FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2166511050> ?p ?o ?g. }

• W2166511050 endingPage "2507" @default.
• W2166511050 startingPage "2491" @default.
• W2166511050 abstract "Histones found within transcriptionally competent and active regions of the genome are highly acetylated. Moreover, these highly acetylated histones have very short half-lives. Thus, both histone acetyltransferases and histone deacetylases must enrich within or near these euchromatic regions of the interphase chromatids. Using an antibody specific for highly acetylated histone H3, we have investigated the organization of transcriptionally active and competent chromatin as well as nuclear histone acetyltransferase and deacetylase activities. We observe an exclusion of highly acetylated chromatin around the periphery of the nucleus and an enrichment near interchromatin granule clusters (IGCs). The highly acetylated chromatin is found in foci that may reflect the organization of highly acetylated chromatin into “chromonema” fibers. Transmission electron microscopy of Indian muntjac fibroblast cell nuclei indicates that the chromatin associated with the periphery of IGCs remains relatively condensed, most commonly found in domains containing chromatin folded beyond 30 nm. Using electron spectroscopic imaging, we demonstrate that IGCs are clusters of ribonucleoprotein particles. The individual granules comprise RNA-rich fibrils or globular regions that fold into individual granules. Quantitative analysis of individual granules indicates that they contain variable amounts of RNA estimated between 1.5 and >10 kb. We propose that interchromatin granules are heterogeneous nuclear RNA-containing particles, some of which may be pre-mRNA generated by nearby transcribed chromatin. An intermediary zone between the IGC and surrounding chromatin is described that contains factors with the potential to provide specificity to the localization of sequences near IGCs." @default.
• W2166511050 created "2016-06-24" @default.
• W2166511050 creator A5022101184 @default.
• W2166511050 creator A5061205525 @default.
• W2166511050 creator A5073472372 @default.
• W2166511050 date "1998-09-01" @default.
• W2166511050 modified "2023-09-28" @default.
• W2166511050 title "Organization of Highly Acetylated Chromatin around Sites of Heterogeneous Nuclear RNA Accumulation" @default.
• W2166511050 cites W1497153204 @default.
• W2166511050 cites W1499490171 @default.
• W2166511050 cites W1511138521 @default.
• W2166511050 cites W1549536215 @default.
• W2166511050 cites W1589190814 @default.
• W2166511050 cites W1919634504 @default.
• W2166511050 cites W1941419571 @default.
• W2166511050 cites W1963539429 @default.
• W2166511050 cites W1966414797 @default.
• W2166511050 cites W1972908085 @default.
• W2166511050 cites W1981176424 @default.
• W2166511050 cites W1982225512 @default.
• W2166511050 cites W1983649021 @default.
• W2166511050 cites W1984655439 @default.
• W2166511050 cites W1985460850 @default.
• W2166511050 cites W1992108755 @default.
• W2166511050 cites W1996504826 @default.
• W2166511050 cites W1998475589 @default.
• W2166511050 cites W1999284679 @default.
• W2166511050 cites W2004608686 @default.
• W2166511050 cites W2013050831 @default.
• W2166511050 cites W2014672146 @default.
• W2166511050 cites W2017183849 @default.
• W2166511050 cites W2021136215 @default.
• W2166511050 cites W2022395114 @default.
• W2166511050 cites W2024993060 @default.
• W2166511050 cites W2032008430 @default.
• W2166511050 cites W2032391484 @default.
• W2166511050 cites W2034207297 @default.
• W2166511050 cites W2039159642 @default.
• W2166511050 cites W2044236601 @default.
• W2166511050 cites W2045251725 @default.
• W2166511050 cites W2047666280 @default.
• W2166511050 cites W2051525713 @default.
• W2166511050 cites W2055214710 @default.
• W2166511050 cites W2056216005 @default.
• W2166511050 cites W2060496666 @default.
• W2166511050 cites W2071142061 @default.
• W2166511050 cites W2075521423 @default.
• W2166511050 cites W2080309374 @default.
• W2166511050 cites W2083831827 @default.
• W2166511050 cites W2086778920 @default.
• W2166511050 cites W2091955128 @default.
• W2166511050 cites W2092483878 @default.
• W2166511050 cites W2093646238 @default.
• W2166511050 cites W2094733358 @default.
• W2166511050 cites W2100539745 @default.
• W2166511050 cites W2107959123 @default.
• W2166511050 cites W2112514675 @default.
• W2166511050 cites W2116359481 @default.
• W2166511050 cites W2135271276 @default.
• W2166511050 cites W2137595520 @default.
• W2166511050 cites W2139440539 @default.
• W2166511050 cites W2140208392 @default.
• W2166511050 cites W2140576339 @default.
• W2166511050 cites W2142325700 @default.
• W2166511050 cites W2146589802 @default.
• W2166511050 cites W2151199680 @default.
• W2166511050 cites W2155512899 @default.
• W2166511050 cites W2156511074 @default.
• W2166511050 cites W2158363060 @default.
• W2166511050 cites W2244187993 @default.
• W2166511050 cites W2258126634 @default.
• W2166511050 cites W4285719527 @default.
• W2166511050 cites W4323526268 @default.
• W2166511050 doi "https://doi.org/10.1091/mbc.9.9.2491" @default.
• W2166511050 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/25517" @default.
• W2166511050 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9725908" @default.
• W2166511050 hasPublicationYear "1998" @default.
• W2166511050 type Work @default.
• W2166511050 sameAs 2166511050 @default.
• W2166511050 citedByCount "90" @default.
• W2166511050 countsByYear W21665110502012 @default.
• W2166511050 countsByYear W21665110502013 @default.
• W2166511050 countsByYear W21665110502016 @default.
• W2166511050 countsByYear W21665110502017 @default.
• W2166511050 countsByYear W21665110502018 @default.
• W2166511050 countsByYear W21665110502019 @default.
• W2166511050 countsByYear W21665110502021 @default.
• W2166511050 crossrefType "journal-article" @default.
• W2166511050 hasAuthorship W2166511050A5022101184 @default.
• W2166511050 hasAuthorship W2166511050A5061205525 @default.
• W2166511050 hasAuthorship W2166511050A5073472372 @default.
• W2166511050 hasBestOaLocation W21665110502 @default.
• W2166511050 hasConcept C100924687 @default.
• W2166511050 hasConcept C101152365 @default.
• W2166511050 hasConcept C103435993 @default.
• W2166511050 hasConcept C104317684 @default.
• W2166511050 hasConcept C119157956 @default.
• W2166511050 hasConcept C153911025 @default.

• next