Matches in SemOpenAlex for { <https://semopenalex.org/work/W2166598738> ?p ?o ?g. }
- W2166598738 endingPage "1032" @default.
- W2166598738 startingPage "1021" @default.
- W2166598738 abstract "In healthy cells, Bax resides inactive in the cytosol because its COOH-terminal transmembrane region (TMB) is tucked into a hydrophobic pocket. During apoptosis, Bax undergoes a conformational change involving NH2-terminal exposure and translocates to mitochondria to release apoptogenic factors. How this process is regulated remains unknown. We show that the TMB of Bax is both necessary and sufficient for mitochondrial targeting. However, its availability for targeting depends on Pro168 located within the preceding loop region. Pro168 mutants of Bax lack apoptotic activity, cannot rescue the apoptosis-resistant phenotype of Bax/Bak double knockout cells, and are retained in the cytosol even in response to apoptotic stimuli. Moreover, the mutants have their NH2 termini exposed. We propose that Pro168 links the NH2 and the COOH terminus of Bax and is required for COOH-terminal release and mitochondrial targeting once this link is broken." @default.
- W2166598738 created "2016-06-24" @default.
- W2166598738 creator A5036507802 @default.
- W2166598738 creator A5046291484 @default.
- W2166598738 creator A5080355773 @default.
- W2166598738 creator A5082560419 @default.
- W2166598738 creator A5088962570 @default.
- W2166598738 creator A5090130012 @default.
- W2166598738 date "2004-03-22" @default.
- W2166598738 modified "2023-10-14" @default.
- W2166598738 title "Conformational control of Bax localization and apoptotic activity by Pro168" @default.
- W2166598738 cites W1534241867 @default.
- W2166598738 cites W1598794829 @default.
- W2166598738 cites W1644953918 @default.
- W2166598738 cites W1835922068 @default.
- W2166598738 cites W1880554341 @default.
- W2166598738 cites W1965217295 @default.
- W2166598738 cites W1966081420 @default.
- W2166598738 cites W1969439607 @default.
- W2166598738 cites W1972279573 @default.
- W2166598738 cites W1975753425 @default.
- W2166598738 cites W1976720365 @default.
- W2166598738 cites W1976883744 @default.
- W2166598738 cites W1981810393 @default.
- W2166598738 cites W1984547206 @default.
- W2166598738 cites W1989223012 @default.
- W2166598738 cites W1994611236 @default.
- W2166598738 cites W1995150044 @default.
- W2166598738 cites W1996952569 @default.
- W2166598738 cites W2000093730 @default.
- W2166598738 cites W2000529918 @default.
- W2166598738 cites W2003380824 @default.
- W2166598738 cites W2012974735 @default.
- W2166598738 cites W2013319326 @default.
- W2166598738 cites W2014586657 @default.
- W2166598738 cites W2017671645 @default.
- W2166598738 cites W2026873116 @default.
- W2166598738 cites W2032049833 @default.
- W2166598738 cites W2051575178 @default.
- W2166598738 cites W2052793452 @default.
- W2166598738 cites W2054820743 @default.
- W2166598738 cites W2060184827 @default.
- W2166598738 cites W2060809301 @default.
- W2166598738 cites W2064011682 @default.
- W2166598738 cites W2073028327 @default.
- W2166598738 cites W2088582692 @default.
- W2166598738 cites W2088805436 @default.
- W2166598738 cites W2090137644 @default.
- W2166598738 cites W2092108176 @default.
- W2166598738 cites W2095122505 @default.
- W2166598738 cites W2107434475 @default.
- W2166598738 cites W2108972313 @default.
- W2166598738 cites W2114001234 @default.
- W2166598738 cites W2128347259 @default.
- W2166598738 cites W2134872883 @default.
- W2166598738 cites W2136269288 @default.
- W2166598738 cites W2140967934 @default.
- W2166598738 cites W2143067729 @default.
- W2166598738 cites W2143755436 @default.
- W2166598738 cites W2152247516 @default.
- W2166598738 cites W2162944051 @default.
- W2166598738 cites W2165546509 @default.
- W2166598738 cites W2171365668 @default.
- W2166598738 cites W2329004735 @default.
- W2166598738 cites W80462140 @default.
- W2166598738 doi "https://doi.org/10.1083/jcb.200309013" @default.
- W2166598738 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2172067" @default.
- W2166598738 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15037603" @default.
- W2166598738 hasPublicationYear "2004" @default.
- W2166598738 type Work @default.
- W2166598738 sameAs 2166598738 @default.
- W2166598738 citedByCount "132" @default.
- W2166598738 countsByYear W21665987382012 @default.
- W2166598738 countsByYear W21665987382013 @default.
- W2166598738 countsByYear W21665987382014 @default.
- W2166598738 countsByYear W21665987382015 @default.
- W2166598738 countsByYear W21665987382016 @default.
- W2166598738 countsByYear W21665987382017 @default.
- W2166598738 countsByYear W21665987382018 @default.
- W2166598738 countsByYear W21665987382019 @default.
- W2166598738 countsByYear W21665987382020 @default.
- W2166598738 countsByYear W21665987382021 @default.
- W2166598738 countsByYear W21665987382022 @default.
- W2166598738 countsByYear W21665987382023 @default.
- W2166598738 crossrefType "journal-article" @default.
- W2166598738 hasAuthorship W2166598738A5036507802 @default.
- W2166598738 hasAuthorship W2166598738A5046291484 @default.
- W2166598738 hasAuthorship W2166598738A5080355773 @default.
- W2166598738 hasAuthorship W2166598738A5082560419 @default.
- W2166598738 hasAuthorship W2166598738A5088962570 @default.
- W2166598738 hasAuthorship W2166598738A5090130012 @default.
- W2166598738 hasBestOaLocation W21665987381 @default.
- W2166598738 hasConcept C104317684 @default.
- W2166598738 hasConcept C12519072 @default.
- W2166598738 hasConcept C143065580 @default.
- W2166598738 hasConcept C170493617 @default.
- W2166598738 hasConcept C173358068 @default.
- W2166598738 hasConcept C181199279 @default.