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• W2166543157 abstract "<h3>Objective</h3> To compare survival and to identify prognostic predictors for progressive supranuclear palsy and frontotemporal dementia. <h3>Background</h3> Progressive supranuclear palsy (PSP) and frontotemporal dementia (FTD) are related disorders. Homozygosity for H1 haplotype is associated with PSP, whereas several <i>MAPT</i> mutations have been identified in FTLD-τ. Survival duration probably reflects underlying pathophysiology or disease. <h3>Methods</h3> Patients with PSP and FTD were recruited by nationwide referral. Survival of 354 FTD patients was compared with that of 197 PSP patients. Cox regression analysis was performed to identify prognostic predictors. FTLD-τ was defined as Pick disease and FTDP-17 with <i>MAPT</i> mutations. Semiquantitative evaluation of τ-positive pathology was performed on all pathologically proven cases. <h3>Results</h3> The median survival of PSP patients (8.0 years; 95% CI 7.3 to 8.7) was significantly shorter than that of FTD patients (9.9 years; 95% CI 9.2 to 10.6). Corrected for demographic differences, PSP patients were still significantly more at risk of dying than FTD patients. In PSP, male gender, older onset-age and higher PSP Rating Scale score were identified as independent predictors for shorter survival, whereas in FTD a positive family history and an older onset-age were associated with a poor prognosis. The difference in hazard rate was even more pronounced when comparing pathologically proven cases of PSP with FTLD-τ. <h3>Conclusion</h3> Survival of PSP patients is shorter than that of FTD patients, and probably reflects a more aggressive disease process in PSP. Independent predictors of shorter survival in PSP were male gender, older onset-age and higher PSP rating scale score, whereas in FTD a positive family history and higher onset-age were predictors for worse prognosis." @default.
• W2166543157 created "2016-06-24" @default.
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• W2166543157 date "2010-04-01" @default.
• W2166543157 modified "2023-10-13" @default.
• W2166543157 title "Survival in progressive supranuclear palsy and frontotemporal dementia" @default.
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• W2166543157 doi "https://doi.org/10.1136/jnnp.2009.195719" @default.
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