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• W2166321360 abstract "Abstract Stem cells, which can self‐renew and give rise to differentiated daughters, are responsible for the generation of diverse cell types during development and the maintenance of tissue/organ homeostasis in adulthood. Thus, the precise regulation of stem‐cell self‐renewal and proliferative potential is a key aspect of development. The stem‐cell niche confers such control by concentrating localized factors including signaling molecules which favor stem‐cell self‐renew and regulate stem‐cell proliferation in line with developmental programs. In contrast, Drosophila neuroblasts (NBs), often referred to as neural stem cells/progenitors, can undergo asymmetric cell division to self‐renew and produce differentiated daughters even in isolation (or in culture). Furthermore, these isolated NBs can also progress through an intrinsically regulated temporal series (of transcription factor expression) to generate diverse cell types in vitro . These data argue that NBs may depend only to a limited extent, if at all, on local environment (a niche) for their maintenance. On the other hand, there is increasing evidence which indicate that the interaction between NBs and their surrounding glia is critical for the control of NB proliferative potential and these glia, in conjunction with systemic regulation, perform the niche function to regulate NB behavior. Thus, these observations emphasize the importance of coordinated local microenvironment (niche activity) and systemic environment (global activity) on the regulation of NB behavior in vivo , and suggest NBs may conform to an alternative stem‐cell/progenitor maintenance model. WIREs Dev Biol 2012, 1:307–314. doi: 10.1002/wdev.27 This article is categorized under: Nervous System Development > Flies Adult Stem Cells, Tissue Renewal, and Regeneration > Tissue Stem Cells and Niches Adult Stem Cells, Tissue Renewal, and Regeneration > Environmental Control of Stem Cells" @default.
• W2166321360 created "2016-06-24" @default.
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• W2166321360 date "2011-12-27" @default.
• W2166321360 modified "2023-10-16" @default.
• W2166321360 title "A niche for<i>Drosophila</i>neuroblasts?" @default.
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• W2166321360 doi "https://doi.org/10.1002/wdev.27" @default.
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