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• W2166525781 abstract "There is a need to develop methods to automatically incorporate prior knowledge to support the prediction and validation of novel functional associations. One such important source is represented by the (GO)trade and the many model organism databases of gene products annotated to the GO. We investigated quantitative relationships between the GO-driven similarity of genes and their functional interactions by analyzing different types of associations in Saccharomyces cerevisiae and Caenorhabditis elegans. Interacting genes exhibited significantly higher levels of GO-driven similarity (GOS) in comparison to random pairs of genes used as a surrogate for negative interactions. The biological process hierarchy provides more reliable results for co-regulatory and protein-protein interactions. GOS represent a relevant resource to support prediction of functional networks in combination with other resources" @default.
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• W2166525781 date "2006-12-01" @default.
• W2166525781 modified "2023-10-16" @default.
• W2166525781 title "Predictive Integration of Gene Ontology-Driven Similarity and Functional Interactions" @default.
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• W2166525781 doi "https://doi.org/10.1109/icdmw.2006.130" @default.
• W2166525781 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4331034" @default.
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