FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2166475162> ?p ?o ?g. }

• W2166475162 endingPage "371" @default.
• W2166475162 startingPage "361" @default.
• W2166475162 abstract "The TCR signals are essential for T cell activation and proliferation, primarily through the induction of cytokine and cytokine receptors. Several transcription factor families, including NF-κB/Rel, have been implicated in the regulation of cytokine gene expression in T cells in response to antigen, cytokine and mitogenic stimulation. In this study, we show that the mice with a null mutation in the lymphoid-specific c-Rel gene have normal development of lymphoid tissues and T cell compartment. However, T cells derived from the c-Rel knockout mice have several functional abnormalities. The c-Rel-deficient T lymphocytes fail to respond to activation and proliferation signals mediated by the TCR and mitogens in vitro. This is attributed to an impaired production of cytokines IL-2, IL-3 and granulocyte macrophage colony stimulating factor. In addition, the induction of IL-2Rα chain is impaired in the c-Rel–/– T cells. The poor expression of cytokines and IL-2Rα chain correlates with a reduced nuclear translocation of NF-κB components in c-Rel–/– T cells. Since activation is prerequisite for differentiation into effector cells, c-Rel–/– T cells failed to differentiate into cytotoxic T cells or Th cells without rescuing cytokines. However, upon supplement with exogenous IL-2, the c-Rel–/– cytotoxic T lymphocytes are able to execute cytotoxicity and the c-Rel–/– Th cells are capable of providing help to normal B cells. These data suggest that c-Rel is important for inducible cytokine and cytokine receptor expression, and a key regulator of early activation and proliferation in T cells." @default.
• W2166475162 created "2016-06-24" @default.
• W2166475162 creator A5014929190 @default.
• W2166475162 creator A5019024121 @default.
• W2166475162 creator A5021456348 @default.
• W2166475162 creator A5022871812 @default.
• W2166475162 creator A5035122235 @default.
• W2166475162 creator A5056703988 @default.
• W2166475162 date "1999-03-01" @default.
• W2166475162 modified "2023-09-23" @default.
• W2166475162 title "c-Rel is crucial for lymphocyte proliferation but dispensable for T cell effector function" @default.
• W2166475162 cites W1522773084 @default.
• W2166475162 cites W1534992089 @default.
• W2166475162 cites W1588586944 @default.
• W2166475162 cites W1594211558 @default.
• W2166475162 cites W1670243206 @default.
• W2166475162 cites W1717444875 @default.
• W2166475162 cites W1836845228 @default.
• W2166475162 cites W1967173876 @default.
• W2166475162 cites W1982062664 @default.
• W2166475162 cites W1982932518 @default.
• W2166475162 cites W1987676683 @default.
• W2166475162 cites W1987784311 @default.
• W2166475162 cites W1994688157 @default.
• W2166475162 cites W1994894837 @default.
• W2166475162 cites W2005484362 @default.
• W2166475162 cites W2008608024 @default.
• W2166475162 cites W2010428440 @default.
• W2166475162 cites W2012116939 @default.
• W2166475162 cites W2016642606 @default.
• W2166475162 cites W2017922713 @default.
• W2166475162 cites W2018718597 @default.
• W2166475162 cites W2023999210 @default.
• W2166475162 cites W2027569621 @default.
• W2166475162 cites W2028411896 @default.
• W2166475162 cites W2033810895 @default.
• W2166475162 cites W2035616122 @default.
• W2166475162 cites W2039766781 @default.
• W2166475162 cites W2040470926 @default.
• W2166475162 cites W2046241907 @default.
• W2166475162 cites W2049020751 @default.
• W2166475162 cites W2049671131 @default.
• W2166475162 cites W2059847344 @default.
• W2166475162 cites W2061903251 @default.
• W2166475162 cites W2068324509 @default.
• W2166475162 cites W2068433022 @default.
• W2166475162 cites W2073993982 @default.
• W2166475162 cites W2079135245 @default.
• W2166475162 cites W2088094960 @default.
• W2166475162 cites W2096589599 @default.
• W2166475162 cites W2097513054 @default.
• W2166475162 cites W2103944436 @default.
• W2166475162 cites W2116967057 @default.
• W2166475162 cites W2119490532 @default.
• W2166475162 cites W2122559781 @default.
• W2166475162 cites W2128725097 @default.
• W2166475162 cites W2140066663 @default.
• W2166475162 cites W2147507133 @default.
• W2166475162 cites W2155138543 @default.
• W2166475162 cites W2168889062 @default.
• W2166475162 cites W2288994304 @default.
• W2166475162 cites W2975506368 @default.
• W2166475162 cites W4237429324 @default.
• W2166475162 cites W4249497657 @default.
• W2166475162 doi "https://doi.org/10.1093/intimm/11.3.361" @default.
• W2166475162 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10221648" @default.
• W2166475162 hasPublicationYear "1999" @default.
• W2166475162 type Work @default.
• W2166475162 sameAs 2166475162 @default.
• W2166475162 citedByCount "165" @default.
• W2166475162 countsByYear W21664751622012 @default.
• W2166475162 countsByYear W21664751622013 @default.
• W2166475162 countsByYear W21664751622014 @default.
• W2166475162 countsByYear W21664751622015 @default.
• W2166475162 countsByYear W21664751622016 @default.
• W2166475162 countsByYear W21664751622017 @default.
• W2166475162 countsByYear W21664751622018 @default.
• W2166475162 countsByYear W21664751622019 @default.
• W2166475162 countsByYear W21664751622020 @default.
• W2166475162 countsByYear W21664751622021 @default.
• W2166475162 countsByYear W21664751622022 @default.
• W2166475162 crossrefType "journal-article" @default.
• W2166475162 hasAuthorship W2166475162A5014929190 @default.
• W2166475162 hasAuthorship W2166475162A5019024121 @default.
• W2166475162 hasAuthorship W2166475162A5021456348 @default.
• W2166475162 hasAuthorship W2166475162A5022871812 @default.
• W2166475162 hasAuthorship W2166475162A5035122235 @default.
• W2166475162 hasAuthorship W2166475162A5056703988 @default.
• W2166475162 hasBestOaLocation W21664751621 @default.
• W2166475162 hasConcept C120642132 @default.
• W2166475162 hasConcept C129374314 @default.
• W2166475162 hasConcept C153911025 @default.
• W2166475162 hasConcept C154317977 @default.
• W2166475162 hasConcept C202751555 @default.
• W2166475162 hasConcept C203014093 @default.
• W2166475162 hasConcept C2776090121 @default.
• W2166475162 hasConcept C2778690821 @default.
• W2166475162 hasConcept C55493867 @default.

• next