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- W2166367025 abstract "It is now well established that a GnRH agonist (GnRHa) ovulation trigger completely prevents ovarian hyperstimulation syndrome. However, early studies, using conventional luteal support, showed inferior clinical results following a GnRHa trigger compared with a conventional hCG trigger in normal responder IVF patients. We here present a novel approach for luteal support after a GnRHa trigger. Normal responder patients who failed at least one previous IVF attempt, during which a conventional hCG trigger was used, were consecutively enrolled in the study. A GnRH antagonist-based ovarian stimulation protocol was used in combination with a GnRHa trigger (Triptorelin 0.2 mg). The luteal phase was supported with a total of two boluses of 1500 IU hCG: on the day of oocyte retrieval and 4 days later. Neither progesterone nor estradiol was administered for luteal support. The mean age was 33.8 years. The mean (±SD) numbers of oocytes and fertilized oocytes were 6.7 (±2.5) and 3.6 (±1.7), respectively. All 15 patients had embryo transfers and 11 patients conceived. On the day of pregnancy test (14 days after retrieval), the mean serum E2 and progesterone levels were 6607 (±3789) and 182 (±50) nmol/l, respectively. Of the pregnancies, seven are ongoing, while four ended as miscarriages. These preliminary results suggest that two boluses of 1500 IU hCG revert the luteolysis after a GnRHa trigger in the normo-responder patient. Importantly, no additional luteal support is needed. The novel concept combines the potential advantages of a physiological dual trigger (LH and FSH) with a simple, patient friendly, luteal support." @default.
- W2166367025 created "2016-06-24" @default.
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- W2166367025 creator A5019658630 @default.
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- W2166367025 date "2011-07-21" @default.
- W2166367025 modified "2023-09-23" @default.
- W2166367025 title "GnRH agonist ovulation trigger and hCG-based, progesterone-free luteal support: a proof of concept study" @default.
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- W2166367025 doi "https://doi.org/10.1093/humrep/der220" @default.
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