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- W2166431352 abstract "The main objective of the study was to identify proteomic markers, expressed in serum of mice after prime boost strategies using BCG as priming agent followed by booster doses with BCG, Ag85B and also Ag- 85complex peptide. Mice serum samples were subjected for two dimensional electrophoresis based on which, we identified number of biomarkers. Some were found to down regulate after primary BCG vaccination but were again expressed after booster doses with Ag85 B and Ag85 peptide but not with BCG. We also identified some proteomic markers that were specifically expressed only after booster doses with BCG, Ag85B and Ag85 peptide. To conclude, serum proteomic profil- ing provides us useful information in identification of biomarkers. Characterization of such protein bands further by LC-MS in near future will help us in identification of such surrogate biomarkers which can be correlated with improved efficacy of prime boost vaccination strategies." @default.
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- W2166431352 date "2011-10-01" @default.
- W2166431352 modified "2023-09-25" @default.
- W2166431352 title "Proteomic Approach to Identify Surrogate Biomarkers for Evaluation of Efficacy After Prime Boost Vaccination" @default.
- W2166431352 doi "https://doi.org/10.15373/2249555x/apr2013/151" @default.
- W2166431352 hasPublicationYear "2011" @default.
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