Matches in SemOpenAlex for { <https://semopenalex.org/work/W2166363828> ?p ?o ?g. }
- W2166363828 endingPage "1067" @default.
- W2166363828 startingPage "1058" @default.
- W2166363828 abstract "Bi-directional calcium (Ca 2+ ) signaling between mitochondria and intracellular stores (endoplasmic/sarcoplasmic reticulum) underlies important cellular functions, including oxidative ATP production. In striated muscle, this coupling is achieved by mitochondria being located adjacent to Ca 2+ stores (sarcoplasmic reticulum [SR]) and in proximity of release sites (Ca 2+ release units [CRUs]). However, limited information is available with regard to the mechanisms of mitochondrial-SR coupling. Using electron microscopy and electron tomography, we identified small bridges, or tethers, that link the outer mitochondrial membrane to the intracellular Ca 2+ stores of muscle. This association is sufficiently strong that treatment with hypotonic solution results in stretching of the SR membrane in correspondence of tethers. We also show that the association of mitochondria to the SR is 1) developmentally regulated, 2) involves a progressive shift from a longitudinal clustering at birth to a specific CRU-coupled transversal orientation in adult, and 3) results in a change in the mitochondrial polarization state, as shown by confocal imaging after JC1 staining. Our results suggest that tethers 1) establish and maintain SR–mitochondrial association during postnatal maturation and in adult muscle and 2) likely provide a structural framework for bi-directional signaling between the two organelles in striated muscle." @default.
- W2166363828 created "2016-06-24" @default.
- W2166363828 creator A5016522052 @default.
- W2166363828 creator A5032282263 @default.
- W2166363828 creator A5043113234 @default.
- W2166363828 creator A5064460348 @default.
- W2166363828 creator A5067632956 @default.
- W2166363828 creator A5077847134 @default.
- W2166363828 creator A5090295114 @default.
- W2166363828 date "2009-02-01" @default.
- W2166363828 modified "2023-10-10" @default.
- W2166363828 title "Mitochondria Are Linked to Calcium Stores in Striated Muscle by Developmentally Regulated Tethering Structures" @default.
- W2166363828 cites W1522450427 @default.
- W2166363828 cites W1590434874 @default.
- W2166363828 cites W163606371 @default.
- W2166363828 cites W1971255655 @default.
- W2166363828 cites W1975351203 @default.
- W2166363828 cites W1988185301 @default.
- W2166363828 cites W1995076624 @default.
- W2166363828 cites W2001607813 @default.
- W2166363828 cites W2001828266 @default.
- W2166363828 cites W2005308044 @default.
- W2166363828 cites W2018415759 @default.
- W2166363828 cites W2032659837 @default.
- W2166363828 cites W2034862605 @default.
- W2166363828 cites W2041539014 @default.
- W2166363828 cites W2043286970 @default.
- W2166363828 cites W2044375393 @default.
- W2166363828 cites W2046196975 @default.
- W2166363828 cites W2046353863 @default.
- W2166363828 cites W2048995238 @default.
- W2166363828 cites W2060811345 @default.
- W2166363828 cites W2063059690 @default.
- W2166363828 cites W2065383397 @default.
- W2166363828 cites W2067338987 @default.
- W2166363828 cites W2074766103 @default.
- W2166363828 cites W2080312195 @default.
- W2166363828 cites W2090659633 @default.
- W2166363828 cites W2092510248 @default.
- W2166363828 cites W2099388247 @default.
- W2166363828 cites W2108762727 @default.
- W2166363828 cites W2115322996 @default.
- W2166363828 cites W2121330845 @default.
- W2166363828 cites W2123671636 @default.
- W2166363828 cites W2136864660 @default.
- W2166363828 cites W2338134953 @default.
- W2166363828 cites W2411983669 @default.
- W2166363828 cites W2415208667 @default.
- W2166363828 doi "https://doi.org/10.1091/mbc.e08-07-0783" @default.
- W2166363828 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2633377" @default.
- W2166363828 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19037102" @default.
- W2166363828 hasPublicationYear "2009" @default.
- W2166363828 type Work @default.
- W2166363828 sameAs 2166363828 @default.
- W2166363828 citedByCount "238" @default.
- W2166363828 countsByYear W21663638282012 @default.
- W2166363828 countsByYear W21663638282013 @default.
- W2166363828 countsByYear W21663638282014 @default.
- W2166363828 countsByYear W21663638282015 @default.
- W2166363828 countsByYear W21663638282016 @default.
- W2166363828 countsByYear W21663638282017 @default.
- W2166363828 countsByYear W21663638282018 @default.
- W2166363828 countsByYear W21663638282019 @default.
- W2166363828 countsByYear W21663638282020 @default.
- W2166363828 countsByYear W21663638282021 @default.
- W2166363828 countsByYear W21663638282022 @default.
- W2166363828 countsByYear W21663638282023 @default.
- W2166363828 crossrefType "journal-article" @default.
- W2166363828 hasAuthorship W2166363828A5016522052 @default.
- W2166363828 hasAuthorship W2166363828A5032282263 @default.
- W2166363828 hasAuthorship W2166363828A5043113234 @default.
- W2166363828 hasAuthorship W2166363828A5064460348 @default.
- W2166363828 hasAuthorship W2166363828A5067632956 @default.
- W2166363828 hasAuthorship W2166363828A5077847134 @default.
- W2166363828 hasAuthorship W2166363828A5090295114 @default.
- W2166363828 hasBestOaLocation W21663638282 @default.
- W2166363828 hasConcept C126322002 @default.
- W2166363828 hasConcept C158617107 @default.
- W2166363828 hasConcept C168240541 @default.
- W2166363828 hasConcept C181080969 @default.
- W2166363828 hasConcept C201571599 @default.
- W2166363828 hasConcept C207200792 @default.
- W2166363828 hasConcept C28859421 @default.
- W2166363828 hasConcept C519063684 @default.
- W2166363828 hasConcept C71924100 @default.
- W2166363828 hasConcept C79879829 @default.
- W2166363828 hasConcept C86803240 @default.
- W2166363828 hasConcept C95444343 @default.
- W2166363828 hasConceptScore W2166363828C126322002 @default.
- W2166363828 hasConceptScore W2166363828C158617107 @default.
- W2166363828 hasConceptScore W2166363828C168240541 @default.
- W2166363828 hasConceptScore W2166363828C181080969 @default.
- W2166363828 hasConceptScore W2166363828C201571599 @default.
- W2166363828 hasConceptScore W2166363828C207200792 @default.
- W2166363828 hasConceptScore W2166363828C28859421 @default.
- W2166363828 hasConceptScore W2166363828C519063684 @default.
- W2166363828 hasConceptScore W2166363828C71924100 @default.
- W2166363828 hasConceptScore W2166363828C79879829 @default.