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• W2166416819 abstract "Abstract Silent Night : Antagonism of the orexin (or hypocretin) system has recently been identified as a novel mechanism for the treatment of insomnia. Herein, we describe discovery of a dual (OX 1 R/OX 2 R) orexin receptor antagonist featuring a 1,4‐diazepane central constraint that blocks orexin signaling in vivo. In telemetry‐implanted rats, oral administration of this antagonist produced a decrease in wakefulness, while increasing REM and non‐REM sleep. magnified image" @default.
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• W2166416819 date "2009-06-29" @default.
• W2166416819 modified "2023-10-15" @default.
• W2166416819 title "Discovery of a Potent, CNS‐Penetrant Orexin Receptor Antagonist Based on an <i>N</i>,<i>N</i>‐Disubstituted‐1,4‐diazepane Scaffold that Promotes Sleep in Rats" @default.
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• W2166416819 doi "https://doi.org/10.1002/cmdc.200900069" @default.
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