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- W2166600234 abstract "In severe, neutrophilic asthma, neutrophils are thought to have an important role in both the maintenance of the disease and during exacerbations. These patients often display excessive, mucosal airway inflammation with unresolving neutrophilia. Because this variant of asthma is poorly controlled by glucocorticoids, specific pharmacologic targeting of neutrophils seems a plausible therapeutic approach. However, most attempts with this approach have failed in the clinic. We propose that this could be attributed, in part, to an incomplete understanding of the emerging new insights underlying neutrophil homeostasis and life span, neutrophil reverse transmigration, neutrophil phenotypes, and neutrophil transdifferentiation in human health and disease. Of clinical relevance, recent translational studies have started to uncover distinct neutrophil subsets in humans, namely mature and hypersegmented phenotypes that have bimodal immunomodulatory functions during an acute inflammatory response. In this review, we will elaborate on some of the novel insights in neutrophil biology and attempt to translate them into potential consequences for pharmacologic intervention of severe neutrophilic asthma. We speculate that the disease-relevant neutrophil phenotype should be targeted selectively without compromising the immunomodulatory functions essential for homeostasis and pulmonary immunity. However, the identity and exact functional role of distinct neutrophil phenotypes in inflammatory diseases of the human airway remain elusive." @default.
- W2166600234 created "2016-06-24" @default.
- W2166600234 creator A5031159404 @default.
- W2166600234 creator A5053798294 @default.
- W2166600234 creator A5069889145 @default.
- W2166600234 date "2015-05-14" @default.
- W2166600234 modified "2023-10-14" @default.
- W2166600234 title "Targeting neutrophilic inflammation in severe neutrophilic asthma: can we target the disease-relevant neutrophil phenotype?" @default.
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- W2166600234 doi "https://doi.org/10.1189/jlb.3vmr1214-600rr" @default.
- W2166600234 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25977288" @default.