FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2166366945> ?p ?o ?g. }

• W2166366945 endingPage "116" @default.
• W2166366945 startingPage "108" @default.
• W2166366945 abstract "Benzene is an important industrial chemical that is also widely present in cigarette smoke, automobile exhaust, and gasoline. It is reported that benzene can cause hematopoietic disorders and has been recognized as a human carcinogen. However, the mechanisms by which it increases the risk of carcinogenesis are only partially understood. Aberrant DNA methylation is a major epigenetic mechanism associated with the toxicity of carcinogens. To understand the carcinogenic capacity of benzene, experiments were designed to investigate whether exposure to benzene and its metabolites would change the global DNA methylation status in human normal hepatic L02 cells and then to evaluate whether the changes would be induced by variation of DNA methyltransferase (DNMT) activity in HaeIII DNMT‐mediated methylation assay in vitro . Our results showed that hydroquinone and 1,4‐benzoquinone could induce global DNA hypomethylation with statistically significant difference from control ( p < 0.05), but no significant global DNA methylation changes were observed in L02 cells with benzene, phenol, and 1,2,4‐trihydroxybenzene exposure. Benzene metabolites could not influence HaeIII DNMT activity except that 1,4‐benzoquinone shows significantly inhibiting effect on enzymatic methylation reaction at concentrations of 5 μM ( p < 0.05). These results suggest that benzene metabolites, hydroquinone, and 1,4‐benzoquinone can disrupt global DNA methylation, and the potential epigenetic mechanism by which that global DNA hypomethylation induced by 1,4‐benzoquinone may work through the inhibiting effects of DNMT activity at 10 μM ( p < 0.05). © 2011 Wiley Periodicals, Inc. Environ Toxicol 29: 108–116, 2014." @default.
• W2166366945 created "2016-06-24" @default.
• W2166366945 creator A5016681175 @default.
• W2166366945 creator A5021945689 @default.
• W2166366945 creator A5033545758 @default.
• W2166366945 creator A5036365752 @default.
• W2166366945 creator A5083974787 @default.
• W2166366945 creator A5085478486 @default.
• W2166366945 date "2011-09-23" @default.
• W2166366945 modified "2023-10-07" @default.
• W2166366945 title "Effects of benzene and its metabolites on global DNA methylation in human normal hepatic l02 cells" @default.
• W2166366945 cites W1980817813 @default.
• W2166366945 cites W1982814037 @default.
• W2166366945 cites W1990381590 @default.
• W2166366945 cites W1991557335 @default.
• W2166366945 cites W1992055191 @default.
• W2166366945 cites W2001425587 @default.
• W2166366945 cites W2002420533 @default.
• W2166366945 cites W2022502456 @default.
• W2166366945 cites W2022610928 @default.
• W2166366945 cites W2026123032 @default.
• W2166366945 cites W2040407637 @default.
• W2166366945 cites W2041165812 @default.
• W2166366945 cites W2046994100 @default.
• W2166366945 cites W2062753668 @default.
• W2166366945 cites W2071207437 @default.
• W2166366945 cites W2078500739 @default.
• W2166366945 cites W2084410329 @default.
• W2166366945 cites W2085561926 @default.
• W2166366945 cites W2086412617 @default.
• W2166366945 cites W2093520294 @default.
• W2166366945 cites W2110175547 @default.
• W2166366945 cites W2135471644 @default.
• W2166366945 cites W2138751912 @default.
• W2166366945 cites W2142669349 @default.
• W2166366945 cites W2163061363 @default.
• W2166366945 cites W2413239008 @default.
• W2166366945 cites W4251549090 @default.
• W2166366945 doi "https://doi.org/10.1002/tox.20777" @default.
• W2166366945 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21953684" @default.
• W2166366945 hasPublicationYear "2011" @default.
• W2166366945 type Work @default.
• W2166366945 sameAs 2166366945 @default.
• W2166366945 citedByCount "37" @default.
• W2166366945 countsByYear W21663669452014 @default.
• W2166366945 countsByYear W21663669452015 @default.
• W2166366945 countsByYear W21663669452016 @default.
• W2166366945 countsByYear W21663669452017 @default.
• W2166366945 countsByYear W21663669452019 @default.
• W2166366945 countsByYear W21663669452020 @default.
• W2166366945 countsByYear W21663669452021 @default.
• W2166366945 countsByYear W21663669452022 @default.
• W2166366945 countsByYear W21663669452023 @default.
• W2166366945 crossrefType "journal-article" @default.
• W2166366945 hasAuthorship W2166366945A5016681175 @default.
• W2166366945 hasAuthorship W2166366945A5021945689 @default.
• W2166366945 hasAuthorship W2166366945A5033545758 @default.
• W2166366945 hasAuthorship W2166366945A5036365752 @default.
• W2166366945 hasAuthorship W2166366945A5083974787 @default.
• W2166366945 hasAuthorship W2166366945A5085478486 @default.
• W2166366945 hasConcept C104317684 @default.
• W2166366945 hasConcept C114246631 @default.
• W2166366945 hasConcept C150194340 @default.
• W2166366945 hasConcept C153911025 @default.
• W2166366945 hasConcept C178790620 @default.
• W2166366945 hasConcept C185592680 @default.
• W2166366945 hasConcept C190727270 @default.
• W2166366945 hasConcept C2777691172 @default.
• W2166366945 hasConcept C2779686393 @default.
• W2166366945 hasConcept C2779979206 @default.
• W2166366945 hasConcept C33288867 @default.
• W2166366945 hasConcept C41091548 @default.
• W2166366945 hasConcept C552990157 @default.
• W2166366945 hasConcept C55493867 @default.
• W2166366945 hasConcept C555283112 @default.
• W2166366945 hasConcept C86803240 @default.
• W2166366945 hasConcept C91965660 @default.
• W2166366945 hasConceptScore W2166366945C104317684 @default.
• W2166366945 hasConceptScore W2166366945C114246631 @default.
• W2166366945 hasConceptScore W2166366945C150194340 @default.
• W2166366945 hasConceptScore W2166366945C153911025 @default.
• W2166366945 hasConceptScore W2166366945C178790620 @default.
• W2166366945 hasConceptScore W2166366945C185592680 @default.
• W2166366945 hasConceptScore W2166366945C190727270 @default.
• W2166366945 hasConceptScore W2166366945C2777691172 @default.
• W2166366945 hasConceptScore W2166366945C2779686393 @default.
• W2166366945 hasConceptScore W2166366945C2779979206 @default.
• W2166366945 hasConceptScore W2166366945C33288867 @default.
• W2166366945 hasConceptScore W2166366945C41091548 @default.
• W2166366945 hasConceptScore W2166366945C552990157 @default.
• W2166366945 hasConceptScore W2166366945C55493867 @default.
• W2166366945 hasConceptScore W2166366945C555283112 @default.
• W2166366945 hasConceptScore W2166366945C86803240 @default.
• W2166366945 hasConceptScore W2166366945C91965660 @default.
• W2166366945 hasIssue "1" @default.
• W2166366945 hasLocation W21663669451 @default.
• W2166366945 hasLocation W21663669452 @default.
• W2166366945 hasOpenAccess W2166366945 @default.

• next