 @default.
- W2166312842 hasConcept C75217442 @default.
- W2166312842 hasConcept C86554907 @default.
- W2166312842 hasConcept C86803240 @default.
- W2166312842 hasConcept C95444343 @default.
- W2166312842 hasConceptScore W2166312842C101544691 @default.
- W2166312842 hasConceptScore W2166312842C108636557 @default.
- W2166312842 hasConceptScore W2166312842C153911025 @default.
- W2166312842 hasConceptScore W2166312842C185592680 @default.
- W2166312842 hasConceptScore W2166312842C42362537 @default.
- W2166312842 hasConceptScore W2166312842C502942594 @default.
- W2166312842 hasConceptScore W2166312842C62478195 @default.
- W2166312842 hasConceptScore W2166312842C75217442 @default.
- W2166312842 hasConceptScore W2166312842C86554907 @default.
- W2166312842 hasConceptScore W2166312842C86803240 @default.
- W2166312842 hasConceptScore W2166312842C95444343 @default.