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• W2166522903 abstract "Newcastle disease virus (NDV) is an avian paramyxovirus that exists as hundreds of strains with widely different virulence properties. The NDV V protein exhibits interferon (IFN) antagonistic activity, which contributes to the virulence of the virus. The IFN-antagonistic activities of the V proteins from the avirulent strain La Sota and the moderately virulent strain Beaudette C (BC) were compared in an assay for the rescue of a recombinant NDV expressing the green fluorescent protein (NDV-GFP). Consistent with the virulence properties of the two viruses, the BC V protein exhibits a 4-fold greater ability to rescue replication of NDV-GFP than the La Sota V protein. Four amino acid differences in the C-terminal region of V, as well as the N-terminal region, contribute to the difference in IFN-antagonistic activity between the two V proteins." @default.
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• W2166522903 date "2010-01-01" @default.
• W2166522903 modified "2023-09-30" @default.
• W2166522903 title "The interferon antagonistic activities of the V proteins from two strains of Newcastle disease virus correlate with their known virulence properties" @default.
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• W2166522903 doi "https://doi.org/10.1016/j.virusres.2009.10.020" @default.
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